DA-JC1 improves learning and memory by antagonizing Aβ31–35-induced circadian rhythm disorder

Xanthoceraside attenuates amyloid β peptide 1-42 -induced memory impairments by reducing neuroinflammatory responses in mice

(2018) Yue Qi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

D-Ala2GIP Facilitated Synaptic Plasticity and Reduces Plaque Load in Aged Wild Type Mice and in an Alzheimer's Disease Mouse Model

(2018) Emilie Faivre et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

(2018) Janine L. Kwapis et al.   Nature Communications

Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury

(2017) Ian A. Tamargo et al.   EXPERIMENTAL NEUROLOGY

miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice

(2017) Xiaoxue Du et al.   TOXICOLOGY LETTERS

Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice

(2017) Bo Wang et al.   BMC Anesthesiology

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

(2017) Chiara La Morgia et al.   Frontiers in Neurology

Alterations in the expression of Per1 and Per2 induced by Aβ31-35 in the suprachiasmatic nucleus, hippocampus, and heart of C57BL/6 mouse

(2016) Xiaohui Wang et al.   BRAIN RESEARCH

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

(2016) Chenhui Ji et al.   BRAIN RESEARCH

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

(2016) Lijun Cao et al.   NEUROREPORT

A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

(2016) Ling Han et al.   NEUROREPORT

Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

(2016) Yanwei Li et al.   REVIEWS IN THE NEUROSCIENCES

Liraglutide Activates AMPK Signaling and Partially Restores Normal Circadian Rhythm and Insulin Secretion in Pancreatic Islets in Diabetic Mice

(2015) Kexin Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice

(2015) Daisuke Ono et al.   Scientific Reports

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

A time to remember: The role of circadian clocks in learning and memory.

(2014) Benjamin L. Smarr et al.   BEHAVIORAL NEUROSCIENCE

PERIOD1 coordinates hippocampal rhythms and memory processing with daytime

(2014) Oliver Rawashdeh et al.   HIPPOCAMPUS

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor Necrosis Factor and Transforming Growth Factor β Regulate Clock Genes by Controlling the Expression of the Cold Inducible RNA-binding Protein (CIRBP)

(2013) Martin Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

(2013) Holly J. Garringer et al.   PLoS One

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease

(2012) Marilyn J. Duncan et al.   EXPERIMENTAL NEUROLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

(2012) A.M. Duffy et al.   NEUROSCIENCE

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

(2011) Subbiah Pugazhenthi et al.   Molecular Neurodegeneration

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

(2010) Michael E. Hughes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Effects of a constant light environment on hippocampal neurogenesis and memory in mice

(2010) Aya Fujioka et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

(2009) Louisa M-C Wang et al.   ASN Neuro