Metal-Free [2+2+2] Cycloaddition of Ynamides and Nitriles: Mild and Regioselective Synthesis of Fully Substituted Pyridines

Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

(2016) Yu-Ling Chen et al.   CHEMICAL COMMUNICATIONS

Iridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Cyanamides

(2015) Toru Hashimoto et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams

(2015) Wanxiang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Pyridylphosphonates by Rhodium-Catalyzed [2+2+2] Cycloaddition of 1,6- and 1,7-Diynes with Diethyl Phosphorocyanidate

(2015) Kenichi Kashima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

(2015) Fen Xu et al.   GREEN CHEMISTRY

Ruthenium-Catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study

(2015) Jicheng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dehydrogenative [2 + 2 + 2] Cycloaddition of Cyano-yne-allene Substrates: Convenient Access to 2,6-Naphthyridine Scaffolds

(2015) Ewelina Haraburda et al.   ORGANIC LETTERS

Gold-catalyzed formal [4π + 2π]-cycloadditions of propiolate derivatives with unactivated nitriles

(2015) Somnath Narayan Karad et al.   Chemical Science

Gold-Catalyzed Synthesis of Functionalized Pyridines by Using 2H-Azirines as Synthetic Equivalents of Alkenyl Nitrenes

(2014) Agnes Prechter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regiocontrolled Gold-Catalyzed [2+2+2] Cycloadditions of Ynamides with Two Discrete Nitriles to Construct 4-Aminopyrimidine Cores

(2014) Somnath Narayan Karad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Free Multicomponent Syntheses of Pyridines

(2014) Christophe Allais et al.   CHEMICAL REVIEWS

Computational insight into Wilkinson's complex catalyzed [2 + 2 + 2] cycloaddition mechanism leading to pyridine formation

(2014) Òscar Torres et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Rh(III)-Catalyzed Decarboxylative Coupling of Acrylic Acids with Unsaturated Oxime Esters: Carboxylic Acids Serve as Traceless Activators

(2014) Jamie M. Neely et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

(2013) Jun Liang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modular Pyridine Synthesis from Oximes and Enals through Synergistic Copper/Iminium Catalysis

(2013) Ye Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Eight-Membered Lactones: Intermolecular [6+2] Cyclization of Amphoteric Molecules with Siloxy Alkynes

(2012) Wanxiang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Aminopyridines and Aminopyridones by Cobalt-Catalyzed [2+2+2] Cycloadditions Involving Yne-Ynamides: Scope, Limitations, and Mechanistic Insights

(2012) Pierre Garcia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2,2’-Bipyridines by Transition Metal-Catalyzed Alkyne/Nitrile [2 + 2 + 2] Cycloaddition Reactions

(2012) Sentaro Okamoto   HETEROCYCLES

Rhodium-Catalyzed [2+2+2] Cycloaddition for the Synthesis of Substituted Pyridines, Pyridones, and Thiopyranimines

(2012) Ken Tanaka   HETEROCYCLES

Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Nitriles

(2012) Gen Onodera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The hexadehydro-Diels–Alder reaction

(2012) Thomas R. Hoye et al.   NATURE

A Simple and Highly Efficient Iron Catalyst for a [2+2+2] Cycloaddition to Form Pyridines

(2011) Chunxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Serendipitous Discovery: Nickel Catalyst for the Cycloaddition of Diynes with Unactivated Nitriles

(2011) Puneet Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Cycloaddition of Alkynenitriles and Alkynes

(2011) Brendan R. D’Souza et al.   ORGANIC LETTERS

Construction of fused heterocycles by metal-mediated [2+2+2] cyclotrimerization of alkynes and/or nitriles

(2011) Mohamed R. Shaaban et al.   TETRAHEDRON

Ynamides: Versatile Tools in Organic Synthesis

(2010) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ynamides: A Modern Functional Group for the New Millennium

(2010) Kyle A. DeKorver et al.   CHEMICAL REVIEWS

Recent Strategies for the Synthesis of Pyridine Derivatives

(2010) Matthew D. Hill   CHEMISTRY-A EUROPEAN JOURNAL

Cyano Diels−Alder and Cyano Ene Reactions. Applications in a Formal [2 + 2 + 2] Cycloaddition Strategy for the Synthesis of Pyridines

(2010) Takeo Sakai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2,4-Diaminopyridine δ-opioid receptor agonists and their associated hERG pharmacology

(2009) Dafydd R. Owen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors

(2009) Minoru Kameda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Pd(II)-Catalyzed Ring-Expansion Reaction of Cyclic 2-Azidoalcohol Derivatives: Synthesis of Azaheterocycles

(2009) Shunsuke Chiba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thieme Chemistry Journal Awardees - Where Are They Now? Triflic Imide Catalyzed Cycloaddition Reactions

(2009) Kiyosei Takasu   SYNLETT