Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

(2017) M. Charles Liberman et al.   HEARING RESEARCH

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

(2017) Lukas D Landegger et al.   NATURE BIOTECHNOLOGY

Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk

(2017) Mark A. Crumling et al.   Frontiers in Cellular Neuroscience

Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing

(2017) Adrian Joseph et al.   Science Advances

Degeneration of stria vascularis in age-related hearing loss; a corrosion cast study in a mouse model

(2016) Mattia Carraro et al.   ACTA OTO-LARYNGOLOGICA

Biomimetic Hybrid Nanocontainers with Selective Permeability

(2016) Lea Messager et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)

(2016) Xiaorui Shi   HEARING RESEARCH

Toll-like receptor 4 modulates the cochlear immune response to acoustic injury

(2016) R R Vethanayagam et al.   Cell Death & Disease

Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure

(2016) Jun Suzuki et al.   Scientific Reports

A Non-canonical Pathway from Cochlea to Brain Signals Tissue-Damaging Noise

(2015) Emma N. Flores et al.   CURRENT BIOLOGY

Recent advances in local drug delivery to the inner ear

(2015) Naila El Kechai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid

(2015) A. N. Salt et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Cell-based neurotrophin treatment supports long-term auditory neuron survival in the deaf guinea pig

(2015) Lisa N. Gillespie et al.   JOURNAL OF CONTROLLED RELEASE

New treatment options for hearing loss

(2015) Ulrich Müller et al.   NATURE REVIEWS DRUG DISCOVERY

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

(2015) Ja-Won Koo et al.   Science Translational Medicine

Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation

(2015) Esperanza Bas et al.   Frontiers in Cellular Neuroscience

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

(2015) Kristina E. Froud et al.   Nature Communications

LRP-1-mediated intracellular antibody delivery to the Central Nervous System

(2015) Xiaohe Tian et al.   Scientific Reports

Noise alters guinea pig’s blood-labyrinth barrier ultrastructure and permeability along with a decrease of cochlear Claudin-5 and Occludin

(2014) Yong-Xiang Wu et al.   BMC NEUROSCIENCE

Differential Expression of Transcription Factors and Inflammation-, ROS-, and Cell Death-Related Genes in Organotypic Cultures in the Modiolus, the Organ of Corti and the Stria Vascularis of Newborn Rats

(2014) Johann Gross et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Novel aspects of encapsulation and delivery using polymersomes

(2014) Léa Messager et al.   CURRENT OPINION IN PHARMACOLOGY

Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow

(2014) Xiaorui Shi et al.   HEARING RESEARCH

Systemic Lipopolysaccharide Compromises the Blood-Labyrinth Barrier and Increases Entry of Serum Fluorescein into the Perilymph

(2014) Keiko Hirose et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Integrating the active process of hair cells with cochlear function

(2014) A. J. Hudspeth   NATURE REVIEWS NEUROSCIENCE

The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss

(2014) J. Chen et al.   NEUROSCIENCE

A brief history of hair cell regeneration research and speculations on the future

(2013) Edwin W. Rubel et al.   HEARING RESEARCH

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Hearing Preservation Surgery

(2013) Sarah Havenith et al.   OTOLOGY & NEUROTOLOGY

Fates of Murine Pluripotent Stem Cell-Derived Neural Progenitors following Transplantation into Mouse Cochleae

(2012) Koji Nishimura et al.   CELL TRANSPLANTATION

Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier

(2012) Damir Janigro   EPILEPSIA

Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

(2012) Ya Zhang et al.   International Journal of Nanomedicine

Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear

(2012) Elena V. Surovtseva et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Contractility in Type III Cochlear Fibrocytes Is Dependent on Non-muscle Myosin II and Intercellular Gap Junctional Coupling

(2012) John J. Kelly et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Endothelial Cell, Pericyte, and Perivascular Resident Macrophage-Type Melanocyte Interactions Regulate Cochlear Intrastrial Fluid–Blood Barrier Permeability

(2012) Lingling Neng et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

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(2012) Silvia Murillo-Cuesta et al.   MOLECULAR MEDICINE

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

(2012) Wei Chen et al.   NATURE

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

(2012) Omar Akil et al.   NEURON

Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea

(2012) Shi-Ming Yang et al.   PLoS One

Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier

(2012) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of human inner ear prosensory-like cells via epithelial-to-mesenchymal transition

(2012) Zhengqing Hu et al.   Regenerative Medicine

Drug Delivery to the Inner Ear: Strategies and Their Therapeutic Implications for Sensorineural Hearing Loss

(2012) Teresa Rivera et al.   Current Drug Delivery

Infection-Mediated Vasoactive Peptides Modulate Cochlear Uptake of Fluorescent Gentamicin

(2011) Ja-Won Koo et al.   AUDIOLOGY AND NEURO-OTOLOGY

Impaired stria vascularis integrity upon loss of E-cadherin in basal cells

(2011) Mark-Oliver Trowe et al.   DEVELOPMENTAL BIOLOGY

Expression of genes implicated in oxidative stress in the cochlea of newborn rats

(2011) Birgit Mazurek et al.   HEARING RESEARCH

Age-Related Primary Cochlear Neuronal Degeneration in Human Temporal Bones

(2011) Chadi A. Makary et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Na+/K+-ATPase α1 Identified as an Abundant Protein in the Blood-Labyrinth Barrier That Plays an Essential Role in the Barrier Integrity

(2011) Yue Yang et al.   PLoS One

Fibro-Vascular Coupling in the Control of Cochlear Blood Flow

(2011) Min Dai et al.   PLoS One

Acoustic Trauma Increases Cochlear and Hair Cell Uptake of Gentamicin

(2011) Hongzhe Li et al.   PLoS One

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Distribution of Dexamethasone and Preservation of Inner Ear Function following Intratympanic Delivery of a Gel-Based Formulation

(2010) Alec N. Salt et al.   AUDIOLOGY AND NEURO-OTOLOGY

Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells

(2010) Xiaorui Shi   CELL AND TISSUE RESEARCH

Competitive antagonism of fluorescent gentamicin uptake in the cochlea

(2010) Qi Wang et al.   HEARING RESEARCH

Volumetric In Vivo Imaging of Microvascular Perfusion Within the Intact Cochlea in Mice Using Ultra-High Sensitive Optical Microangiography

(2010) H M Subhash et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: Potential tool for drug delivery

(2010) Soumen Roy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The cell biology of hearing

(2010) Martin Schwander et al.   JOURNAL OF CELL BIOLOGY

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Expression of the proinflammatory cytokines in cochlear explant cultures: Influence of normoxia and hypoxia

(2010) Martin Khan et al.   NEUROSCIENCE LETTERS

Cubilin and Megalin Co-Localize in the Neonatal Inner Ear

(2009) Jacob Tauris et al.   AUDIOLOGY AND NEURO-OTOLOGY

Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament

(2009) Min Dai et al.   HEARING RESEARCH

Trafficking of Systemic Fluorescent Gentamicin into the Cochlea and Hair Cells

(2009) Qi Wang et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss

(2009) S. G. Kujawa et al.   JOURNAL OF NEUROSCIENCE

Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy

(2009) Stefan K. Plontke et al.   LARYNGOSCOPE

The blood–brain barrier and immune function and dysfunction

(2009) William A. Banks et al.   NEUROBIOLOGY OF DISEASE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

RAPID CLEARANCE OF METHYLPREDNISOLONE AFTER INTRATYMPANIC APPLICATION IN HUMANS. COMMENT ON: BIRD PA, BEGG EJ, ZHANG M, ET AL. INTRATYMPANIC VERSUS INTRAVENOUS DELIVERY OF METHYLPREDNISOLONE TO COCHLEAR PERILYMPH. OTOL NEUROTOL 2007;28:1124-30

(2009) Stefan K. Plontke et al.   OTOLOGY & NEUROTOLOGY

Dexamethasone Concentration Gradients Along Scala Tympani After Application to the Round Window Membrane

(2009) Stefan K. Plontke et al.   OTOLOGY & NEUROTOLOGY

Human Fetal Auditory Stem Cells Can Be Expanded In Vitro and Differentiate Into Functional Auditory Neurons and Hair Cell-Like Cells

(2009) Wei Chen et al.   STEM CELLS

Inner ear drug delivery for auditory applications

(2008) Erin E. Leary Swan et al.   ADVANCED DRUG DELIVERY REVIEWS

Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline

(2008) Kevin K. Ohlemiller et al.   HEARING RESEARCH

The Cochlear Pericytes

(2008) Xiaorui Shi et al.   MICROCIRCULATION

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer

(2008) Samuel P. Gubbels et al.   NATURE

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear

(2008) F. Nin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA