Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 114, Issue 1, Pages 119-122Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10158SC
Keywords
Rho kinase; monoiodoacetate-induced arthritis; streptozotocin-induced neuropathy
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To assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. Although single dosing of AS1892802 exerted a short-acting, moderate analgesic effect, repeated dosing exhibited a long-lasting and more potent analgesic effect in both models. Furthermore, the analgesic effect was sustained for seven days after the last administration. These results suggest that peripheral ROCK plays a crucial role in chronic pain maintenance and that AS1892802 may be useful in treating chronic pain.
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