Innate immunity and interferons in the pathogenesis of Sjögren’s syndrome

CD40 as a therapeutic target in Sjögren’s syndrome

(2018) Kerry Jobling et al.   Expert Review of Clinical Immunology

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis

(2018) Iris L.A. Bodewes et al.   JOURNAL OF AUTOIMMUNITY

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

(2018) Gina A. Montealegre Sanchez et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferon in rheumatic diseases

(2018) Theresa L. Wampler Muskardin et al.   Nature Reviews Rheumatology

Systemic interferon type I and type II signatures in primary Sjögren’s syndrome reveal differences in biological disease activity

(2018) Iris L A Bodewes et al.   RHEUMATOLOGY

Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review

(2017) Kun Chen et al.   JOURNAL OF AUTOIMMUNITY

Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options

(2017) Romy Strauß et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Patients with Primary Sjögren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

(2017) R. Davies et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome

(2017) Simon J. Bowman et al.   Arthritis & Rheumatology

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

(2017) Richard Furie et al.   Arthritis & Rheumatology

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Contrasting expression pattern of RNA-sensing receptors TLR7, RIG-I and MDA5 in interferon-positive and interferon-negative patients with primary Sjögren's syndrome

(2016) Naomi I Maria et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes

(2016) Juliana Imgenberg-Kreuz et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome

(2016) E. Apostolou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores

(2016) Nikolaos I. Vlachogiannis et al.   CLINICAL IMMUNOLOGY

Infections as risk factor for autoimmune diseases – A nationwide study

(2016) Philip Rising Nielsen et al.   JOURNAL OF AUTOIMMUNITY

Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study

(2016) Chang Ho Yoon et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Safety, pharmacokinetics, and pharmacodynamics of RSLV-132, an RNase-Fc fusion protein in systemic lupus erythematosus: a randomized, double-blind, placebo-controlled study

(2016) D J Burge et al.   LUPUS

Treatment of primary Sjögren syndrome

(2016) Alain Saraux et al.   Nature Reviews Rheumatology

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

(2016) Julie Ducreux et al.   RHEUMATOLOGY

Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome

(2016) Naomi I. Maria et al.   Arthritis & Rheumatology

Toll-like receptors: potential targets for lupus treatment

(2015) Yan-wei Wu et al.   ACTA PHARMACOLOGICA SINICA

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

Update on the immunobiology of Sjögrenʼs syndrome

(2015) Aurélie Ambrosi et al.   CURRENT OPINION IN RHEUMATOLOGY

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

(2015) A. Pellerin et al.   EMBO Molecular Medicine

Type I and II interferon signatures in Sjogren's syndrome pathogenesis: Contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis

(2015) Adrianos Nezos et al.   JOURNAL OF AUTOIMMUNITY

The Expression of BAFF Is Controlled by IRF Transcription Factors

(2015) Maria Sjöstrand et al.   JOURNAL OF IMMUNOLOGY

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

(2015) T. Hung et al.   SCIENCE

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren’s syndrome: results of the BELISS study

(2015) Raphaèle Seror et al.   ARTHRITIS RESEARCH & THERAPY

Molecular Subsetting of Interferon Pathways in Sjögren's Syndrome

(2015) John C. Hall et al.   Arthritis & Rheumatology

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome

(2015) Katherine James et al.   PLoS One

Treatment of Primary Sjögren Syndrome With Rituximab

(2014) Valérie Devauchelle-Pensec et al.   ANNALS OF INTERNAL MEDICINE

What is the future of targeted therapy in rheumatology: biologics or small molecules?

(2014) Attila Mócsai et al.   BMC Medicine

Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome

(2014) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interferon Receptor Signaling in Malignancy: A Network of Cellular Pathways Defining Biological Outcomes

(2014) E. N. Fish et al.   MOLECULAR CANCER RESEARCH

Vaccination of patients with autoimmune inflammatory rheumatic diseases

(2014) Johanna Westra et al.   Nature Reviews Rheumatology

Comparison of Whole Blood RNA Preservation Tubes and Novel Generation RNA Extraction Kits for Analysis of mRNA and MiRNA Profiles

(2014) Madlen Häntzsch et al.   PLoS One

Belimumab after rituximab as maintenance therapy in lupus nephritis

(2014) T. Kraaij et al.   RHEUMATOLOGY

Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study

(2013) Xavier Mariette et al.   ANNALS OF THE RHEUMATIC DISEASES

MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome

(2013) Naomi I Maria et al.   ANNALS OF THE RHEUMATIC DISEASES

Rituximab Therapy for Primary Sjögren's Syndrome: An Open-Label Clinical Trial and Mechanistic Analysis

(2013) E. William St.Clair et al.   ARTHRITIS AND RHEUMATISM

Sifalimumab, a Human Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study

(2013) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors

(2013) M. Sjostrand et al.   JOURNAL OF IMMUNOLOGY

NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome

(2013) S. Rusakiewicz et al.   Science Translational Medicine

Rare Variants in theTREX1Gene and Susceptibility to Autoimmune Diseases

(2013) Nadia Barizzone et al.   Biomed Research International

Human Plasmacytoid Dendritic Cells: From Molecules to Intercellular Communication Network

(2013) Till S. M. Manuel Mathan et al.   Frontiers in Immunology

Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

(2012) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: A possible new treatment?

(2012) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent

(2012) Philippa Hillyer et al.   IMMUNOLOGY AND CELL BIOLOGY

Interferon-Induced Depression in Chronic Hepatitis C

(2012) Marc Udina et al.   JOURNAL OF CLINICAL PSYCHIATRY

BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands

(2012) L. Quartuccio et al.   RHEUMATOLOGY

Efficacy of rituximab in primary Sjögren's syndrome with peripheral nervous system involvement: results from the AIR registry

(2011) A Mekinian et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface

(2011) Alexander Espinosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Systems Biology of Interferon Responses

(2011) Paul Hertzog et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases

(2010) S. van Assen et al.   ANNALS OF THE RHEUMATIC DISEASES

Effectiveness of rituximab treatment in primary Sjögren's syndrome: A randomized, double-blind, placebo-controlled trial

(2010) J. M. Meijer et al.   ARTHRITIS AND RHEUMATISM

Decrease of blood dendritic cells and increase of tissue-infiltrating dendritic cells are involved in the induction of Sjögren's syndrome but not in the maintenance

(2010) Y. Ozaki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling

(2010) N Gestermann et al.   GENES AND IMMUNITY

Interferon-Lambda: A New Addition to an Old Family

(2010) Raymond P. Donnelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Systemic lupus erythematosus and Sjögren's syndrome induced in a case by interferon-α used for the treatment of hepatitis C

(2010) S. Onishi et al.   LUPUS

Effects of hydroxychloroquine on salivary flow rates and oral complaints of Sjögren patients: a prospective sample study

(2010) Hulya Çankaya et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus

(2010) P. Duffau et al.   Science Translational Medicine

The CGGGG insertion/deletion polymorphism of theIRF5promoter is a strong risk factor for primary Sjögren's syndrome

(2009) Corinne Miceli-Richard et al.   ARTHRITIS AND RHEUMATISM

Peripheral blood gene expression profiling in Sjögren's syndrome

(2009) E S Emamian et al.   GENES AND IMMUNITY

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

(2009) Maria I. Christodoulou et al.   JOURNAL OF AUTOIMMUNITY

Adjuvant Therapy With Pegylated Interferon Alfa-2b Versus Observation in Resected Stage III Melanoma: A Phase III Randomized Controlled Trial of Health-Related Quality of Life and Symptoms by the European Organisation for Research and Treatment of Cancer Melanoma Group

(2009) Andrew Bottomley et al.   JOURNAL OF CLINICAL ONCOLOGY

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infections and autoimmunity: the multifaceted relationship

(2009) P. Sfriso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

(2009) Sherine E Gabriel et al.   ARTHRITIS RESEARCH & THERAPY

Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study

(2008) S Dass et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Prevalence, severity, and predictors of fatigue in subjects with primary Sjögren's syndrome

(2008) Barbara Segal et al.   ARTHRITIS AND RHEUMATISM

Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history

(2008) P FITZGERALDBOCARSLY et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Systemic increase in type I interferon activity in Sjögren's syndrome: A putative role for plasmacytoid dendritic cells

(2008) Manon E. Wildenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

(2008) G Nordmark et al.   GENES AND IMMUNITY

Variant form of STAT4 is associated with primary Sjögren's syndrome

(2008) B D Korman et al.   GENES AND IMMUNITY

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE