New insights into the structure and mechanism of iodothyronine deiodinases

Structure Elucidation and Characterization of Different Thyroxine Polymorphs

(2015) Santanu Mondal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice

(2015) Wenke Jonas et al.   ENDOCRINOLOGY

The variable region of iodothyronine deiodinases directs their catalytic properties and subcellular localization

(2015) Aurora Olvera et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

Halogen Bonding Controls the Regioselectivity of the Deiodination of Thyroid Hormones and their Sulfate Analogues

(2014) Debasish Manna et al.   CHEMISTRY-A EUROPEAN JOURNAL

3,5-Diiodothyronine (T2) is on a role. A new hormone in search of recognition

(2014) Aurea Orozco et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

A Switch between One- and Two-electron Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase Is Controlled by Substrate

(2014) Jimin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation

(2014) Karl A. P. Payne et al.   NATURE

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

(2014) U. Schweizer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for organohalide respiration

(2014) Martin Bommer et al.   SCIENCE

Type 3 Deiodinase: Role in Cancer Growth, Stemness, and Metabolism

(2014) Domenico Ciavardelli et al.   Frontiers in Endocrinology

Antithyroid Drugs and Their Analogues: Synthesis, Structure, and Mechanism of Action

(2013) Debasish Manna et al.   ACCOUNTS OF CHEMICAL RESEARCH

3,5-T2Is an Alternative Ligand for the Thyroid Hormone Receptor β1

(2013) A. Mendoza et al.   ENDOCRINOLOGY

Type 3 deiodinase and solid tumors: an intriguing pair

(2013) Monica Dentice et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structure–activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity

(2013) Ryo Shimizu et al.   TOXICOLOGY

The propylthiouracil dilemma

(2013) Daniel Glinoer et al.   Current Opinion in Endocrinology Diabetes and Obesity

The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation

(2012) Monica Dentice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

(2012) Kostja Renko et al.   ENDOCRINOLOGY

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation

(2012) Bo Zhu et al.   JOURNAL OF ENDOCRINOLOGY

Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding

(2012) Debasish Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nonselenoprotein from Amphioxus Deiodinates Triac But Not T3: Is Triac the Primordial Bioactive Thyroid Hormone?

(2011) Wim Klootwijk et al.   ENDOCRINOLOGY

Halogenated Phenolic Contaminants Inhibit the In Vitro Activity of the Thyroid-Regulating Deiodinases in Human Liver

(2011) Craig M. Butt et al.   TOXICOLOGICAL SCIENCES

A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase

(2010) Debasish Manna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comparison of Thiol Peroxidase Mechanisms

(2010) Leopold Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Efficient use and recycling of the micronutrient iodide in mammals

(2010) Steven E. Rokita et al.   BIOCHIMIE

Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment

(2010) Matthew L. Rosene et al.   ENDOCRINOLOGY

Is Halogen Bonding the Basis for Iodothyronine Deiodinase Activity?

(2010) Craig A. Bayse et al.   INORGANIC CHEMISTRY

Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations

(2010) José C. Moreno et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modeling of the 5′-Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate

(2009) Kei Goto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substitution of Serine for Proline in the Active Center of Type 2 Iodothyronine Deiodinase Substantially Alters Itsin VitroBiochemical Properties with Dithiothreitol But Not Its Function in Intact Cells

(2009) Iuri Martin Goemann et al.   ENDOCRINOLOGY

Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands

(2009) Seth R. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mammalian Reductive Deiodinase has Broad Power to Dehalogenate Chlorinated and Brominated Substrates

(2009) Patrick M. McTamney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thyronamines Are Isozyme-Specific Substrates of Deiodinases

(2008) S. Piehl et al.   ENDOCRINOLOGY

Think globally: Act locally

(2008) Ulrich Schweizer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer

(2008) G. D. Vivek Sagar et al.   MOLECULAR ENDOCRINOLOGY

Mutations in the Iodotyrosine Deiodinase Gene and Hypothyroidism

(2008) José C. Moreno et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates

(2008) Susanne Piehl et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY