Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones

Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones

(2015) Karuppusamy Raja et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thyroid hormones-From Crystal Packing to Activity to Reactivity

(2015) Ulrich Schweizer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure Elucidation and Characterization of Different Thyroxine Polymorphs

(2015) Santanu Mondal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selenium-Mediated Dehalogenation of Halogenated Nucleosides and its Relevance to the DNA Repair Pathway

(2015) Santanu Mondal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling

(2015) V. Catalano et al.   CANCER RESEARCH

Halogen Bonding in Supramolecular Chemistry

(2015) Lydia C. Gilday et al.   CHEMICAL REVIEWS

Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones

(2015) Doreen Braun et al.   ENDOCRINOLOGY

Biosynthesis of 3-Iodothyronamine From T4in Murine Intestinal Tissue

(2015) Carolin S. Hoefig et al.   ENDOCRINOLOGY

3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice

(2015) Wenke Jonas et al.   ENDOCRINOLOGY

New insights into the structure and mechanism of iodothyronine deiodinases

(2015) Ulrich Schweizer et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

3-iodothyronamine differentially modulates  -2A-adrenergic receptor-mediated signaling

(2015) J. Dinter et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Thyroid hormone transporters—functions and clinical implications

(2015) Juan Bernal et al.   Nature Reviews Endocrinology

Pendrin and anoctamin as mediators of apical iodide efflux in thyroid cells

(2015) Jamile C. Silveira et al.   Current Opinion in Endocrinology Diabetes and Obesity

Mode of binding of the antithyroid drug propylthiouracil to mammalian haem peroxidases

(2015) R. P. Singh et al.   Acta Crystallographica Section F-Structural Biology Communications

Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte

(2014) L. Twyffels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regioselective Deiodination of Iodothyronamines, Endogenous Thyroid Hormone Derivatives, by Deiodinase Mimics

(2014) Santanu Mondal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Halogen Bonding Controls the Regioselectivity of the Deiodination of Thyroid Hormones and their Sulfate Analogues

(2014) Debasish Manna et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Na+/I−Symporter (NIS): Mechanism and Medical Impact

(2014) Carla Portulano et al.   ENDOCRINE REVIEWS

ENDOCRINE SIDE-EFFECTS OF ANTI-CANCER DRUGS: Thyroid effects of tyrosine kinase inhibitors

(2014) Frédéric Illouz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Crystal structure of mouse mu-crystallin complexed with NADPH and the T3 thyroid hormone

(2014) Franck Borel et al.   FEBS Journal

Mutations in thePendred Syndrome(PDS/SLC26A) Gene: An Increasingly Complex Phenotypic Spectrum From Goiter to Thyroid Hypoplasia

(2014) Peter Kopp   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations of the Thyroid Hormone Transporter MCT8 Cause Prenatal Brain Damage and Persistent Hypomyelination

(2014) Daniela López-Espíndola et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Administration of 3,5‐diiodothyronine (3,5‐T2) causes central hypothyroidism and stimulates thyroid‐sensitive tissues

(2014) Alvaro Souto Padron et al.   JOURNAL OF ENDOCRINOLOGY

In Vitro and Mouse Studies Supporting Therapeutic Utility of Triiodothyroacetic Acid in MCT8 Deficiency

(2014) Simone Kersseboom et al.   MOLECULAR ENDOCRINOLOGY

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors

(2014) Michelle A. Maynard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

(2014) U. Schweizer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mutation in the Albumin Gene (R218S) Causing Familial Dysalbuminemic Hyperthyroxinemia in a Family of Bangladeshi Extraction

(2014) Solomon Maximo Greenberg et al.   THYROID

Antithyroid Drugs and Their Analogues: Synthesis, Structure, and Mechanism of Action

(2013) Debasish Manna et al.   ACCOUNTS OF CHEMICAL RESEARCH

Secisbp2 Is Essential for Embryonic Development and Enhances Selenoprotein Expression

(2013) Sandra Seeher et al.   ANTIOXIDANTS & REDOX SIGNALING

Excess Thyroid Hormone and Carbohydrate Metabolism

(2013) Matthew Potenza et al.   Endocrine Practice

Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8)

(2013) Doreen Braun et al.   ENDOCRINOLOGY

Type 3 deiodinase and solid tumors: an intriguing pair

(2013) Monica Dentice et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

A Redundant Role of Human Thyroid Peroxidase Propeptide for Cellular, Enzymatic, and Immunological Activity

(2013) Marlena Godlewska et al.   THYROID

Structure–activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity

(2013) Ryo Shimizu et al.   TOXICOLOGY

Thyroid Function Is Maintained Despite Increased Oxidative Stress in Mice Lacking Selenoprotein Biosynthesis in Thyroid Epithelial Cells

(2012) Jazmin Chiu-Ugalde et al.   ANTIOXIDANTS & REDOX SIGNALING

Function of thyroid hormone transporters in the central nervous system

(2012) Ulrich Schweizer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The syndromes of reduced sensitivity to thyroid hormone

(2012) Alexandra M. Dumitrescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

(2012) Kostja Renko et al.   ENDOCRINOLOGY

Finding the Way into the Brain without MCT8

(2012) W. Edward Visser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms of thyroid hormone action

(2012) Gregory A. Brent   JOURNAL OF CLINICAL INVESTIGATION

Selective Thyromimetics Using Receptor and Tissue Selectivity Approaches: Prospects for Dyslipidemia

(2012) Amit A. Joharapurkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding

(2012) Debasish Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical Phenotype and Mutant TRα1

(2012) Alies van Mullem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disorders of selenium metabolism and selenoprotein function

(2011) Ulrich Schweizer et al.   CURRENT OPINION IN PEDIATRICS

Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy

(2011) Eva K Wirth et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid-binding Globulins

(2011) Xiaoqiang Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Kinase Inhibitors Noncompetitively Inhibit MCT8-Mediated Iodothyronine Transport

(2011) Doreen Braun et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity?

