Article
Environmental Sciences
Ricardo Alves Bernardo, Jean Carlos Pereira Sousa, Matheus Gallimberti, Fernando Barbosa Junior, Boniek Gontijo Vaz, Andrea Rodrigues Chaves
Summary: Concerns over human health risks due to the use of bisphenol A in thermal papers have led to its replacement by bisphenol S. Analyzing bisphenols typically involves laborious and time-consuming steps, but a new paper spray ionization mass spectrometry (PSI-MS) method offers a faster and efficient alternative. The study found that bisphenol S concentrations in BPA-free thermal papers ranged from 1.36 to 6.77 mu g g(-1), while BPA concentrations in all samples of thermal paper ranged from 6.56 to 16.4 mu g g(-1).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Rebekah Gray, Eve Painter, Jameson W. Sprankle, Alex D. Crawford, Jillian J. Morrison, Marian Frazier, Jennifer A. Faust
Summary: In this study, liquid chromatography high-resolution mass spectrometry was used to screen for suspect pesticides in wet deposition for the first time. The presence of 23 pesticides, including three species never before quantified in wet deposition, was confirmed. The study reveals the transport and fate of pesticides in the atmosphere, providing important evidence for accurate modeling of the atmospheric transport and fate of these compounds.
ATMOSPHERIC ENVIRONMENT
(2022)
Article
Engineering, Environmental
Shiru Wang, Ruta Basijokaite, Bethany L. Murphy, Christa A. Kelleher, Teng Zeng
Summary: This work characterized complex mixtures of OMPs in streams draining mixed-use watersheds using passive sampling and liquid chromatography-high-resolution mass spectrometry. Suspect screening and nontarget screening identified a large number of OMPs, and POCIS was used to assist in OMP load estimation and screening-level risk assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Ian Oesterle, Manuel Pristner, Sabrina Berger, Mingxun Wang, Vinicius Verri Hernandes, Annette Rompel, Benedikt Warth
Summary: Polyphenols, abundant in plants and fungi, have beneficial bioactive properties. High-resolution mass spectrometry (HRMS) is favored for analyzing their complexity. This study evaluated the advantages of HRMS, using untargeted techniques and online resources, for annotating polyphenols and other molecules. Despite the sensitivity loss compared to low-resolution mass spectrometry (LRMS), HRMS is capable of comprehensively investigating human polyphenol exposure, linking it to human health effects and toxicological mixture effects with other xenobiotics.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Mikel Musatadi, Claudia Caballero, Leire Mijangos, Ailette Prieto, Maitane Olivares, Olatz Zuloaga
Summary: In this study, a target analysis method was developed to simultaneously determine 24 endocrine-disrupting compounds in urine samples. The method was optimized, validated, and applied to volunteers' samples, showing successful quantification of 67% of the target compounds. Additionally, suspect and non-target screening methods were developed using LC-MS/MS, allowing for the identification of various compounds in urine samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Lei Wang, Qinru Xiao, Mingdeng Yuan, Shaoyou Lu
Summary: In this study, extracts of food contact material (FCM) samples from South China were analyzed, revealing the presence of various organophosphate esters (OPEs) and organophosphite antioxidants (OPAs), some of which were identified for the first time. The study also investigated the migration risk of these compounds from FCMs to food, highlighting the importance of understanding their diversity and occurrences.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Chih-Wei Chang, Jen-Yi Hsu, Yu-Hsiang Su, Yuan-Chih Chen, Ping-Zu Hsiao, Pao-Chi Liao
Summary: Hair has emerged as a biospecimen for long-term chemical exposome studies, but is not widely adopted compared to blood and urine. In this study, a high-resolution mass spectrometry (HRMS)-based suspect screening strategy was used to characterize the chemical exposome in human hair. 587 suspect features were matched to 246 unique chemical formulas, and 167 chemicals were identified. Hair reflects the accumulation of environmental compounds, and hair analysis may be promising for monitoring long-term exposure to multiple environmental chemicals.
Article
Chemistry, Analytical
Reza Aalizadeh, Nikiforos A. Alygizakis, Emma L. Schymanski, Martin Krauss, Tobias Schulze, Maria Ibanez, Andrew D. McEachran, Alex Chao, Antony J. Williams, Pablo Gago-Ferrero, Adrian Covaci, Christoph Moschet, Thomas M. Young, Juliane Hollender, Jaroslav Slobodnik, Nikolaos S. Thomaidis
Summary: This study proposed a unified retention time index (RTI) approach for liquid chromatography, aiming to achieve comparable retention times among different laboratories. By calibrating the elution pattern with two sets of calibration compounds, the RTI range was set between 1 and 1000, which was considered the most appropriate RTI system after rigorous evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Huijun Su, Kefan Ren, Rongrong Li, Jianhua Li, Zhanqi Gao, Guanjiu Hu, Pingqing Fu, Guanyong Su
Summary: This study reviewed existing literature on liquid crystal monomers (LCMs) and established a database containing 1173 LCMs. The physicochemical properties of these LCMs were calculated, and a suspect screening strategy tailored for LCMs was successfully developed. This strategy has the potential to be applied to other environmental matrices.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Holly Barrett, Xuan Du, Magali Houde, Stephane Lair, Jonathan Verreault, Hui Peng
Summary: The study investigated the temporal trends of PFASs in beluga whales from the St. Lawrence Estuary in Canada from 2000 to 2017, finding that certain legacy PFASs decreased while unregulated short-chain PFAS alternatives increased over time. Suspect and nontarget screening revealed class-specific temporal trends of PFASs, confirming continuous emissions of unregulated PFASs into the environment. The study also highlighted the higher concentrations of PFASs in newborns and juveniles compared to adults due to potential placental and lactational transfer.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Yu Han, Li-Xin Hu, Ting Liu, Jing Liu, Yu-Qing Wang, Jia-Hui Zhao, You-Sheng Liu, Jian-Liang Zhao, Guang-Guo Ying
Summary: Landfill sites are considered a significant source of emerging chemicals in groundwater. However, our understanding of the composition of these chemicals in landfill leachate and adjacent groundwater is still limited. In this study, we used high-resolution mass spectrometry to investigate the presence of various chemicals in landfill leachates and groundwater in Guangzhou, China. We identified a wide range of chemicals, including pharmaceuticals, personal care products, food additives, industrial chemicals, pesticides, and other organic compounds. Our findings suggest that the chemicals in groundwater are likely to originate from landfill sites. This study highlights the importance of non-target screening in identifying these emerging chemicals and reveals the contamination risk posed by landfill leachate to groundwater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Solenne Reverbel, Marie-Helene Devier, Valentin Dupraz, Emmanuel Geneste, Helene Budzinski
Summary: This study developed an analytical method based on high resolution mass spectrometry (HRMS) to detect the presence of six psychotropic drugs, as well as their potential metabolites and transformation products (TPs), in wastewater treatment plants (WWTPs) in France. The results showed that four out of six psychotropic drugs and 25 to 37 potential TPs were detected in wastewater, including some TPs that have not been reported in the literature.
