Article
Multidisciplinary Sciences
Tim Kuemmel, Bjoern van Marwick, Miriam Rittel, Carina Ramallo Guevara, Felix Wuehler, Tobias Teumer, Bjoern Waengler, Carsten Hopf, Matthias Raedle
Summary: Frozen section analysis is a commonly used method for tissue examination, especially in tumor detection. This research introduces a fast spectroscopic measurement device and workflow that significantly improves the speed and accuracy of frozen tissue section analysis, allowing for rapid visualization of tissue structures and tumor margins based on their lipid and protein molecular vibrations.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Dekang Chen, Stephen D. March, Andrew H. Jones, Yang Shen, Adam A. Dadey, Keye Sun, J. Andrew McArthur, Alec M. Skipper, Xingjun Xue, Bingtian Guo, Junwu Bai, Seth R. Bank, Joe C. Campbell
Summary: The development of mid-wave infrared photonics has led to a demand for high-performance photodetectors operating in this range. However, the high dark current in narrow-bandgap materials limits the signal-to-noise ratio of mid-wave infrared detection. To tackle this challenge, an avalanche photodiode design using photon-trapping structures is introduced, which enhances quantum efficiency and reduces dark current. The achieved results show significantly improved performance compared to previous photodiodes, with high quantum efficiency, low dark current, increased bandwidth, and gain-bandwidth product.
Article
Chemistry, Analytical
Yeran Bai, Zhongyue Guo, Fatima C. Pereira, Michael Wagner, Ji-Xin Cheng
Summary: A mid-infrared photothermal-fluorescence in situ hybridization (MIP-FISH) platform is developed for simultaneous identification and metabolic analysis of microbes with single-cell resolution and high throughput. By improving MIP imaging, isotopically labeled compounds incorporated into proteins of individual bacterial cells can be sensitively detected, while FISH labeling with rRNA-targeted probes enables the identification of the analyzed cells. In proof-of-concept experiments, MIP-FISH successfully discriminates and identifies labeled bacterial cells within a complex human gut microbiome sample based on the clear spectral red shift in the protein amide I region caused by incorporation of 13C atoms from 13C-labeled glucose. This study opens up new opportunities for single-cell structure-function analyses in microbiology.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tanurup Das, Annapoorni Ammal, Abhimanyu Harshey, Vindresh Mishra, Ankit Srivastava
Summary: Semen is a critical body fluid in sexual assaults, and vibrational spectroscopy has emerged as a valuable tool for its analysis, but practical limitations still exist. Research has focused on identifying, discriminating, and estimating timing since deposition of semen.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Chencheng Shen, Xianglong Cai, Tiancheng Zheng, Yuxi Jia, Dong Liu, Jinbo Liu, Jingwei Guo
Summary: This study demonstrated the application of mid-infrared lasers in free space, generating stimulated Raman scattering lasers using mixed gases of hydrogen and deuterium to reduce the threshold of mid-IR laser generation and achieve high power output. Multiple spectral mid-IR Raman lasers were also generated, showcasing the potential of this convenient method.
APPLIED SCIENCES-BASEL
(2021)
Article
Computer Science, Artificial Intelligence
Jyothi Johnson, R. Chitra, A. M. Anusha Bamini
Summary: This study proposes a bi-traits-based offender identification method using a Cross Entropy-based Deep Remainder Neural Network (CEDRNN) to analyze the evidence, traits, and clues collected from crime scenes. The experimental results show that this method achieves the highest accuracy and effectively identifies the offender without mis-prediction.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Materials Science, Ceramics
X. Y. Zhang, F. Yang, S. K. Zhu, X. Chen, K. M. Qin, T. S. Wang, H. B. Peng
Summary: Borosilicate glass is a promising material for immobilization of high-level radioactive waste, and its leaching behavior is crucial for the safety of HLW deep geological disposal.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Food Science & Technology
Yi Xu, Anastasios Koidis, Xingguo Tian, Sai Xu, Xiaoyan Xu, Xiaoqun Wei, Aimin Jiang, Hongtao Lei
Summary: In this study, a Bayesian-based decision fusion technique was developed to identify codfish using near infrared and Raman spectroscopy. The Bayesian model showed significantly better classification performance compared to other spectroscopic methods and data fusion methods.
Article
Chemistry, Analytical
Haolan Yang, Liangying Bao, Yifei Liu, Shuting Luo, Fengyan Zhao, Guangyu Chen, Fang Liu
Summary: This study proposes a multi-dimensional analysis method utilizing Fourier-transform mid-infrared spectroscopy and diode-array near-infrared spectroscopy in combination with chemometric techniques, successfully identifying and quantifying salt-adulterated honeysuckle. Through the PLS-DA model, the authentication of different levels of salt adulteration in honeysuckle samples was achieved, with optimal PLS regression models obtained by synergy interval PLS and backward interval PLS algorithms.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
Mengmeng Song, Shixing Zhu, Zihao Jiao, Zhisong Ou, Ya Liu, Liejin Guo
Summary: In this study, the various structures and charge characteristics of supercritical water with different densities were investigated using first-principles molecular dynamic method. It was found that supercritical water has a looser structure and weaker polarity than liquid water, promoting the solubility of organics and reactivity of water. The hydrogen bonds and spectrum of supercritical water change as the temperature rises, especially upon crossing the supercritical point.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Zhongyue Guo, Yeran Bai, Meng Zhang, Lu Lan, Ji-Xin Cheng
Summary: Antimicrobial resistance poses a major threat to global health and economics, necessitating rapid AST methods. We introduce a rapid AST method based on wide-field mid-infrared photothermal imaging, capable of metabolic imaging for hundreds of bacteria at single-cell resolution within seconds. This method enables probing of perturbed microbial protein synthesis within 1 hour after antibiotic treatment in E. coli cells, providing insights into antibiotic susceptibility.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, Legal
Tugba Unsal Sapan, Aysun Gungor, Nurdan Sandikci, Alihan Kocabas, Sevil Atasoy
Summary: Research shows that DNA can still be extracted from washed semen stains, providing hope for victims who are unable to immediately seek legal help and think that washing their clothes would eliminate evidence.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Spectroscopy
Dongdong Ni, Heather E. Smyth, Michael J. Gidley, Daniel Cozzolino
Summary: This study aimed to compare the spectral characteristics of dry and whole saliva samples and to investigate the influence of gender and age on MIR spectra. The results showed that dried saliva spectra were more consistent and better at distinguishing individual differences. Specific MIR regions associated with age and gender were identified, particularly in relation to proteins and DNA.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Optics
Xiaohui Li, Xiwei Huang, Xichen Hu, Xiaoxiao Guo, Yueheng Han
Summary: In the past two decades, there have been significant advancements in the development of inexpensive, compact, and efficient mid-infrared pulsed fiber laser technology. Mid-infrared fibers have also become more mature with diverse saturable absorbers. The application of these lasers has expanded to various fields such as molecular spectroscopy, material processing, laser surgery, and biology.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
A. Schade, A. Bader, T. Huber, S. Kuhn, T. Czyszanowski, A. Pfenning, M. Rygala, T. Smolka, M. Motyka, G. Sek, F. Hartmann, S. Hoefling
Summary: We successfully fabricated monolithic high contrast gratings (MHCG) based on GaSb/AlAs0.08 Sb0.92 epitaxial structures with sub-wavelength gratings, which enable high reflection of unpolarized mid-infrared radiation. By studying the relationship between reflectivity wavelength and ridge width (ranging from 220 to 984 nm), we found that the peak reflectivity of above 0.7 can be shifted from 3.0 to 4.3 pm, respectively. The experiment results are in agreement with numerical simulations, demonstrating the process flexibility of MHCG in terms of peak reflectivity and wavelength selection. This work challenges the previous notion that MHCG only provides high reflection for selected light polarization, and shows that thoughtfully designed MHCG allows for high reflectivity for both orthogonal polarizations simultaneously. MHCGs are promising candidates for replacing traditional mirrors like distributed Bragg reflectors in the mid-infrared spectral region to realize resonator-based optical and optoelectronic devices. The importance of this work is rated as 8 out of 10.
Article
Chemistry, Analytical
Gang Qu, Yuxin Zhao, Qiaoli Zhang, Jina Wu, Xiaosen Li, Yang Yang, Shilei Liu
Summary: In this study, magnetic mesoporous materials combined with real-time in situ mass spectrometry were used for the high-throughput detection of hydrolyzed products of organophosphorus nerve agents. The method showed good linearity, low limits of detection and quantification, and high extraction recoveries. The magnetic preparation method used was quick, cost-effective, rugged, and safe. The results demonstrated the potential of this method for rapid and efficient determination of the target analytes in environmental samples.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Anna Hildebrand, Mariam Merchant, Danny O'Hare
Summary: Substandard and falsified artemisinin derivatives in antimalarials have caused significant deaths and economic losses. This study evaluates the feasibility of voltammetric methods for identifying and quantifying artemether. The findings suggest that electrochemical analysis shows promise as a method for artemether identification and quantification.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Marx Osorio Araujo Pereira, Alvaro Ferreira Junior, Edson Silvio Batista Rodrigues, Helena Mulser, Giovanna Nascimento de Mello e Silva, Wallans Torres Pio dos Santos, Eric de Souza Gil
Summary: Brazilian spotted fever (BSF) is a serious and rapidly evolving disease. A new impedimetric immunosensor was developed for rapid diagnosis by measuring specific antibodies in plasma. The sensor demonstrated selectivity and accuracy, and has potential for important applications in diagnostic testing.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Kathrin Schilling, Ronald A. Glabonjat, Olgica Balac, Marta Galvez-Fernandez, Arce Domingo-Relloso, Vesna Slavkovich, Jeff Goldsmith, Miranda R. Jones, Tiffany R. Sanchez, Ana Navas-Acien
Summary: Analysis of trace elements in urine is an important tool for assessing exposures, diagnosing nutritional status, and guiding public health and healthcare intervention. This study provides a sensitive method for analyzing 18 elements in urine samples, using only 100 μL. The results show good accuracy and sensitivity of the method.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Mengya Li, Shijie Liu, Shiliang Guo, Dong Liang, Miaoyun Li, Yaodi Zhu, Lijun Zhao, Jong-Hoon Lee, Gaiming Zhao, Yangyang Ma, Yanxia Liu
Summary: In this study, a magnetic flow device was developed to purify spores in a culture medium system. The device used magnetic nanoparticles to absorb vegetative cells, separating them from the spores. The achieved purity of the collected spores was over 95%. The study also demonstrated a rapid quantitative detection method using Raman spectroscopy.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Wanqiong Liu, Zixuan Wu, Jianwei Peng, Zebin Xu, Yong Liang
Summary: Metal-organic frameworks (MOFs) are effective carriers for molecular imprinting, but their poor dispersibility in aqueous solution is a significant drawback. In this study, we have applied amphiphilic block copolymers and molecularly imprinted technology on MOFs to improve the hydrophilicity of molecularly imprinted fluorescent materials.
ANALYTICAL METHODS
(2024)