(2011) Debasish Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Does the aromatic l-amino acid decarboxylase contribute to thyronamine biosynthesis?

(2011) Carolin S. Hoefig et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Mutation in the Thyroid Hormone Receptor Alpha Gene

(2011) Elena Bochukova et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)

(2011) M. Paroder-Belenitsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Halogenated Phenolic Contaminants Inhibit the In Vitro Activity of the Thyroid-Regulating Deiodinases in Human Liver

(2011) Craig M. Butt et al.   TOXICOLOGICAL SCIENCES

A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase

(2010) Debasish Manna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment

(2010) Matthew L. Rosene et al.   ENDOCRINOLOGY

Adaptations of the Autonomous Nervous System Controlling Heart Rate Are Impaired by a Mutant Thyroid Hormone Receptor-α1

(2010) Jens Mittag et al.   ENDOCRINOLOGY

Is Halogen Bonding the Basis for Iodothyronine Deiodinase Activity?

(2010) Craig A. Bayse et al.   INORGANIC CHEMISTRY

Inhibition of peroxidase-catalyzed protein tyrosine nitration by antithyroid drugs and their analogues

(2010) Krishna P. Bhabak et al.   INORGANICA CHIMICA ACTA

Essential Molecular Determinants for Thyroid Hormone Transport and First Structural Implications for Monocarboxylate Transporter 8

(2010) Anita Kinne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liganded Thyroid Hormone Receptor-α Enhances Proliferation of Pancreatic β-Cells

(2010) Fumihiko Furuya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

(2010) Caterina Di Cosmo et al.   JOURNAL OF CLINICAL INVESTIGATION

TRβ is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells

(2010) Marta A. Kowalik et al.   JOURNAL OF HEPATOLOGY

Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations

(2010) José C. Moreno et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modeling of the 5′-Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate

(2009) Kei Goto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Syndrome of Inherited Partial SBP2 Deficiency in Humans

(2009) Alexandra M. Dumitrescu et al.   ANTIOXIDANTS & REDOX SIGNALING

Familial Dysalbuminemic Hyperthyroxinemia: A Persistent Diagnostic Challenge

(2009) D. Cartwright et al.   CLINICAL CHEMISTRY

Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-β Isoform Specific and Required for Adaptive Thermogenesis

(2009) Miriam O. Ribeiro et al.   ENDOCRINOLOGY

Screening for mutations of the human thyroid peroxidase gene in patients with congenital hypothyroidism

(2009) A. Grüters et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands

(2009) Seth R. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegansand Human Dual Oxidase 1 (DUOX1) “Peroxidase” Domains

(2009) Jennifer L. Meitzler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Dual Oxidases Duox1 and Duox2

(2009) Sabrina Rigutto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity

(2009) David O. McDonald et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Neuronal 3',3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan-Herndon-Dudley Syndrome

(2009) E. K. Wirth et al.   JOURNAL OF NEUROSCIENCE

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

(2009) Torsten K Roepke et al.   NATURE MEDICINE

Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes

(2009) John D. Baxter et al.   NATURE REVIEWS DRUG DISCOVERY

Gaining ligand selectivity in thyroid hormone receptors via entropy

(2009) L. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses

(2008) Nicholas Frank et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Halogen Bonding in Supramolecular Chemistry

(2008) Pierangelo Metrangolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peroxides and Peroxide-Degrading Enzymes in the Thyroid

(2008) Ulrich Schweizer et al.   ANTIOXIDANTS & REDOX SIGNALING

Iodothyronamines are Oxidatively Deaminated to Iodothyroacetic Acids in vivo

(2008) Warren J. L. Wood et al.   CHEMBIOCHEM

Radioiodine therapy (RAI) for Graves’ disease (GD) and the effect on ophthalmopathy: a systematic review*

(2008) Shamasunder H. Acharya et al.   CLINICAL ENDOCRINOLOGY

Adjunctive interventions in myocardial infarction: The role of statin therapy

(2008) Peter H. Jones et al.   Current Atherosclerosis Reports

Thyronamines Are Isozyme-Specific Substrates of Deiodinases

(2008) S. Piehl et al.   ENDOCRINOLOGY

Genetics of crystallins: Cataract and beyond

(2008) Jochen Graw   EXPERIMENTAL EYE RESEARCH

Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

(2008) Andrea Perra et al.   FASEB JOURNAL

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

(2008) Edward E. Cable et al.   HEPATOLOGY

Antithyroid Drug Carbimazole and Its Analogues: Synthesis and Inhibition of Peroxidase-Catalyzed Iodination ofl-Tyrosine

(2008) Debasis Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141

(2008) Galina Bryzgalova et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effective Cellular Uptake and Efflux of Thyroid Hormone by Human Monocarboxylate Transporter 10

(2008) Edith C. H. Friesema et al.   MOLECULAR ENDOCRINOLOGY

The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer

(2008) G. D. Vivek Sagar et al.   MOLECULAR ENDOCRINOLOGY

Mutations in the Iodotyrosine Deiodinase Gene and Hypothyroidism

(2008) José C. Moreno et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Thyroid Hormone Analogs on Lipid Metabolism and Thermogenesis

(2008) Miriam O. Ribeiro   THYROID