The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity
Authors
Keywords
Hypoxia, Cell cycle and cell division, Glucose metabolism, Protein interaction networks, Proteomes, Cell death, Carcinogenesis, Cloning
Journal
PLoS One
Volume 14, Issue 2, Pages e0208287
Publisher
Public Library of Science (PLoS)
Online
2019-02-07
DOI
10.1371/journal.pone.0208287
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
- (2018) Len Neckers et al. CELL STRESS & CHAPERONES
- Hsp70-associated chaperones have a critical role in buffering protein production costs
- (2018) Zoltán Farkas et al. eLife
- Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition
- (2018) M. Pastorek et al. PLoS One
- Drug Resistance Driven by Cancer Stem Cells and Their Niche
- (2017) Marta Prieto-Vila et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments
- (2017) Georg Fluegen et al. NATURE CELL BIOLOGY
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells
- (2017) C. Subramanian et al. NEOPLASIA
- Cancer Stem Cells: Basic Concepts and Therapeutic Implications
- (2016) Dany Nassar et al. Annual Review of Pathology-Mechanisms of Disease
- To wake up cancer stem cells, or to let them sleep, that is the question
- (2016) Shoichiro Takeishi et al. CANCER SCIENCE
- A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation
- (2016) Pablo C. Echeverría et al. MOLECULAR AND CELLULAR BIOLOGY
- The epichaperome is an integrated chaperome network that facilitates tumour survival
- (2016) Anna Rodina et al. NATURE
- jPOSTrepo: an international standard data repository for proteomes
- (2016) Shujiro Okuda et al. NUCLEIC ACIDS RESEARCH
- Heat Shock Proteins Promote Cancer: It's a Protection Racket
- (2016) Stuart K. Calderwood et al. TRENDS IN BIOCHEMICAL SCIENCES
- The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
- (2016) Mark R. Woodford et al. Nature Communications
- Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
- (2016) Mark R. Woodford et al. Cell Reports
- Modifiers of the Genotype–Phenotype Map: Hsp90 and Beyond
- (2016) Rachel Schell et al. PLOS BIOLOGY
- Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma
- (2015) Dong-wang Zhu et al. CANCER LETTERS
- Transcriptome and proteome analysis of Eucalyptus infected with Calonectria pseudoreteaudii
- (2015) Quanzhu Chen et al. Journal of Proteomics
- A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species
- (2015) Hongliang Zong et al. Cell Reports
- HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models
- (2014) Luke Whitesell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype
- (2014) Bojana Gligorijevic et al. PLOS BIOLOGY
- Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies
- (2013) U. Nayar et al. BLOOD
- iTRAQ protein profile analysis of Citrus sinensis roots in response to long-term boron-deficiency
- (2013) Lin-Tong Yang et al. Journal of Proteomics
- Erratum: Corrigendum: Global quantification of mammalian gene expression control
- (2013) Björn Schwanhäusser et al. NATURE
- Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy
- (2013) Ivo Fierro-Monti et al. PLoS One
- Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells
- (2012) Che-Hsin Lee et al. BIOCHIMIE
- Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics
- (2012) Armin Haupt et al. BMC CANCER
- HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells
- (2012) B. Newman et al. CANCER RESEARCH
- Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
- (2012) Mikko Taipale et al. CELL
- Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
- (2012) L. Neckers et al. CLINICAL CANCER RESEARCH
- Aneuploidy causes proteotoxic stress in yeast
- (2012) A. B. Oromendia et al. GENES & DEVELOPMENT
- Topological analysis and interactive visualization of biological networks and protein structures
- (2012) Nadezhda T Doncheva et al. Nature Protocols
- Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
- (2011) Komal Jhaveri et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Stem Cell Quiescence
- (2011) L. Li et al. CLINICAL CANCER RESEARCH
- Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis
- (2011) Chengkai Dai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response
- (2011) Kirti Sharma et al. MOLECULAR & CELLULAR PROTEOMICS
- Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
- (2011) Kamalika Moulick et al. Nature Chemical Biology
- An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine
- (2011) Pablo C. Echeverría et al. PLoS One
- Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms
- (2010) Daniel F. Jarosz et al. Annual Review of Genetics
- ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90
- (2010) Andrew J. Massey JOURNAL OF MEDICINAL CHEMISTRY
- ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
- (2009) Gabriela Bindea et al. BIOINFORMATICS
- A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
- (2009) Ji Luo et al. CELL
- Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
- (2009) E. Caldas-Lopes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
- (2008) Sofia Barluenga et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now