Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

An alternative approach to the synthesis of peptides containing a cystathionine bridge

(2016) Jitendra R. Harjani et al.   TETRAHEDRON

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

(2015) Mohammed Akhter Hossain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Replacement of the CysA7–CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine

(2015) Geoffrey M. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New forms of insulin and insulin therapies for the treatment of type 2 diabetes

(2015) Avivit Cahn et al.   Lancet Diabetes & Endocrinology

Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic

(2014) Alessandro Gori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diaminodiacid-Based Solid-Phase Synthesis of Peptide Disulfide Bond Mimics

(2013) Hong-Kui Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Critical Aspects to be Considered Prior to Large-Scale Production of Peptides

(2013) Kelly Mulder et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Replacement of Disulfides by Amide Bonds in the Relaxin-like Factor (RLF/INSL3) Reveals a Role for the A11–B10 Link in Transmembrane Signaling

(2012) Erika E. Büllesbach et al.   BIOCHEMISTRY

Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

(2012) Miriam Góngora-Benítez et al.   ORGANIC LETTERS

Insulin analog with additional disulfide bond has increased stability and preserved activity

(2012) Tine N. Vinther et al.   PROTEIN SCIENCE

“Triazole Bridge”: Disulfide-Bond Replacement by Ruthenium-Catalyzed Formation of 1,5-Disubstituted 1,2,3-Triazoles

(2011) Martin Empting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

(2011) Kai Holland-Nell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

(2011) Zoltan Dekan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

(2010) Suode Zhang et al.   PEPTIDES

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

(2009) Mohammed Akhter Hossain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design of an Active Ultrastable Single-chain Insulin Analog

(2008) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY