Flavones hydroxylated at 5, 7, 3′ and 4′ ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity

Quercetin and related flavonoids conserve their antioxidant properties despite undergoing chemical or enzymatic oxidation

(2017) Elías Atala et al.   FOOD CHEMISTRY

Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway

(2016) Yifan Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-β/Smad2/3 signalling pathway

(2015) Y.F. Zhang et al.   BRITISH JOURNAL OF DERMATOLOGY

Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

(2015) Yujun Wang et al.   CANCER LETTERS

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

(2015) Cornel Balta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5)

(2015) Harun M. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

(2015) Jon M. Carthy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of ALK5 inhibitor via structure-based virtual screening and ADMET prediction

(2015) Aibin Lin et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Intake of dietary flavonoids and risk of epithelial ovarian cancer

(2014) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hypertrophic Burn Scar Management

(2014) Jonathan S. Friedstat et al.   ANNALS OF PLASTIC SURGERY

Immunohistochemical analysis of neuropeptides (protein gene product 9.5, substance P and calcitonin gene-related peptide) in hypertrophic burn scar with pain and itching

(2014) In Suk Kwak et al.   BURNS

An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial–mesenchymal transition

(2014) Chul-Yong Park et al.   CANCER LETTERS

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

(2014) Yixi Xie et al.   CURRENT MEDICINAL CHEMISTRY

Therapeutic potential of morin against liver fibrosis in rats: Modulation of oxidative stress, cytokine production and nuclear factor kappa B

(2014) Gehan H. Heeba et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Baicalin Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via the AKT/HIF-1α/p27-Associated Pathway

(2014) Lin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Salinomycin and Other Polyether Ionophores Are a New Class of Antiscarring Agent

(2014) Collynn F. Woeller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Activity Association of Flavonoids in Lung Diseases

(2014) João Lago et al.   MOLECULES

Quercetin Promotes Neuronal and Behavioral Recovery by Suppressing Inflammatory Response and Apoptosis in a Rat Model of Intracerebral Hemorrhage

(2014) Yifan Zhang et al.   NEUROCHEMICAL RESEARCH

TGF-β1/Smad Signaling Pathway Regulates Epithelial-to-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma: In Vitro and Clinical Analyses of Cell Lines and Nomadic Kazakh Patients from Northwest Xinjiang, China

(2014) Lijuan Pang et al.   PLoS One

Protective effect of baicalein on renal ischemia/reperfusion injury in the rat

(2014) Kefei Wu et al.   RENAL FAILURE

Quantitating Skin Fibrosis: Innovative Strategies and Their Clinical Implications

(2014) Giuseppina Abignano et al.   Current Rheumatology Reports

Decreased Interleukin-20 Expression in Scleroderma Skin Contributes to Cutaneous Fibrosis

(2014) Hideo Kudo et al.   Arthritis & Rheumatology

The role of microRNAs in skin fibrosis

(2013) Olubukola Babalola et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents

(2013) Olubukola Babalola et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models

(2013) Shashank Kumar et al.   BMC Complementary and Alternative Medicine

ALK1-Smad1/5 signaling pathway in fibrosis development: Friend or foe?

(2013) José M. Muñoz-Félix et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions

(2013) Johanna Canady et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis

(2012) Hiroyuki Yano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

(2012) Li Xiao   Frontiers in Bioscience-Landmark

A Peptide Derived from Endostatin Ameliorates Organ Fibrosis

(2012) Y. Yamaguchi et al.   Science Translational Medicine

Fibrosis and immune dysregulation in systemic sclerosis

(2010) Carlo Chizzolini et al.   AUTOIMMUNITY REVIEWS

Mechanisms of skin fibrosis in systemic sclerosis

(2010) Masatoshi JINNIN   JOURNAL OF DERMATOLOGY

Radiotherapy Suppresses Angiogenesis in Mice through TGF-βRI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

(2010) Natsuko Imaizumi et al.   PLoS One

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

(2009) Katharine H. Wrighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY