Transitions to catalytically inactive conformations in EGFR kinase

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation

(2012) Silvia Lovera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation

(2012) S. Wan et al.   MOLECULAR CANCER THERAPEUTICS

Biomolecular dynamics: order–disorder transitions and energy landscapes

(2012) Paul C Whitford et al.   REPORTS ON PROGRESS IN PHYSICS

Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

(2012) Ketan S. Gajiwala et al.   STRUCTURE

EGFR Signaling and Drug Discovery

(2010) Georg Lurje et al.   ONCOLOGY

Comparison of Three Perturbation Molecular Dynamics Methods for Modeling Conformational Transitions

(2009) He Huang et al.   Journal of Chemical Theory and Computation

Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories

(2009) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced global transitions in the catalytic domain of protein kinase A

(2009) C. Hyeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of ADP from the catalytic subunit of protein kinase A: A molecular dynamics simulation study

(2004) Benzhuo Lu et al.   PROTEIN SCIENCE