PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort

PCSK9 induces a pro-inflammatory response in macrophages

(2018) Chiara Ricci et al.   Scientific Reports

HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock

(2018) Faheem W. Guirgis et al.   PLoS One

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies

(2017) Christian M Madsen et al.   EUROPEAN HEART JOURNAL

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

(2017) Jean-Mathieu Berger et al.   JOURNAL OF LIPID RESEARCH

Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study

(2017) Frederick J Raal et al.   Lancet Diabetes & Endocrinology

Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis*

(2016) Henry E. Wang et al.   CRITICAL CARE MEDICINE

Lipid metabolism in critical illness

(2016) Pnina Green et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Decreased serum PCSK9 levels after ischaemic stroke predict worse outcomes

(2016) Luca Liberale et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A review of PCSK9 inhibition and its effects beyond LDL receptors

(2016) Dave L. Dixon et al.   Journal of Clinical Lipidology

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

(2016) John H. Boyd et al.   Journal of Innate Immunity

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis

(2016) Dhruva J. Dwivedi et al.   SHOCK

Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor

(2016) Elena Topchiy et al.   PLoS One

Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line

(2015) Massimiliano Ruscica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study

(2015) Thomas Clark Powell et al.   BMC Nephrology

Low Preoperative Cholesterol Level Is a Risk Factor of Sepsis and Poor Clinical Outcome in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass*

(2014) Laurent Lagrost et al.   CRITICAL CARE MEDICINE

A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia

(2014) Dirk J. Blom et al.   NEW ENGLAND JOURNAL OF MEDICINE

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

(2014) K. R. Walley et al.   Science Translational Medicine

High-Sensitivity C-Reactive Protein and Risk of Sepsis

(2013) Henry E. Wang et al.   PLoS One

Epidemiology of severe sepsis

(2013) Florian B Mayr et al.   Virulence

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

(2012) Greg S Martin   Expert Review of Anti-Infective Therapy

Clinical aspects of PCSK9

(2011) Bertrand Cariou et al.   ATHEROSCLEROSIS

Lipoproteins and CETP levels as risk factors for severe sepsis in hospitalized patients

(2010) Cintia M. C. Grion et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Longitudinal Association of PCSK9 Sequence Variations With Low-Density Lipoprotein Cholesterol Levels

(2009) Chiang-Ching Huang et al.   Circulation-Cardiovascular Genetics