SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production

(2018) Yukitaka Ito et al.   CELL

On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation

(2018) Giulia Pagani et al.   Scientific Reports

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

Hyper-O-GlcNAcylation activates nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling through interplay with phosphorylation and acetylation

(2017) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex

(2017) Meraj H. Khan et al.   JOURNAL OF CELL SCIENCE

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

Linear ubiquitin chains: enzymes, mechanisms and biology

(2017) Katrin Rittinger et al.   Open Biology

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

(2016) Florian Beck et al.   BLOOD

NF-κB signaling pathway as target for antiplatelet activity

(2016) Eduardo Fuentes et al.   BLOOD REVIEWS

The comings and goings of MHC class I molecules herald a new dawn in cross-presentation

(2016) J. Magarian Blander   IMMUNOLOGICAL REVIEWS

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and ThrombosisSignificance

(2015) Nilaksh Gupta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of integrins in platelets

(2015) Joel S. Bennett   BIOPOLYMERS

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN

(2015) Paul R. Elliott et al.   FEBS Journal

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system

(2015) Katsuhiro Sasaki et al.   IMMUNOLOGICAL REVIEWS

Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles

(2015) Katie L. Lannan et al.   Frontiers in Immunology

MALT1-Ubiquitination Triggers Non-Genomic NF-κB/IKK Signaling upon Platelet Activation

(2015) Zubair A. Karim et al.   PLoS One

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

(2015) Nicola De Franceschi et al.   PLoS One

Integrin Cytoplasmic Tail Interactions

(2014) Elizabeth M. Morse et al.   BIOCHEMISTRY

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

(2014) Chaker Aloui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

(2014) Christopher S. Potter et al.   PLoS One

I B kinase phosphorylation of SNAP-23 controls platelet secretion

(2013) Z. A. Karim et al.   BLOOD

Platelets as Cellular Effectors of Inflammation in Vascular Diseases

(2013) Matthew T. Rondina et al.   CIRCULATION RESEARCH

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

(2013) Jeroen Pouwels et al.   Cell Reports

Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade

(2012) Wan J. Lu et al.   BIOCHEMICAL PHARMACOLOGY

Platelets Present Antigen in the Context of MHC Class I

(2012) L. M. Chapman et al.   JOURNAL OF IMMUNOLOGY

Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression

(2012) Holger Buss et al.   PLoS One

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Structure of the Integrin αIIb Transmembrane Segment

(2008) Tong-Lay Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Citrobacter rodentium-induced NF-κB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation

(2006) Yu Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY