Transition-Metal-Free Regioselective Alkylation of Pyridine N -Oxides Using 1,1-Diborylalkanes as Alkylating Reagents

Catalytic SN 2′- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis

(2016) Ying Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Copper-Catalyzed SN2′-Selective Allylic Substitution Reaction of gem-Diborylalkanes

(2016) Zhen-Qi Zhang et al.   ORGANIC LETTERS

Copper-Catalyzed Diastereoselective Addition of Diborylmethane to N-tert-Butanesulfinyl Aldimines: Synthesis of β-Aminoboronates

(2016) Jinyoung Park et al.   ORGANIC LETTERS

Silver(I)-Catalyzed Diastereoselective Synthesis ofanti-1,2-Hydroxyboronates

(2015) Matthew V. Joannou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Branched Alkylboronates by Copper-Catalyzed Allylic Substitution Reactions of Allylic Chlorides with 1,1-Diborylalkanes

(2015) Junghoon Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction Optimization, Scalability, and Mechanistic Insight on the Catalytic Enantioselective Desymmetrization of 1,1-Diborylalkanes via Suzuki-Miyaura Cross-Coupling

(2015) Ho-Yan Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd(0)-Catalyzed Cross-Coupling of 1,1-Diboronates with 2,2′-Dibromobiphenyls: Synthesis of 9H-Fluorenes

(2015) Shuai Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantio- and Diastereoselective Synthesis of 1,2-Hydroxyboronates through Cu-Catalyzed Additions of Alkylboronates to Aldehydes

(2015) Matthew V. Joannou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alcohols as alkylating agents in heteroarene C–H functionalization

(2015) Jian Jin et al.   NATURE

Oxidative cross-coupling of pyridine N-oxides and ethers between C(sp2)–H/C(sp3)–H bonds under transition-metal-free conditions

(2015) Wei Sun et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines

(2015) Ying Chen et al.   ORGANIC LETTERS

Regioselective Metal-Free Cross-Coupling of Quinoline N-Oxides with Boronic Acids

(2015) Luis Bering et al.   ORGANIC LETTERS

Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

(2015) Takanori Shibata et al.   Organic Chemistry Frontiers

Palladium(0)-Catalyzed Cross-Coupling of 1,1-Diboronates with Vinyl Bromides and 1,1-Dibromoalkenes

(2014) Huan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

(2014) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct α-Arylation of Ethers through the Combination of Photoredox-Mediated CH Functionalization and the Minisci Reaction

(2014) Jian Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective C–H Bond Addition of Pyridines to Alkenes Catalyzed by Chiral Half-Sandwich Rare-Earth Complexes

(2014) Guoyong Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonracemic Allylic Boronates through Enantiotopic-Group-Selective Cross-Coupling of Geminal Bis(boronates) and Vinyl Halides

(2014) Bowman Potter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Catalytic Enantiotopic-Group-Selective Suzuki Reaction for the Construction of Chiral Organoboronates

(2014) Chunrui Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase

(2014) Jinghan Gui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple Access to Elusive α-Boryl Carbanions and Their Alkylation: An Umpolung Construction for Organic Synthesis

(2014) Kai Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis

(2014) John R. Coombs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides

(2014) David E. Stephens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed/Promoted Cross-coupling of gem-Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters

(2014) Zhen-Qi Zhang et al.   ORGANIC LETTERS

Direct, Catalytic, and Regioselective Synthesis of 2-Alkyl-, Aryl-, and Alkenyl-Substituted N-Heterocycles from N-Oxides

(2014) Oleg V. Larionov et al.   ORGANIC LETTERS

Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator

(2014) Tomoaki Nishida et al.   Nature Communications

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines

(2013) Takashi Andou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Selective Oxidative Cross-Coupling of Simple Alkanes with Heteroarenes

(2013) Andrey P. Antonchick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Direct Ortho-Alkylation of N-Iminopyridinium Ylides with N-Tosylhydrazones

(2013) Qing Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed C–H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides

(2013) Bin Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases

(2013) Kiyofumi Inamoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective Bromination of Fused Heterocyclic N-Oxides

(2013) Sarah E. Wengryniuk et al.   ORGANIC LETTERS

Iridium-catalyzed diborylation of benzylic C–H bonds directed by a hydrosilyl group: synthesis of 1,1-benzyldiboronate esters

(2013) Seung Hwan Cho et al.   Chemical Science

Recent Advances in Iridium-Catalyzed Alkylation of C–H and N–H Bonds

(2013) Shiguang Pan et al.   ACS Catalysis

Palladium-Catalyzed CH Oxidation of Isoquinoline N-Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides

(2012) Bo Yao et al.   ADVANCED SYNTHESIS & CATALYSIS

A Versatile Rhodium(I) Catalyst System for the Addition of Heteroarenes to both Alkenes and Alkynes by a CH Bond Activation

(2012) Jaeyune Ryu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines

(2012) James A. Bull et al.   CHEMICAL REVIEWS

Cross Coupling between sp3-Carbon and sp3-Carbon Using a Diborylmethane Derivative at Room Temperature

(2012) Kohei Endo et al.   JOURNAL OF ORGANIC CHEMISTRY

An Efficient, Regioselective Amination of 3,5-Disubstituted Pyridine N-Oxides Using Saccharin as an Ammonium Surrogate

(2012) Robert P. Farrell et al.   ORGANIC LETTERS

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rare-Earth-Catalyzed C–H Bond Addition of Pyridines to Olefins

(2011) Bing-Tao Guan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Suzuki Coupling of Diborylmethane for Facile Synthesis of Benzylboronates

(2011) Kohei Endo et al.   ORGANIC LETTERS

Facile One-Pot Direct Arylation and Alkylation of NitropyridineN-Oxides with Grignard Reagents

(2011) Fang Zhang et al.   ORGANIC LETTERS

Mild Addition of Nucleophiles to Pyridine-N-Oxides

(2011) Allyn T. Londregan et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed C-H Functionalization for the Synthesis of Substituted Pyridines

(2011) Yoshiaki Nakao   SYNTHESIS-STUTTGART

Efficient, mild and completely regioselective synthesis of substituted pyridines

(2010) Hans Andersson et al.   CHEMICAL COMMUNICATIONS

Chemoselective and Regiospecific Suzuki Coupling on a Multisubstituted sp3-Carbon in 1,1-Diborylalkanes at Room Temperature

(2010) Kohei Endo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective C-4 Alkylation of Pyridine by Nickel/Lewis Acid Catalysis

(2010) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct DehydrativeN-Pyridinylation of Amides

(2009) Jonathan William Medley et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation

(2008) Jared C. Lewis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Coupling of Nitrogen Heteroaromatics and Alkanes without Transition Metals: A New Oxidative Cross-Coupling at CH/CH Bonds

(2008) Guojun Deng et al.   CHEMISTRY-A EUROPEAN JOURNAL

One Step Conversion of Heteroaromatic-N-Oxides to Imidazolo-Heteroarenes

(2007) John M. Keith   JOURNAL OF ORGANIC CHEMISTRY