From Chemical Mutagenesis to Post-Expression Mutagenesis: A 50 Year Odyssey

Genetically Encoding Lysine Modifications on Histone H4

(2015) Bryan J. Wilkins et al.   ACS Chemical Biology

Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones

(2015) Han Xiao et al.   ACS Chemical Biology

Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine

(2015) Lara R. Malins et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic strategies and biocatalysts for amide bond formation: tricks of the trade outside of the ribosome

(2015) Anwesha Goswami et al.   Molecular BioSystems

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

(2015) Daniel T Rogerson et al.   Nature Chemical Biology

Designing logical codon reassignment – Expanding the chemistry in biology

(2015) Anaëlle Dumas et al.   Chemical Science

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

(2015) Lukas Lercher et al.   Nature Communications

Formylglycine, a Post-Translationally Generated Residue with Unique Catalytic Capabilities and Biotechnology Applications

(2014) Mason J. Appel et al.   ACS Chemical Biology

Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

(2014) K. Phin Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Revealing the amino acid composition of proteins within an expanded genetic code

(2014) Hans R. Aerni et al.   NUCLEIC ACIDS RESEARCH

Expressed Protein Ligation at Methionine: N-Terminal Attachment of Homocysteine, Ligation, and Masking

(2013) Tomohiro Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Facile Strategy for Selective Incorporation of Phosphoserine into Histones

(2013) Sangsik Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific and Regiospecific Installation of Methylarginine Analogues into Recombinant Histones and Insights into Effector Protein Binding

(2013) Daniel D. Le et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cross-Metathesis for Reversible Protein Modifications via Chemical Access to Se-Allyl-selenocysteine in Proteins

(2013) Yuya A. Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective sulfenylation and peptide ligation at tryptophan

(2013) Lara R. Malins et al.   Chemical Science

Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications

(2012) Justin M. Chalker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Incorporation of ε-N-Crotonyllysine into Histones

(2012) Chan Hyuk Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

Quantitative Assessment of Protein Interaction with Methyl-Lysine Analogues by Hybrid Computational and Experimental Approaches

(2011) Daniel Seeliger et al.   ACS Chemical Biology

A Direct Method for Site-Specific Protein Acetylation

(2011) Fupeng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation Combined with Desulfurization and Deselenization: A General Strategy for Chemical Protein Synthesis

(2011) Philip E. Dawson   ISRAEL JOURNAL OF CHEMISTRY

A Genetically Encoded ε-N-Methyl Lysine in Mammalian Cells

(2010) Dan Groff  et al.   CHEMBIOCHEM

A method to site-specifically introduce methyllysine into proteins in E. coli

(2010) Hui-wang Ai et al.   CHEMICAL COMMUNICATIONS

Genetically Directing ɛ-N, N-Dimethyl-l-Lysine in Recombinant Histones

(2010) Duy P. Nguyen et al.   CHEMISTRY & BIOLOGY

Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis

(2009) Nicola Floyd et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions

(2009) Guangshuai Jia et al.   CELL RESEARCH

Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

(2009) Justin M. Chalker et al.   Chemistry-An Asian Journal

Genetically EncodingNϵ-Methyl-l-lysine in Recombinant Histones

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Convenient Catalyst for Aqueous and Protein Suzuki−Miyaura Cross-Coupling

(2009) Justin M. Chalker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Genetically Encoded Boronate-Containing Amino Acid

(2008) Eric Brustad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoding Protein Oxidative Damage

(2008) Heinz Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allyl Sulfides Are Privileged Substrates in Aqueous Cross-Metathesis: Application to Site-Selective Protein Modification

(2008) Yuya A. Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

(2008) Gonçalo J. L. Bernardes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNACys

(2008) Chun-Mei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemical-modification rescue assessed by mass spectrometry demonstrates that γ-thia-lysine yields the same activity as lysine in aldolase

(2002) Christopher E. Hopkins et al.   PROTEIN SCIENCE