Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53

Cereblon suppresses the lipopolysaccharide-induced inflammatory response by promoting the ubiquitination and degradation of c-Jun

(2018) Jing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway

(2018) Charlotte C. Bavley et al.   JOURNAL OF NEUROSCIENCE

CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory

(2018) Tianyu Song et al.   PLoS Genetics

The interacting domains in cereblon differentially modulate the immunomodulatory drug-mediated ubiquitination and degradation of its binding partners

(2018) Jing Tao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner

(2017) Liang Zhou et al.   HUMAN MOLECULAR GENETICS

A missense mutation in the CRBN gene that segregates with intellectual disability and self-mutilating behaviour in a consanguineous Saudi family

(2017) Atia Sheereen et al.   JOURNAL OF MEDICAL GENETICS

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death

(2017) Qiuting Yan et al.   MOLECULAR PHARMACOLOGY

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBNand Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

(2016) Dolores Del Prete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic regulation ofKcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+T-cell activation

(2016) Jung-Ah Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6

(2016) Yoon Min et al.   Cell Death & Disease

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells

(2015) Xiao-ou Hou et al.   ACTA PHARMACOLOGICA SINICA

Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice

(2015) Jia-yuan Wu et al.   ACTA PHARMACOLOGICA SINICA

Etoposide induces cell death via mitochondrial-dependent actions of p53

(2015) Sarwat Jamil et al.   Cancer Cell International

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

(2015) Jing Lu et al.   CHEMISTRY & BIOLOGY

Modulation of cereblon levels by anti-myeloma agents

(2015) Elena Díaz-Rodríguez et al.   LEUKEMIA & LYMPHOMA

The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels

(2015) Yi-An Chen et al.   Scientific Reports

Autophagy as the effector and player in DNA damage response of cells to genotoxicants

(2015) Shi-Meng Zhang et al.   Toxicology Research

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

(2014) Roman Alpatov et al.   CELL

p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine

(2014) Liang Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRL4ACRBN E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis

(2014) Jiye Liu et al.   Nature Communications

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

(2013) Liang Zhou et al.   ACTA PHARMACOLOGICA SINICA

Coordination of autophagy with other cellular activities

(2013) Yan Wang et al.   ACTA PHARMACOLOGICA SINICA

A Mental Retardation-linked Nonsense Mutation in Cereblon Is Rescued by Proteasome Inhibition

(2013) Guoqiang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

(2012) A Lopez-Girona et al.   LEUKEMIA

Behavioral characterization of cereblon forebrain-specific conditional null mice: A model for human non-syndromic intellectual disability

(2011) Anjali M. Rajadhyaksha et al.   BEHAVIOURAL BRAIN RESEARCH

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

(2011) Y. X. Zhu et al.   BLOOD

The clinical impact and molecular biology of del(17p) in multiple myeloma treated with conventional or thalidomide-based therapy

(2011) Kevin D. Boyd et al.   GENES CHROMOSOMES & CANCER

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

(2011) Haigang Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

(2011) Ildiko Hajdu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mitochondrial Apoptotic Events by p53-mediated Disruption of Complexes between Antiapoptotic Bcl-2 Members and Bim

(2010) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

(2009) Jeffrey Hannah et al.   DNA REPAIR

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

(2008) Sonja Wolff et al.   CELL RESEARCH

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE

Cellular Concentrations of DDB2 Regulate Dynamic Binding of DDB1 at UV-Induced DNA Damage

(2008) S. Alekseev et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 is required for etoposide-induced apoptosis of human embryonic stem cells

(2007) C. Grandela et al.   Stem Cell Research