P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents

Rho-kinase Inhibitor Y-27632 Down-regulates LPS-induced IL-6 and IL-8 Production via Blocking p38 MAPK and NF-κB pathways in Human Gingival Fibroblasts

(2018) Wenyan Kang et al.   JOURNAL OF PERIODONTOLOGY

P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain

(2017) Mingjuan Liu et al.   Journal of Pain Research

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

(2016) G. O. Sipe et al.   Nature Communications

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain

(2014) Emiko Tatsumi et al.   GLIA

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

(2014) Gergely Horváth et al.   NEUROBIOLOGY OF DISEASE

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

(2013) Nitish Mittal et al.   Cell Reports

Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury

(2012) Kimiko Kobayashi et al.   GLIA

Distinct Degree of Radiculopathy at Different Levels of Peripheral Nerve Injury

(2012) Noboru Takiguchi et al.   Molecular Pain

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain

(2010) Eiji Yoshimi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE