Article
Chemistry, Multidisciplinary
Xiangang Huang, Gongwei Wu, Chuang Liu, Xianwu Hua, Zhongmin Tang, Yufen Xiao, Wei Chen, Jun Zhou, Na Kong, Peng Huang, Jinjun Shi, Wei Tao
Summary: This study presents a novel approach using an intercalation-driven siRNA nanogels (NG) as a delivery vehicle, which demonstrates good stability and efficient intracellular delivery for cancer therapy.
Article
Chemistry, Physical
Ali Molaei Aghdam, Nima Mikaeili Chahartagh, Shahriar Namvar, Mahshid Ershadi, Farshad Boorboor Ajdari, Ehsan Delfani
Summary: Layered materials are attractive cathodes for aqueous zinc-ion batteries (AZIBs) due to their simplified 2D Zn2+ transport channels. However, their weak cycle stability and limited capacity hinder practical applications. This study successfully evolved a SnS2 cathode with improved stability and capacity for AZIBs by modifying its layered structure. The findings provide new opportunities for developing high-performance cathodes for AZIBs using 2D materials.
JOURNAL OF MATERIALS CHEMISTRY A
(2024)
Article
Chemistry, Medicinal
Kritika Laxmikeshav, Mone Sayali, Geetanjali Devabattula, Durgesh G. G. Valapil, Ashutosh Mahale, Pravesh Sharma, Joel George, Regur Phanindranath, Chandraiah Godugu, Onkar P. P. Kulkarni, Narayana Nagesh, Nagula Shankaraiah
Summary: A simple click protocol was used to synthesize 1,2,3-triazole-linked benzimidazoles as potential anticancer agents, which showed significant cytotoxicity against SK-Mel-28 cancer cells and no cytotoxicity against normal BEAS-2B cells. Compound 12j inhibited cellular migration, colony formation, and induced apoptosis in SK-Mel-28 cells.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Multidisciplinary
Fei Wang, Zhendong Liu, Zhijie Xiang, Chengzhi Zhang, Anbang Lu, Fulai Qi, Jun Tan, Jinshui Liu
Summary: Efficient three-dimensional spatial charge transfer is crucial for improving the storage kinetics of alkali metal ion batteries. In this study, a novel approach of regulating the sp(2)-hybrid carbon skeleton within 3D penetration structures was developed by introducing delocalized (CS)-S-= groups. The resulting carbon skeleton exhibited superior electronic and atomic structural properties, facilitating efficient 3D charge transfer and fast electrochemical kinetics in potassium-ion batteries.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Sarmin Hamidi, Kasra Askari, Pejman Salimi
Summary: A simple synthesis approach is suggested to obtain expanded graphite from natural graphite precursors via thermal treatment. The structural, morphological, and electrochemical properties of TEG indicate its potential as an anode electrode for both conventional and beyond lithium-ion batteries (LIBs).
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chun Gui, Edward Kalkreuter, Yu-Chen Liu, Ajeeth Adhikari, Christiana N. Teijaro, Dong Yang, Changsoo Chang, Ben Shen
Summary: This study investigates the biosynthetic mechanism of anthraquinone-fused enediynes. By identifying and characterizing the enzyme TnmK1, it reveals a new way of forming chemical bonds in these molecules. Additionally, an intermediate with potential anti-cancer activity was discovered. These findings are important for enzymology, natural product biosynthesis, and drug development.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Rong Jin, Minqiang Wang, Liefu Zhou, Zhengshi Yang, Qing Chang, Aoneng Cao
Summary: Polymeric nanogels from clickable dextran prodrugs were designed for pH-responsive drug release against solid tumors. The nanogels showed slow DOX release under physiological conditions and faster release in an acidic environment. In vitro and in vivo studies demonstrated significant antitumor activity and improved drug accumulation for the nanogels compared to free DOX, highlighting their potential for cancer chemotherapy.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Tao Xu, Dimitrios Skoulas, Dawei Ding, Sally-Ann Cryan, Andreas Heise
Summary: In this study, responsive biocompatible nanogels were synthesized for controlled mucosal delivery and release of drugs. The nanogels exhibited suitable size and morphology, and showed responsiveness to reducing agents in the intracellular environment. This work provides a new approach for drug delivery in anti-cancer therapy by overcoming mucosal barriers.
Article
Chemistry, Multidisciplinary
Yuhang Huang, Shangyu Li, Logan W. C. Zettle, Yingshan Ma, Hani E. E. Naguib, Eugenia Kumacheva
Summary: Chronic wounds show high levels of cell-free deoxyribonucleic acid (cfDNA), leading to prolonged inflammation and non-healing wounds. Nanogels derived from chitosan and poly{2-[(acryloyloxy)ethyl]trimethylammonium chloride} were found to scavenge cfDNA efficiently due to their positive charge and network structure. The enhanced cfDNA scavenging ability and biocompatibility of the nanogels make them a promising component for chronic wound dressings.
Article
Chemistry, Physical
Na Li, Ming-Zi Sun, Sooyeon Hwang, Shuang Li, Hong-Yang Zhao, Ya-Ping Du, Bo-Long Huang, Dong Su
Summary: Graphite is considered the most important anode material for lithium-ion batteries due to its 2D structure allowing for ionic intercalation. Through in situ transmission electron microscopy, the real-time intercalation process of Li ions was observed at the atomic scale, revealing the formation of wrinkles and cracks in graphite layers as Li ions accumulate. The non-equilibrium behavior of Li-ion migration into irreversible wrinkled structures can degrade the capacity of graphite-based energy-storage devices, especially at high charging rates.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Multidisciplinary
Disraeli N. M. Kusmus, Thijs W. van Veldhuisen, Anzar Khan, Jeroen J. L. M. Cornelissen, Jos M. J. Paulusse
Summary: This study focuses on the controlled synthesis of functional nanogels, such as epoxide-functional nanogels, and demonstrates how the size of the nanogels can be controlled by the degree of polymerization.
Article
Multidisciplinary Sciences
Yecun Wu, Jingyang Wang, Yanbin Li, Jiawei Zhou, Bai Yang Wang, Ankun Yang, Lin-Wang Wang, Harold Y. Hwang, Yi Cui
Summary: The authors stabilize the intermediate phase in twisted bilayer MoS2, leveraging the Moire potential, which facilitates fast Li diffusion and uniform intercalation. This provides insight into non-uniform intercalation during battery charging and discharging, and opens up new opportunities for modulating the properties of 2D materials with guest species doping in Moire structures.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Haiyan Sui, Shuli Dong, Peiyu Zhang, Jingcheng Hao
Summary: Emulsion polymerization techniques can be used for the synthesis of polymer nanogels. By controlling various parameters, monodispersed nanogels with desired size can be obtained. This study contributes to the applications of nanogels in controlled drug release, tissue engineering, and regenerative medicine.
CHEMICAL PHYSICS LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Sarthak Jhingran, Kritika Laxmikeshav, Sayali Mone, Venkata K. Rao, Nagula Shankaraiah
Summary: Cancer, as a global health issue, poses a significant threat to human lives. DNA, being one of the major targets in cancer chemotherapy, can be effectively targeted by phenanthrene and its derivatives through intercalation and inhibition of DNA synthesis enzymes. However, the development of novel chemotherapeutic agents is crucial due to off-target effects and resistance. This review summarizes the recent progress in the development of phenanthrene-based derivatives, focusing on synthetic strategies, conjugation with other pharmacophores, and metal complexes. The cytotoxicity evaluation against various carcinoma cell lines and computational studies are also discussed, highlighting the potential of these derivatives as cytotoxic agents in medicinal chemistry.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Aysun Degirmenci, Hazal Ipek, Rana Sanyal, Amitav Sanyal
Summary: Among various nanoscale drug delivery systems, biodegradable polymeric nanogels present a viable platform for targeted cancer therapy. The fabrication of modular redox-responsive nanogel system through host-guest interaction-directed self-assembly of dextran-based polymers is reported here. The nanogels showed enhanced drug release and cytotoxicity against cancer cells, especially in a glutathione-enriched environment.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick Winnersbach, Jan Rossaint, Eva M. Buhl, Smriti Singh, Jonas Lolsberg, Matthias Wessling, Rolf Rossaint, Christian Bleilevens
Summary: The study demonstrated that reducing PLTs within an ECMO system is associated with limited PLT activation and NET formation, reducing clot stability but not sufficient to inhibit clot formation per se. Both PLT- and PLT+ groups showed equal clot formation within the ECMO circuit, indicating that PLT reduction may help mitigate clotting complications.
Article
Nanoscience & Nanotechnology
Fabian Obstals, Lena Witzdam, Manuela Garay-Sarmiento, Nina Yu Kostina, Jonas Quandt, Rolf Rossaint, Smriti Singh, Oliver Grottke, Cesar Rodriguez-Emmenegger
Summary: Nature utilizes endothelium to control hemostasis and prevent thrombosis. A study reports an ultrathin antifouling fibrinolytic coating that can self-regulate thrombus disintegration, providing a potential solution for preventing thromboembolic complications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Elizaveta Selezneva, Artem Bakirov, Nikita G. Sedush, Aleksandra Bystrova, Sergei N. Chvalun, Dan E. Demco, Martin Moeller
Summary: The study on self-healing polymer materials faces challenges in repairing large-scale defects and requiring the healing process to be generated by the scission itself. The described blend structure includes three types of cross-links, which can homogeneously mix above the melting point and exhibit shape memory effect when heated.
Article
Biochemistry & Molecular Biology
Stefan Mommer, David Gehlen, Takami Akagi, Mitsuru Akashi, Helmut Keul, Martin Moeller
Summary: Functionalized pullulan with thiolactones allows for cross-linking with diamines and/or amine-containing biological substrates, enhancing versatility for cell proliferation. Studies show that gelatin and GRGDS equally support proliferation of normal human dermal fibroblasts, while GRGDS and GHK significantly improve proliferation of hepatocytes. The strategy of producing biogels using biologically active substrates as cross-linkers is confirmed to be mild and biocompatible.
Article
Chemistry, Physical
Ahmed Mourran, Oliver Jung, Rostislav Vinokur, Martin Moller
Summary: The study demonstrates a system that mimics swimming by microorganisms through simple design principles, using pulsed infrared light irradiation to drive a microswimmer via fast temperature changes. The construction and motion modes of the microswimmer are controlled by plasmonic heating, allowing the ribbons to move at a rate of 6 body length/s with different modes of motion within a confined space.
EUROPEAN PHYSICAL JOURNAL E
(2021)
Article
Engineering, Environmental
Fuat Topuz, Mahmoud A. Abdulhamid, Rifan Hardian, Tibor Holtzl, Gyorgy Szekely
Summary: The study demonstrated the successful fabrication of nanofibrous air-filtration membranes using intrinsically microporous polyimide with metal-organic frameworks (MOFs), showing efficient removal of VOCs from air. Different polyimides with varying surface areas were synthesized, and the impact of porosity on the sorption kinetics of nanofibers was investigated. Embedding Zr-based MOFs into nanofibers greatly improved the sorption performance for both polar and non-polar VOCs, with molecular modeling studies clarifying the interactions between VOCs and polymer/MOFs. Additionally, the practicality and applicability of the material were assessed by modifying industrial N95 dust masks.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Patrick Winnersbach, Aisa Hosseinnejad, Thomas Breuer, Tamara Fechter, Felix Jakob, Ulrich Schwaneberg, Rolf Rossaint, Christian Bleilevens, Smriti Singh
Summary: Endogenously NO-releasing microgel coating inhibits platelet activation and reduces clot formation under dynamic flow conditions.
