Article
Neurosciences
Amrita Benoy, Mohammad Zaki Bin Ibrahim, Thomas Behnisch, Sreedharan Sajikumar
Summary: Research shows that activation of cholinergic receptors in the hippocampal CA2 area regulates synaptic plasticity, with muscarinic acetylcholine receptors playing a role in early facilitation and nicotinic acetylcholine receptors involved in late maintenance. Furthermore, priming with cholinergic stimulation lowers the threshold for subsequent long-term potentiation induction and demonstrates a metaplastic regulation of CA2 synaptic learning rules.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jeffrey Lopez-Rojas, Christopher A. de Solis, Felix Leroy, Eric R. Kandel, Steven A. Siegelbaum
Summary: The dorsal CA2 region of the hippocampus is crucial for social memory, and it receives direct inputs from the medial and lateral subdivisions of entorhinal cortex, with the latter being selectively activated during social exploration and required for social memory.
Article
Neurosciences
Mahsa Samadi, Claire A. Hales, Daniel J. Lustberg, Shannon Farris, Madeleine R. Ross, Meilan Zhao, John R. Hepler, Nicholas H. Harbin, Emma S. J. Robinson, Paul J. Banks, Zafar I. Bashir, Serena M. Dudek
Summary: Pyramidal cells in hippocampal area CA2 have distinct synaptic properties, including a lack of typical long-term potentiation. This study investigated the role of metabotropic glutamate receptor (mGluR)-dependent signaling regulators in CA2 synaptic plasticity. The results showed that mGluR agonist-induced long-term depression (mGluR-LTD) is more pronounced in CA2 compared to CA1, and that this process depends on protein synthesis and the presence of STEP and RGS14 proteins. Additionally, RGS14 was found to play a crucial role in CA2 mGluR-LTD. Furthermore, RGS14 knockout mice showed impaired social recognition memory, suggesting a role for CA2 synaptic plasticity in social cognition.
Review
Neurosciences
Rebecca A. Piskorowski, Vivien Chevaleyre
Summary: The hippocampal area CA2 plays a crucial role in social recognition memory and has unique cellular and molecular properties. It has a high density of interneurons and displays two distinct forms of long-term synaptic plasticity. Recent studies have revealed changes in inhibitory transmission and plasticity of CA2 in mouse models of neurological disorders such as multiple sclerosis, autism spectrum disorder, Alzheimer's disease, schizophrenia, and the 22q11.2 deletion syndrome. These findings suggest that these changes in CA2 could contribute to the social cognitive deficits observed in these disorders.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Anatomy & Morphology
Yuki Takeuchi, Kotaro Yamashiro, Asako Noguchi, Jiayan Liu, Shinichi Mitsui, Yuji Ikegaya, Nobuyoshi Matsumoto
Summary: The hippocampus is a key area for learning, memory, and spatial navigation. The CA2 region is particularly important for social behavior. Manual segmentation methods are impractical and dependent on experimenters' proficiency, so we developed CAseg, an automated algorithm based on machine learning, to accurately segment the CA2 area from microscopic images. This algorithm will be valuable for investigating the unique properties of the hippocampal CA2 area.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Biochemistry & Molecular Biology
Liliya Kushnireva, Kanishka Basnayake, David Holcman, Menahem Segal, Eduard Korkotian
Summary: This study investigates the effects of cytosolic calcium surges on mitochondrial calcium concentration in cultured rat hippocampal neurons. It identifies local and global calcium events, and suggests that the cytosolic and mitochondrial calcium concentrations are highly correlated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Leila Etemadi, Jonas M. D. Enander, Henrik Jorntell
Summary: Brief electrical stimulation of the hippocampus can alter the cortical response to tactile inputs. The output from the hippocampus has a significant impact on the response types displayed by somatosensory cortex neurons.
Article
Neurosciences
Daniel Radzicki, Sarah Chong, Serena M. Dudek
Summary: Hippocampal area CA2 is a distinct region of the hippocampus that can be defined by molecular markers. Some commonly used markers are better suited for defining the border between CA2/3 and CA2/1. In addition, there are fewer complex spines in CA2 compared to CA3.
Article
Neurosciences
Anita Lewczuk, Barbara Zablocka, Malgorzata Beresewicz-Haller
Summary: The transcription factor Nrf2 plays a crucial role in regulating genes involved in antioxidant and anti-inflammatory processes, metabolic regulation, and other cellular functions. This study investigates the activation of Nrf2 in different regions of the hippocampus and its impact on endogenous neuroprotection against ischemia-reperfusion (I/R) injury. The results reveal that CA2-4,DG in the hippocampus exhibits higher Nrf2 activity compared to CA1, indicating a potential mechanism explaining the different sensitivities of these regions to I/R injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Hongshen He, Roman Boehringer, Arthur J. Y. Huang, Eric T. N. Overton, Denis Polygalov, Kazuo Okanoya, Thomas J. McHugh
Summary: Research suggests that CA2 activity plays a crucial role in the fidelity of experience-dependent hippocampal replay. By temporarily silencing CA2 pyramidal cells, it was observed that the reactivation of CA1 pyramidal cell ensembles within sharp-wave ripples events lost both temporal and informational precision.
Article
Neurosciences
Azahara Oliva, Antonio Fernandez-Ruiz, Lindsay A. Karaba
Summary: The hippocampus is composed of different subregions, and CA2 has recently gained attention for its unique properties and functional roles. Recent studies utilizing new genetic and physiological tools have revealed the involvement of CA2 in social behaviors and memory. Evidence suggests that CA2 plays a role in coordinating hippocampal network dynamics.
Article
Neurosciences
Maithe Loisy, Amel Farah, Assia Fafouri, Aurelien Fanton, Mahboubeh Ahmadi, Ludivine Therreau, Vivien Chevaleyre, Rebecca A. Piskorowski
Summary: This study aimed to investigate the impact of environmental conditions on synaptic plasticity in the hippocampal area CA2. The research found that inhibitory transmission in the CA2 region of mice housed in an enriched environment was less plastic compared to mice housed in a standard environment. The study also showed that delta-opioid receptor-mediated plasticity was reduced in enriched environment conditions, and overall levels of GABA transmission were decreased. Additionally, the effect of the environment on synaptic plasticity could be rapidly reversed by social isolation.
Article
Pharmacology & Pharmacy
Zi-Fan Mai, Zhi-Ping Cao, Shu-Yi Huang, Wen-Wen Yan, Jun-Ni Huang, Bao-Yan Wu, Chu-Hua Li
Summary: Cordycepin may modulate metaplasticity in the hippocampal CA1 area of rats through adenosine A(1) receptors, affecting the induction of LTP and LTD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Sami I. Hassan, Shivani Bigler, Steven A. Siegelbaum
Summary: This study investigated the mechanisms for social sensory information processing in the hippocampus using two-photon calcium imaging. The findings showed that CA2 pyramidal neurons represent social odors of individual conspecifics and that these representations are refined during associative social odor-reward learning.
Article
Biochemistry & Molecular Biology
Zizhen Yao, Cindy T. J. van Velthoven, Thuc Nghi Nguyen, Jeff Goldy, Adriana E. Sedeno-Cortes, Fahimeh Baftizadeh, Darren Bertagnolli, Tamara Casper, Megan Chiang, Kirsten Crichton, Song-Lin Ding, Olivia Fong, Emma Garren, Alexandra Glandon, Nathan W. Gouwens, James Gray, Lucas T. Graybuck, Michael J. Hawrylycz, Daniel Hirschstein, Matthew Kroll, Kanan Lathia, Changkyu Lee, Boaz Levi, Delissa McMillen, Stephanie Mok, Thanh Pham, Qingzhong Ren, Christine Rimorin, Nadiya Shapovalova, Josef Sulc, Susan M. Sunkin, Michael Tieu, Amy Torkelson, Herman Tung, Katelyn Ward, Nick Dee, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng
Summary: This study provides a comprehensive analysis of cell types in the mammalian isocortex and hippocampal formation, revealing a shared neural circuit organization between the two structures. The research also uncovers large-scale variations in cell types along different dimensions within these brain regions.
Article
Biochemistry & Molecular Biology
Alberto Sanchez-Aguilera, Diek W. Wheeler, Teresa Jurado-Parras, Manuel Valero, Miriam S. Nokia, Elena Cid, Ivan Fernandez-Lamo, Nate Sutton, Daniel Garcia-Rincon, Liset M. de la Prida, Giorgio A. Ascoli
Summary: This study focuses on understanding the dynamics of different brain-wide subcircuits by linking basic behavioral traits to cell-type specific dynamics. By mining literature and adding new data, the researchers explore the equivalences and differences across conditions, and offer novel observations. They also discuss the potential for classifying extracellular recordings of single cells and integrating single-cell phenotypes with circuit function in the future.
Editorial Material
Biochemical Research Methods
Yajie Liang, Liset M. de la Prida
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Editorial Material
Neurosciences
Judith R. Homberg, Roger A. H. Adan, Natalia Alenina, Antonis Asiminas, Michael Bader, Tom Beckers, Denovan P. Begg, Arjan Blokland, Marilise E. Burger, Gertjan van Dijk, Ulrich L. M. Eisel, Ype Elgersma, Bernhard Englitz, Antonio Fernandez-Ruiz, Carlos P. Fitzsimons, Anne-Marie van Dam, Peter Gass, Joanes Grandjean, Robbert Havekes, Marloes J. A. G. Henckens, Christiane Herden, Roelof A. Hut, Wendy Jarrett, Kate Jeffrey, Daniela Jezova, Andries Kalsbeek, Maarten Kamermans, Martien J. Kas, Nael Nadif Kasri, Amanda J. Kiliaan, Sharon M. Kolk, Aniko Korosi, S. Mechiel Korte, Tamas Kozicz, Steven A. Kushner, Kirk Leech, Klaus-Peter Leech, Heidi Lesscher, Paul J. Lucassen, Anita Luthi, Liya Ma, Anne S. Mallien, Peter Meerlo, Jorge F. Mejias, Frank J. Meye, Anna S. Mitchell, Joram D. Mul, Umberto Olcese, Azahara Oliva Gonzalez, Jocelien D. A. Oliver, Massimo Pasqualetti, CyrielM. A. Pennartz, Piotr Popik, Jos Prickaerts, Liset M. de la Prida, Sidarta Ribeiro, Benn Roozendaal, Janine I. Rossato, Ali-Akbar Salari, Regien G. Schoemaker, August B. Smit, Tomonori Takeuchi, Rixt van der Veen, Marten P. Smidt, Vladyslav V. Vyazovskiy, Maximilian Wiesmann, Corette J. Wierenga, Bella Williams, Ingo Willuhn, Markus Woehr, Monique Wolvekamp, Eddy A. van der Zee, Lisa Genzel, Louk J. M. J. Vanderschuren
Summary: Policymakers are working towards promoting animal-free alternatives in scientific research and have implemented strict regulations for animal research. However, in the field of neuroscience research, it is argued that the use of animals should not be compromised until viable and translational alternatives are available and proven to be valuable.
Article
Cell Biology
Elena Cid, Angel Marquez-Galera, Manuel Valero, Beatriz Gal, Daniel C. Medeiros, Carmen M. Navarron, Luis Ballesteros-Esteban, Rita Reig-Viader, Aixa Morales, Ivan Fernandez-Lamo, Daniel Gomez-Dominguez, Masaaki Sato, Yasunori Hayashi, Alex Bayes, Angel Barco, Jose P. Lopez-Atalaya, Liset M. de la Prida
Summary: Hippocampal sclerosis, a major neuropathological feature of temporal lobe epilepsy, is characterized by overactive superficial CA1 pyramidal neurons in epileptic rodents. Single-cell gene expression analysis reveals sublayer-specific transcriptomic signatures and robust microglial pro-inflammatory responses. Neurodegenerative signatures primarily involve superficial cells.
Article
Cell Biology
Lingling Li, Cristina Medina-Menendez, Laura Garcia-Corzo, Carmen M. Cordoba-Beldad, Alejandra C. Quiroga, Elena Calleja Barca, Valeriya Zinchuk, Sara Munoz-Lopez, Pilar Rodriguez-Martin, Maria Ciorraga, Ines Colmena, Silvia Fernandez, Carlos Vicario, Silvia K. Nicolis, Veronique Lefebvre, Helena Mira, Aixa Morales
Summary: Research shows that SoxD transcription factors Sox5 and Sox6 are enriched in activated radial glia-like neural stem cells, and deletion of these genes in adult mouse brains affects RGL activation and generation of new neurons. Loss of Sox5 also hinders activation of RGLs driven by neurogenic stimuli.
