Article
Rheumatology
Avishai M. Tsur, Abdulla Watad, Omer Gendelman, Daniel Nissan, Arnon D. Cohen, Howard Amital
Summary: The study found a positive association between FMF and asthma through a cross-sectional study. Further research is needed to validate and explore possible explanations for this association. These findings challenge previous studies that suggested FMF as a protective factor against asthma.
Review
Biochemistry & Molecular Biology
Maddalena Lancieri, Marta Bustaffa, Serena Palmeri, Ignazia Prigione, Federica Penco, Riccardo Papa, Stefano Volpi, Roberta Caorsi, Marco Gattorno
Summary: This study provides an updated overview on the main aspects of pathophysiology, genetics, diagnosis, and treatment resistance of Familial Mediterranean Fever (FMF), a prototypal autoinflammatory disease. It also emphasizes the importance of FMF in understanding the functioning of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Seza Ozen
Summary: Recent studies have revealed new insights into the pathogenesis of familial Mediterranean fever, including genetic mutations conferring resistance to ancient microbial pathogens and recommendations for genetic analysis of FMF. We now have recommendations for assessing genetic analysis of the MEFV gene and how to reliably classify a patient as FMF.
CURRENT OPINION IN RHEUMATOLOGY
(2021)
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Review
Rheumatology
Cengiz Korkmaz, Dondu Uskudar Cansu, Sibel Canbaz Kabay
Summary: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by fever and serositis attacks caused by mutations in the MEditerranean FeVer (MEFV) gene encoding the pyrin gene. FMF patients are more likely to develop inflammatory diseases such as Behcet's disease, psoriasis, and vasculitis, as well as multiple sclerosis. The coexistence of FMF and demyelinating disorders in multiple family members is rare, with only a few reported cases.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Immunology
Maeva Veyssiere, Sara Sadat Aghamiri, Arturo Hernandez Cervantes, Thomas Henry, Vassili Soumelis
Summary: This study aimed to provide a computational model capturing the mechanistic details of biological pathways involved in FMF physiopathology and studying the dynamics of the patient's immune cells. By building a molecular map and a mathematical model of FMF, the researchers were able to identify key players in the disease inflammation phenotype. The results of the study showed that NF-kappa B and JAK1/TYK2 play critical roles in modulating the inflammatory response.
CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Selen Duygu Arik, Gulsah Kavrul Kayaalp, Vafa Guliyeva, Fatma Gul Demirkan, Ayse Tanatar, Ozlem Akgun, Sengul Caglayan, Kadir Ulu, Taner Coskuner, Serife Gul Karadag, Betul Sozeri, Nuray Aktay Ayaz
Summary: This study compared the characteristics of FMF patients with and without fever during their attacks and highlighted the different clinical presentations of FMF in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Zehra Serap Arici, Micol Romano, David Piskin, Ferhat Guzel, Sezgin Sahin, Roberta A. Berard, Mahmut Yilmaz, Erkan Demirkaya
Summary: This study aimed to compare the clinical phenotype of patients with FMF-related AA amyloidosis based on age of FMF diagnosis and E148Q genotype. The most common clinical manifestations were fever, abdominal pain, and arthritis. The study found M694V and E148Q to be the most common genetic mutations, with higher mortality rate among patients with homozygous M694V genotype and the need for close monitoring of patients with homozygous E148Q genotype. The relationship between E148Q and AA amyloidosis warrants further confirmation in other ethnicities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Emire Seyahi, Serdal Ugurlu, Shirkhan Amikishiyev, Ahmet Gul
Summary: Behget disease (BD) and familial Mediterranean fever (FMF) are two inflammatory disorders that have common features and may occur in the same individual more commonly than expected. The pathogenic MEFV gene variants, especially p.Met694Val, have been shown to increase the risk for BD in regions where both FMF and BD are prevalent. Further exploration is needed to determine the association between these variants and specific disease subtypes, as well as their potential role in treatment planning. This review provides an overview of the plausible association between FMF and BD and the role of MEFV variants in the pathogenesis of BD.
CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Serap Kirkiz, Zuhre Kaya, Sevim Gonen, Munci Yagci, Ulker Kocak
Summary: This study investigated the simultaneous occurrences of Familial Mediterranean Fever (FMF) in patients with haemophilia, identifying 8 out of 30 severe haemophilic patients with FMF. The study found that FMF patients had fewer target joints and a positive family history, indicating the importance of screening for FMF in haemophilia patients with arthritis and a family history of FMF in Mediterranean countries.
Article
Pediatrics
Esra Nagehan Akyol Onder, Kudret Ebru Ozcan, Feride Iffet Sahin, Kaan Savas Gulleroglu, Esra Baskin
Summary: This study compared the application of pediatric criteria, Tel-Hashomer criteria, and 2019 Eurofever/PRINTO classification criteria in the diagnosis of FMF. The study found that the sensitivity and specificity of pediatric criteria were comparable to Tel-Hashomer criteria, and the Eurofever/PRINTO classification criteria had high sensitivity and specificity.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Ali Motahharynia, Ghazaal Alavi Tabatabaei, Reza Sarrafi, Saba Naghavi, Iman Adibi
Summary: Familial Mediterranean fever (FMF) is a rare autoinflammatory disorder characterized by recurrent fever and polyserositis. The relationship between FMF and demyelinating disorders has been debated, but this report presents the first case of transverse myelitis following FMF attacks in which colchicine and rituximab treatments were used to alleviate symptoms. This suggests that rituximab could be a potential therapeutic option for colchicine-resistant FMF and FMF-related demyelinating conditions.
NEUROLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Bahri Oztas, Hatice Eren, Ali Yagiz Ayla, Ali Koc, Kemal Erol, Adile Irfan, Erkan Caglar, Serdal Ugurlu
Summary: This study investigated the relationship between portal hypertension and familial Mediterranean fever (FMF). The results showed that FMF patients had significantly lower peak portal blood flow velocity compared to the control group, indicating the presence of portal hypertension. However, the differences in other findings related to portal hypertension were not significant.
Article
Rheumatology
Sevtap Acer Kasman, Mehmet Tuncay Duruoz
Summary: This study evaluated the frequency and manifestations of spondyloarthritis (SpA) in patients with familial Mediterranean fever (FMF), as well as the impact of SpA on FMF and the associations of non-episodic findings with FMF features. The results showed that a significant number of FMF patients also had SpA, indicating that SpA and its shared manifestations with FMF may have an impact on FMF.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Fadi Kharouf, Yuval Ishay, Ariel Kenig, Menachem Bitan, Eldad Ben-Chetrit
Summary: The study found no significant difference in the odds of hospitalization for COVID-19 between FMF patients and the non-FMF population, and similar disease severity and therapeutic approach in FMF COVID-19 inpatients and matched non-FMF COVID-19 inpatients.
Letter
Medicine, General & Internal
Sebahattin Yurdakul, Gizem Ayan, Yesim Ozguler, Gulen Hatemi, Serdal Ugurlu, Emire Seyahi, Hasan Yazici
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Immunology
Huri Ozdogan, Serdal Ugurlu
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2017)
Article
Genetics & Heredity
Serdal Ugurlu, Aysa Hacioglu, Yasaman Adibnia, Vedat Hamuryudan, Huri Ozdogan
ORPHANET JOURNAL OF RARE DISEASES
(2017)
Article
Rheumatology
Taryn Youngstein, Patrycja Hoffmann, Ahmet Gul, Thirusha Lane, Rene Williams, Dorota M. Rowczenio, Huri Ozdogan, Serdal Ugurlu, John Ryan, Len Harty, Sean Riminton, Alex P. Headley, Joachim Roesler, Norbert Blank, Jasmin B. Kuemmerle-Deschner, Anna Simon, Adrian S. Woolf, Philip N. Hawkins, Helen J. Lachmann
Article
Rheumatology
Mert Oztas, Serdal Ugurlu, Ovgu Aydin
RHEUMATOLOGY INTERNATIONAL
(2017)
Article
Rheumatology
Sezgin Sahin, Amra Adrovic, Kenan Barut, Serdal Ugurlu, Eda Tahir Turanli, Huri Ozdogan, Ozgur Kasapcopur
RHEUMATOLOGY INTERNATIONAL
(2018)
Letter
Rheumatology
Ilker Karacan, Serdal Ugurlu, Sezgin Sahin, Elif Everest, Ozgur Kasapcopur, Aslihan Tolun, Huri Ozdogan, Eda Tahir Turanli
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Rheumatology
Ilker Karacan, Ayse Balamir, Serdal Ugurlu, Asli Kirectepe Aydin, Elif Everest, Seyit Zor, Merve Ozkilinc Onen, Selcuk Dasdemir, Ozan Ozkaya, Betul Sozeri, Abdurrahman Tufan, Deniz Gezgin Yildirim, Selcuk Yuksel, Nuray Aktay Ayaz, Rukiye Eker Omeroglu, Kubra Ozturk, Mustafa Cakan, Oguz Soylemezoglu, Sezgin Sahin, Kenan Barut, Amra Adrovic, Emire Seyahi, Huri Ozdogan, Ozgur Kasapcopur, Eda Tahir Turanli
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Rheumatology
M. Erdogan, S. Ugurlu, H. Ozdogan, E. Seyahi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)
Review
Rheumatology
Gizem Ayan, Sinem Nihal Esatoglu, Gulen Hatemi, Serdal Ugurlu, Emire Seyahi, Melike Melikoglu, Izzet Fresko, Huri Ozdogan, Sebahattin Yurdakul, Vedat Hamuryudan
RHEUMATOLOGY INTERNATIONAL
(2018)
Article
Rheumatology
I. Karacan, S. Ugurlu, A. Tolun, E. Tahir Turanli, H. Ozdogan
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2017)
Article
Medicine, Research & Experimental
Abdulhalim Senyigit, Omur Tabak, Timur Orbanoglu, Aytac Karadag, Serdal Ugurlu, Hafize Uzun, Dihlar Konukoglu
CLINICAL AND INVESTIGATIVE MEDICINE
(2017)
Article
Clinical Neurology
Ugur Uygunoglu, Burcu Zeydan, Yesim Ozguler, Serdal Ugurlu, Emire Seyahi, Naci Kocer, Civan Islak, Kejal Kantarci, Sabahattin Saip, Aksel Siva, Orhun H. Kantarci
ANNALS OF NEUROLOGY
(2017)
Article
Rheumatology
S. N. Esatoglu, E. Seyahi, S. Ugurlu, F. Gulsen, C. Akman, M. Cantasdemir, F. Numan, H. Tuzun, M. Melikoglu, H. Yazici, V. Hamuryudan
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2016)