Article
Chemistry, Multidisciplinary
Prachi Desai, Rahul Rimal, Alexandru Florea, Rustam A. Gumerov, Marta Santi, Anastasia S. Sorokina, Sabri E. M. Sahnoun, Thorsten Fischer, Felix M. Mottaghy, Agnieszka Morgenroth, Ahmed Mourran, Igor I. Potemkin, Martin Moeller, Smriti Singh
Summary: This study demonstrates that by tuning the mechanical properties of nanogels, significant enhancement in their circulation time can be achieved, leading to improved radiation damage to tumor cells. The results show that small changes in the mechanical properties of nanogels influence their fate inside cells, which is confirmed by PET/CT and computer simulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Lysann Kassner, Xiaomin Zhu, Karola Schaefer, Zhi Chen, Martin Moeller, Tina Uhlig, Frank Simon, Doreen Dentel, Christoph Tegenkamp, Stefan Spange, Michael Mehring
Summary: Coating textile fibers with nanostructured organic-inorganic hybrid materials can improve their hydrophobicity, solvent resistance, and mechanical properties. By adjusting the ratio of organic and inorganic components, the performance of the coating can be controlled. The coating process can also be combined with other polymerization processes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
J. Robin Hoehner, Rustam A. Gumerov, Igor I. Potemkin, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Ahmed Mourran, Jenny Englert, David Schroeter, Lennart Janke, Martin Moeller
Summary: The study focuses on the synthesis of hydrophilic arborescent polymers with high conformational flexibility through grafting-from procedure, showing a strong interfacial activity in liquid-liquid interfaces. The molecules exhibit globular conformation and maintain a high flexibility, contributing to their unique behavior in toluene-in-water suspensions.
Review
Chemistry, Multidisciplinary
Prachi Desai, Rahul Rimal, Sabri E. M. Sahnoun, Felix M. Mottaghy, Martin Moller, Agnieszka Morgenroth, Smriti Singh
Summary: Endogenous targeted radiotherapy has side effects, and the use of nanocarriers can mitigate these effects. Nanocarriers have advantages of prolonging circulation time, increasing tumor retention, and offering multifunctionality for targeting strategies.
Review
Biochemistry & Molecular Biology
[Anonymous]
Summary: Advancements in tissue engineering have led to the understanding of physiological basement membranes. Efforts have been made to synthesize biomimetic membranes for applications in organ models.
Article
Chemistry, Physical
A. A. Stupnikov, A. V. Bakirov, M. A. Shcherbina, U. Beginn, M. Moeller, S. N. Chvalun
Summary: Wedge-shaped dendrons based on benzenesulfonic acid can form different liquid crystal mesophases, such as ordered and disordered columnar hexagonal ones. The size and nature of focal groups as well as the length of aliphatic tails are important factors affecting the phase behavior of these materials. The study found that certain dendrons can form a 2D columnar ordered hexagonal mesophase with three annuli: a central channel, virtually hollow channel, and rigid aromatic part enveloped by an aliphatic matrix. The material shows promise for creating temperature-controlled ion-selective membranes.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Polymer Science
Chunchen Zhang, Dan Eugen Demco, Rahul Rimal, Jens Koehler, Rostislav Vinokur, Smriti Singh, Jan Tenbusch, Martin Moeller
Summary: This study demonstrates the reversible formation of hydrogels through hydrophobic interaction using poly(N-alkyl-N-vinylacetamide)s. The polymers with different lengths of alkyl chains can dissolve in ethanol and form thin films. When immersed in water, they swell and form biocompatible hydrogels. The hydrophobic association varies with the length of the alkyl substituents, with shorter chains leading to flowable hydrogels that segregate from excess water and longer chains yielding hydrogels with mechanical properties similar to permanently cross-linked hydrogels.
Article
Chemistry, Physical
Thorsten Fischer, Jan Tenbusch, Martin Moeller, Smriti Singh
Summary: The use of polymeric materials with controlled surface properties is important in biomedical applications. This study presents a method to graft highly stable, ultra-thin, amine-functional hydrogel layers onto inert surfaces of certain polymers. The covalently bound surface layers resist extraction and exhibit both hydrophobic and hydrophilic wetting behavior.