Article
Materials Science, Multidisciplinary
Filippo Pisano, Muhammad Fayyaz Kashif, Antonio Balena, Marco Pisanello, Francesco De Angelis, Liset M. de la Prida, Manuel Valiente, Antonella D'Orazio, Massimo De Vittorio, Marco Grande, Ferruccio Pisanello
Summary: Optical methods are revolutionizing neuroscience by enabling control and monitoring of neural activity in deep brain regions. Researchers have proposed a nano-optical neural implant design utilizing plasmonic structures to enhance electric field enhancement, improve spectral and angular patterns of optical transmission, and facilitate multimodal neural applications. This represents a significant step towards versatile nano-optical neural implants for brain research in health and disease.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liam Collard, Filippo Pisano, Di Zheng, Antonio Balena, Muhammad Fayyaz Kashif, Marco Pisanello, Antonella D'Orazio, Liset M. de la Prida, Cristian Ciraci, Marco Grande, Massimo De Vittorio, Ferruccio Pisanello
Summary: This paper discusses the integration of plasmonic structures on optical fibers and its potential applications. The turbidity of light propagation in multimode fibers hinders dynamic control of the coupling between guided light fields and plasmonic resonances. Utilizing the information of guided modes, the authors demonstrate the spatiotemporal control of plasmonic resonances by employing dynamic phase modulation.
Article
Multidisciplinary Sciences
Alicia Hernandez-Vivanco, Nuria Cano-Adamuz, Alberto Sanchez-Aguilera, Alba Gonzalez-Alonso, Alberto Rodriguez-Fernandez, Inigo Azcoitia, Liset Menendez de la Prida, Pablo Mendez
Summary: Using a combination of molecular, genetic, functional and behavioural tools, this study describes the impact of brain synthesized estrogen on inhibitory neuronal function, network oscillations and hippocampal dependent memory.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Clinical Neurology
Candela Sanchez-Bellot, Liset Menendez de la Prida
Summary: Research found that temporal lobe epilepsy can lead to abnormal distribution of granule cells and changes in dendritic morphology. This may be related to impaired neuronal migration, changes in dendritic spine density.
Article
Cell Biology
Manuel Valero, Andrea Navas-Olive, Liset M. de la Prida, Gyorgy Buzsaki
Summary: This study investigates the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses and finds that inhibition is stronger than excitation and critical for place field expression.
Article
Biology
Andrea Navas-Olive, Rodrigo Amaducci, Maria-Teresa Jurado-Parras, Enrique R. Sebastian, Liset M. de la Prida
Summary: Local field potential (LFP) deflections and oscillations define hippocampal sharp-wave ripples (SWRs), one of the most synchronous events of the brain. Automatic identification of SWRs using one-dimensional convolutional networks allows for discovery of physiologically relevant processes associated to the emergence of SWR.
Review
Genetics & Heredity
Jair Tenorio-Castano, Angela Sanchez-Algaba Gomez, Monica Coronado, Pilar Rodriguez-Martin, Alejandro Parra, Patricia Pascual, Mario Cazalla, Natalia Gallego, Pedro Arias, Aixa V. Morales, Julian Nevado, Pablo Lapunzina
Summary: Lamb-Shaffer syndrome is a rare genetic disorder that primarily affects the development of the nervous system, causing symptoms such as intellectual disability, delayed speech development, and visual problems. The syndrome is caused by mutations in the SOX5 gene and early diagnosis is crucial for the well-being of patients and their families.
Article
Neurosciences
Julio Esparza, Enrique R. Sebastian, Liset M. de la Prida
Summary: The study of the hippocampal code is progressing, with a focus on both individual cells and population dynamics. By projecting neuronal activity into low-dimensional manifolds, the structure of population representations can be revealed, although their physiological interpretation remains challenging. Integrating information from behavioral traits, local field potential oscillations, and cell-type-specificity into neural manifolds may provide strategies for interpreting them at a physiological level.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Enrique R. Sebastian, Juan P. Quintanilla, Alberto Sanchez-Aguilera, Julio Esparza, Elena Cid, Liset M. de la Prida
Summary: In this study, the authors used topological and dimensionality reduction techniques to analyze the waveform of ripples recorded in the hippocampus. They found that the waveforms distribute in a low-dimensional space, conveying information about the underlying synaptic inputs. The study also revealed variations in ripple waveforms during wakefulness, sleep, and learning.
NATURE NEUROSCIENCE
(2023)