Article
Environmental Sciences
Nathalie Bonvallot, Emilien L. Jamin, Lucas Regnaut, Cecile Chevrier, Jean-Francois Martin, Fabien Mercier, Sylvaine Cordier, Jean-Pierre Cravedi, Laurent Debrauwer, Barbara Le Bot
Summary: The combined strategy of suspect screening and targeted analysis was used to identify multiple pesticide exposures in pregnant women. Suspect screening detected metabolites rarely studied and not measured in biomonitoring studies, while the targeted approach confirmed parent compounds and quantified commercially available or synthesizable compounds. The study found exposure determinants in both urban and rural areas, depending on the active substance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Hiba Mohammed Taha, Reza Aalizadeh, Nikiforos Alygizakis, Jean-Philippe Antignac, Hans Peter H. Arp, Richard Bade, Nancy Baker, Lidia Belova, Lubertus Bijlsma, Evan E. Bolton, Werner Brack, Alberto Celma, Wen-Ling Chen, Tiejun Cheng, Parviel Chirsir, L'ubos Cirka, Lisa A. D'Agostino, Yannick Djoumbou Feunang, Valeria Dulio, Stellan Fischer, Pablo Gago-Ferrero, Aikaterini Galani, Birgit Geueke, Natalia Glowacka, Juliane Gluge, Ksenia Groh, Sylvia Grosse, Peter Haglund, Pertti J. Hakkinen, Sarah E. Hale, Felix Hernandez, Elisabeth M-L Janssen, Tim Jonkers, Karin Kiefer, Michal Kirchner, Jan Koschorreck, Martin Krauss, Jessy Krier, Marja H. Lamoree, Marion Letzel, Thomas Letzel, Qingliang Li, James Little, Yanna Liu, David M. Lunderberg, Jonathan W. Martin, Andrew D. McEachran, John A. McLean, Christiane Meier, Jeroen Meijer, Frank Menger, Carla Merino, Jane Muncke, Matthias Muschket, Michael Neumann, Vanessa Neveu, Kelsey Ng, Herbert Oberacher, Jake O'Brien, Peter Oswald, Martina Oswaldova, Jaqueline A. Picache, Cristina Postigo, Noelia Ramirez, Thorsten Reemtsma, Justin Renaud, Pawel Rostkowski, Heinz Ruedel, Reza M. Salek, Saer Samanipour, Martin Scheringer, Ivo Schliebner, Wolfgang Schulz, Tobias Schulze, Manfred Sengl, Benjamin A. Shoemaker, Kerry Sims, Heinz Singer, Randolph R. Singh, Mark Sumarah, Paul A. Thiessen, Kevin Thomas, Sonia Torres, Xenia Trier, Annemarie P. van Wezel, Roel C. H. Vermeulen, Jelle J. Vlaanderen, Peter C. von der Ohe, Zhanyun Wang, Antony J. Williams, Egon L. Willighagen, David S. Wishart, Jian Zhang, Nikolaos S. Thomaidis, Juliane Hollender, Jaroslav Slobodnik, Emma L. Schymanski
Summary: The NORMAN Suspect List Exchange (NORMAN-SLE) is a global chemical information resource that hosts valuable suspect screening lists for the environmental community. It contains 99 separate lists from over 70 contributors, totaling over 100,000 unique substances. The NORMAN-SLE allows integration with other major chemical resources, fostering the exchange of information and supporting the paradigm shift to a one substance, one assessment approach.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Engineering, Environmental
Frank Menger, Gustaf Bostrom, Ove Jonsson, Lutz Ahrens, Karin Wiberg, Jenny Kreuger, Pablo Gago-Ferrero
Summary: This study developed a novel suspect screening approach to explore the presence of pesticides and their transformation products in the environment, successfully confirming multiple pesticide TPs. Integration of national monitoring data increased the number of prioritized compounds, and the presence of some TPs highlighted concerns related to environmental impacts.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Stephanie Chaousis, Frederic D. L. Leusch, Colin J. Limpus, Amanda Nouwens, Liesbeth J. Weijs, Antonia Weltmeyer, Adrian Covaci, Jason P. van de Merwe
Summary: All seven species of sea turtle are facing increasing pressures from human activities that are impacting their health. Changes in blood proteins can indicate adverse health outcomes. This study examines the protein abundance in sea turtle plasma, compares protein expression between different populations, and investigates markers of contaminant exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemical Research Methods
Siebe Lievens, Evelynn Vervoort, Giulia Poma, Adrian Covaci, Mik Van Der Borght
Summary: Concerns about microplastics in the environment have grown, leading scientists to conduct thorough studies. A cryogenic grinding and wet-sieving method was developed to efficiently produce and fractionate microplastics. With this method, polyvinyl chloride (PVC) microplastics could be produced with specific particle sizes and easily separated into different size ranges. The method has the potential to be applied to other types of plastics as well.
METHODS AND PROTOCOLS
(2023)
Article
Chemistry, Analytical
Chien-chia Chen, Karabi Mondal, Philippe Vervliet, Adrian Covaci, Evan P. O'Brien, Karl J. Rockne, James L. Drummond, Luke Hanley
Summary: Compound identification by database searching is commonly used in mass spectrometric data analysis. Machine learning was applied to statistically evaluate the identification results generated by software. Logistic regression was used to assign identification probabilities for each compound, providing more confidence in identification beyond database matching.
ANALYTICAL CHEMISTRY
(2023)
Article
Toxicology
Elias Iturrospe, Rani Robeyns, Katyeny Manuela da Silva, Maria van de Lavoir, Joost Boeckmans, Tamara Vanhaecke, Alexander L. N. van Nuijs, Adrian Covaci
Summary: Despite being common, alcoholic liver disease remains poorly understood, especially in its early stages. In this study, alcoholic steatohepatitis was simulated in vitro to investigate the metabolic alterations and identify affected pathways. The researchers discovered key findings, such as the influence of TNF-alpha on hepatic triglycerides and the detection of FAHFA-containing triglycerides in human hepatocytes, which may play an important role in the progression of alcoholic steatohepatitis. Additionally, ethoxylated phosphorylcholine was identified as a potential new biomarker of ethanol exposure.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Shanshan Yin, Thomas J. McGrath, Adam Cseresznye, Jasper Bombeke, Giulia Poma, Adrian Covaci
Summary: Chlorinated paraffins (CPs) are a major environmental concern and it is essential to have an effective tool for monitoring personal exposure to CPs. In this study, silicone wristbands (SWBs) were used as a personal passive sampler, and results showed that micro-environments were key contributors to dermal exposure to CPs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Analytical
Katyeny Manuela da Silva, Michele Woelk, Palina Nepachalovich, Elias Iturrospe, Adrian Covaci, Alexander L. N. van Nuijs, Maria Fedorova
Summary: Epilipids, a subset of the lipidome, play a crucial role in regulating redox lipid metabolism and influencing cell fate decisions. Ion mobility spectrometry (IMS) combined with liquid chromatography-high-resolution mass spectrometry (LC-HRMS) can improve the peak capacity and separation ability for the analysis of oxidized complex lipids. This study demonstrates the advantages and limitations of implementing IMS in LC-HRMS workflows and provides insights into the annotation of oxidized complex lipids.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Lidia Belova, Giulia Poma, Maarten Roggeman, Yunsun Jeong, Da-Hye Kim, Patrick Berghmans, Jan Peters, Amina Salamova, Alexander L. N. van Nuijs, Adrian Covaci
Summary: Quaternary ammonium compounds (QACs) in European indoor dust were identified, characterized, and semi-quantified using ion-mobility high-resolution mass spectrometry. Targeted QACs (21) and suspect QACs (17) were detected with high detection frequencies. The concentrations of individual QACs were estimated and daily intakes for adults and toddlers were calculated. This study provides important insights into the potential human exposure to QACs.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Thomas J. McGrath, Giulia Poma, Sebastien Hutinet, Yukiko Fujii, Robin E. Dodson, Boris Johnson-Restrepo, Dudsadee Muenhor, Gaud Dervilly, Ronan Cariou, Adrian Covaci
Summary: In this study, dust samples from Japan, Australia, Colombia, and Thailand were analyzed for different chain lengths of chlorinated paraffins. The results showed that chlorinated paraffins were detected in all samples, with the highest concentrations found in samples from Colombia and Thailand. Based on current toxicological data, it was determined that short-chain and medium-chain chlorinated paraffins in indoor dust do not pose a health risk through ingestion.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Elisabeth Hansen, Jiachen Sun, Bjorn Helander, Jan Ove Bustnes, Igor Eulaers, Veerle L. B. Jaspers, Adrian Covaci, Marcel Eens, Sophie Bourgeon
Summary: English Summary: Exposure to persistent organic pollutants (POPs), such as organochlorines (OCs) and polybrominated diphenyl ethers (PBDEs), can have adverse health effects on wildlife. White-tailed eagles in the Baltic ecosystem have suffered population declines due to severe exposure to DDT and PCB. In this study, feathers from breeding WTE pairs were analyzed to investigate the annual variations in feather corticosterone (fCORT), POPs, and dietary proxies. The results did not support fCORT as a relevant biomarker of contaminant-mediated effects in WTEs, but fCORT can be used as a non-destructive assessment of long-term stress physiology in wild raptors.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Paulien Cleys, Lucas Panneel, Jasper Bombeke, Catalina Dumitrascu, Govindan Malarvannan, Giulia Poma, Antonius Mulder, Philippe G. Jorens, Adrian Covaci
Summary: This study reports metabolites of phthalate and alternative plasticizers in neonatal hair samples as biomarkers for exposure to these plasticizers. Results showed that hair sampled from premature neonates after a NICU stay contained significantly higher metabolite concentrations of both phthalates and alternative plasticizers compared to healthy control neonates. Prolonged NICU exposure to respiratory support devices and gastric tubes was correlated with increased concentrations in hair samples.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemical Research Methods
Soledad Gonzalez-Rubio, Noelia Caballero-Casero, Ana Ballesteros-Gomez, Dario Cuervo, Gloria Munoz, Soledad Rubio
Summary: The study explored the use of supramolecular solvents (SUPRAS) for comprehensive liquid-liquid microextraction (LLME) in multiclass screening methods. The SUPRAS showed efficient extraction and interference removal of prohibited substances in sports, with high recoveries and low matrix effects. This research validates LLME based on SUPRAS as an efficient, economical, and simple sample treatment for multiclass screening methods.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Environmental Sciences
Laura Rodriguez Martin, Liese Gilles, Emilie Helte, Agneta Akesson, Jonas Tagt, Adrian Covaci, Amrit K. Sakhi, An Van Nieuwenhuyse, Andromachi Katsonouri, Anna-Maria Andersson, Arno C. Gutleb, Beata Janasik, Brice Appenzeller, Catherine Gabriel, Cathrine Thomsen, Darja Mazej, Denis Sarigiannis, Elena Anastasi, Fabio Barbone, Hanna Tolonen, Hanne Frederiksen, Jana Klanova, Jani Koponen, Janja Snoj Tratnik, Kim Pack, Koppen Gudrun, Kristin Olafsdottir, Lisbeth E. Knudsen, Loic Rambaud, Loreta Strumylaite, Lubica Palkovicova Murinova, Lucia Fabelova, Margaux Riou, Marika Berglund, Mate Szabados, Medea Imboden, Michelle Laeremans, Milada Estokova, Natasa Janev Holcer, Nicole Probst-Hensch, Nicole Vodrazkova, Nina Vogel, Pavel Piler, Phillipp Schmidt, Rosa Lange, Sonia Namorado, Szilvia Kozepesy, Tamas Szigeti, Thorhallur I. Halldorsson, Till Weber, Tina Kold Jensen, Valentina Rosolen, Vladimira Puklova, Wojciech Wasowicz, Ovnair Sepai, Lorraine Stewart, Marike Kolossa-Gehring, Marta Esteban-Lopez, Argelia Castano, Jos Bessems, Greet Schoeters, Eva Govarts
Summary: This study evaluated the exposure levels of children and women in Europe over time. The results showed that exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. These findings are important for policy efficacy monitoring and highlight the role of HBM in supporting policies.
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.
Article
Engineering, Environmental
Anran Cai, Sylvie Remy, Virissa Lenters, Bianca Cox, Greet Schoeters, Adrian Covaci, Roel Vermeulen, Lutzen Portengen
Summary: Childhood exposure to endocrine-disrupting chemicals (EDCs) may affect metabolic outcomes. Our study found associations between certain chemicals and body mass index, abdominal obesity, total cholesterol, and triglycerides. Further investigation is needed for sex-specific effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)