GSAP modulates γ-secretase specificity by inducing conformational change in PS1

Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease

(2017) Sylvia E. Perez et al.   Neurodegenerative Diseases

GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome

(2015) Jin Chu et al.   ANNALS OF NEUROLOGY

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Structural basis of human γ-secretase assembly

(2015) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common GSAP promoter variant contributes to Alzheimer's disease liability

(2014) Min Zhu et al.   NEUROBIOLOGY OF AGING

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

Purification and Characterization of the Human γ-Secretase Activating Protein

(2012) Catherine L. Deatherage et al.   BIOCHEMISTRY

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

(2012) De-Ming Chau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation

(2012) Ishrut Hussain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

An exo-cell assay for examining real-time γ-secretase activity and inhibition

(2009) Christopher C Shelton et al.   Molecular Neurodegeneration

Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2 γ-Secretase Complexes

(2008) Lisa Placanica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch: from neural development to neurological disorders

(2008) Justin D. Lathia et al.   JOURNAL OF NEUROCHEMISTRY