- Home
- Publications
- Publication Search
- Publication Details
Title
Racemic drug resolution: a comprehensive guide
Authors
Keywords
-
Journal
Analytical Methods
Volume 8, Issue 42, Pages 7567-7586
Publisher
Royal Society of Chemistry (RSC)
Online
2016-10-05
DOI
10.1039/c6ay02015a
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development
- (2016) Matthias Manne Knopp et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Synthesis and optical properties of enantiomeric cinchonidine/cinchonine-terpyridine derivatives and their metal complexes
- (2016) Hui-Ting Wang et al. JOURNAL OF LUMINESCENCE
- Recent advances in capillary electrophoresis instrumentation for the analysis of explosives
- (2016) Matías Calcerrada et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Characterization and classification of stationary phases in HPLC and SFC – a review
- (2015) Charlene Galea et al. ANALYTICA CHIMICA ACTA
- Supramolecular Guest–Host Interactions for the Preparation of Biomedical Materials
- (2015) Christopher B. Rodell et al. BIOCONJUGATE CHEMISTRY
- Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: a dramatic ligand effect on the diastereoselectivity
- (2015) Ya-Jing Chen et al. CHEMICAL COMMUNICATIONS
- Viedma ripening: a reliable crystallisation method to reach single chirality
- (2015) Leyla-Cann Sögütoglu et al. CHEMICAL SOCIETY REVIEWS
- Determination of the Enantiomeric Purity of Trelagliptin by Pre-Column Derivatization and Liquid Chromatography on a Chiral Stationary Phase
- (2015) Qi Wang et al. CHROMATOGRAPHIA
- Continuous Preferential Crystallization of Chiral Molecules in Single and Coupled Mixed-Suspension Mixed-Product-Removal Crystallizers
- (2015) Kamila Galan et al. CRYSTAL GROWTH & DESIGN
- Gas chromatographic method for the determination of lumefantrine in antimalarial finished pharmaceutical products
- (2015) Sultan Suleman et al. JOURNAL OF FOOD AND DRUG ANALYSIS
- An Ultimate Stereocontrol in Asymmetric Synthesis of Optically Pure Fully Aromatic Helicenes
- (2015) Michal Šámal et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts
- (2015) Tetsu Tsubogo et al. NATURE
- d-Glucosamine as a novel chiral auxiliary for the stereoselective synthesis of P-stereogenic phosphine oxides
- (2015) A. D'Onofrio et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Chiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic drug ( R )-lacosamide
- (2015) Eswar K. Aratikatla et al. TETRAHEDRON LETTERS
- Chiral liquid membrane for enantioselective separation of racemic ibuprofen by l-tartaric acid derivatives
- (2015) Fan Zhang et al. RSC Advances
- Rapid Discrimination for Traditional Complex Herbal Medicines from Different Parts, Collection Time, and Origins Using High-Performance Liquid Chromatography and Near-Infrared Spectral Fingerprints with Aid of Pattern Recognition Methods
- (2015) Haiyan Fu et al. Journal of Analytical Methods in Chemistry
- A simple and rapid method for chiral separation of amlodipine using dual chiral mobile phase additives
- (2014) Jiaqi Xie et al. Analytical Methods
- A study of supramolecular host–guest interaction of dothiepin and doxepin drugs with cyclodextrin macrocycles
- (2014) N. Rajendiran et al. JOURNAL OF MOLECULAR STRUCTURE
- Emergence of single-molecular chirality from achiral reactants
- (2014) René R. E. Steendam et al. Nature Communications
- Prediction of the efficiency of diastereoisomer separation on the basis of the behaviour of enantiomeric mixtures
- (2014) Emese Pálovics et al. RSC Advances
- An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles
- (2013) Marcus Baumann et al. Beilstein Journal of Organic Chemistry
- A rapid alternative to X-ray crystallography for chiral determination: Case studies of vibrational circular dichroism (VCD) to advance drug discovery projects
- (2013) Steven S. Wesolowski et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Influence of Temperature, Ultrasonication and Chiral Mobile Phase Additives on Chiral Separation: Predominant Influence of β-Cyclodextrin Chiral Mobile Phase Additive Under Ultrasonic Irradiation
- (2013) Jae Hwan Lee et al. BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution
- (2013) Lei Hu et al. CHEMICAL COMMUNICATIONS
- Recent Advances in Mass Spectrometry for the Identification of Neurochemicals and their Metabolites in Biofluids
- (2013) Suresh Kailasa et al. Current Neuropharmacology
- Enantiomeric Separation of Linezolid by Chiral Reversed-Phase Liquid Chromatography
- (2013) R. Nirogi et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- Recent Advances in SPE-Chiral-HPLC Methods for Enantiomeric Separation of Chiral Drugs in Biological Samples
- (2013) I. Ali et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- Review of advances in the thin layer chromatography of pesticides: 2010–2012
- (2013) Joseph Sherma JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
- Indirect hydrogen analysis by gas chromatography coupled to mass spectrometry (GC-MS)
- (2013) V. Varlet et al. JOURNAL OF MASS SPECTROMETRY
- Asymmetric Aminolytic Kinetic Resolution of Racemic Epoxides Using Recyclable Chiral Polymeric Co(III)-Salen Complexes: A Protocol for Total Utilization of Racemic Epoxide in the Synthesis of (R)-Naftopidil and (S)-Propranolol
- (2013) Manish Kumar et al. JOURNAL OF ORGANIC CHEMISTRY
- Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids
- (2013) Syeda Rubab et al. MOLECULES
- Asymmetric synthesis of drug-like spiro[chroman-3,3′-indolin]-2′-ones through aminal-catalysis
- (2013) Dhevalapally B. Ramachary et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach
- (2013) Gopal L. Khatik et al. TETRAHEDRON LETTERS
- The role of biocatalysis in the asymmetric synthesis of alkaloids
- (2013) Joerg H. Schrittwieser et al. RSC Advances
- Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards
- (2012) F. G. Sánchez et al. BIOMEDICAL CHROMATOGRAPHY
- Chiral recognition of doxazosin enantiomers in 3 targets for therapy as well as adverse drug reactions in animal experiments
- (2012) Ding Zhao et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Diastereomeric Resolution of Racemico-Chloromandelic Acid
- (2012) Pei Wang et al. CHIRALITY
- The Dutch Resolution Method: Attempted Enhanced Selectivity of 2-Butylamine with Mixed Diol Hosts
- (2012) Nikoletta B. Báthori et al. CRYSTAL GROWTH & DESIGN
- Determination of absolute chirality using resonant X-ray diffraction
- (2012) Y. Tanaka et al. European Physical Journal-Special Topics
- Microscale 2D separation systems for proteomic analysis
- (2012) Xin Xu et al. Expert Review of Proteomics
- Polarimetric Detection in HPLC of R(-)-Naproxen: Features and Intrinsic Weakness
- (2012) J. Polanski et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- Development of Three End-Capped Para-Benzoyl Calix[4,6, or 8]arene Bonded Stationary Phases for HPLC
- (2012) K. Hu et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- Supercritical fluid chromatography for the enantioseparation of pharmaceuticals
- (2012) Katrijn De Klerck et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- A Hybrid Mechanism in Chiral Discrimination Induced by Crystallization of Supramolecular Compounds
- (2012) Youness Amharar et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The Importance of Attractive Three-Point Interaction in Enantioselective Surface Chemistry: Stereospecific Adsorption of Serine on the Intrinsically Chiral Cu{531} Surface
- (2012) Tugce Eralp et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enantiomeric resolution of chiral aromatic sulfoxides on non-commercial microcrystalline cellulose triacetate and commercial cellulose acetate plates
- (2012) Massimo Bubba et al. JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
- Precise and rapid detection of optical activity for accumulative femtosecond spectroscopy
- (2012) Andreas Steinbacher et al. OPTICS EXPRESS
- Chemoenzymatic synthesis of piperoxan, prosympal, dibozane, and doxazosin
- (2012) Abdul Rouf et al. TETRAHEDRON-ASYMMETRY
- A U–HPLC–ESI–MS/MS–Based Stable Isotope Dilution Method for the Detection and Quantitation of Methotrexate in Plasma
- (2012) Ethan den Boer et al. THERAPEUTIC DRUG MONITORING
- Recent advances in pharmaceutical separations with supercritical fluid chromatography using chiral stationary phases
- (2012) Wang Ren-Qi et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- First enantioseparation and circular dichroism spectra of Au38 clusters protected by achiral ligands
- (2012) Igor Dolamic et al. Nature Communications
- Non-enzymatic dynamic kinetic resolution of racemic α-arylalkanoic acids: an advanced asymmetric synthesis of chiral nonsteroidal anti-inflammatory drugs (NSAIDs)
- (2012) Isamu Shiina et al. Catalysis Science & Technology
- Revisiting Baclofen for the Treatment of Severe Chronic Tinnitus
- (2012) Paul F. Smith et al. Frontiers in Neurology
- Chiral Separations: A Review of Current Topics and Trends
- (2011) Timothy J. Ward et al. ANALYTICAL CHEMISTRY
- Synthesis, crystallization and characterization of diastereomeric salts formed by ephedrine and malic acid in water
- (2011) Han Wu et al. CHEMICAL ENGINEERING SCIENCE
- The Phase Behavior and Crystallization of 2-Chloromandelic Acid: The Crystal Structure of the Pure Enantiomer and the Behavior of Its Metastable Conglomerate
- (2011) Heike Lorenz et al. CRYSTAL GROWTH & DESIGN
- Advances in the enantioseparation of β-blocker drugs by capillary electromigration techniques
- (2011) Zeineb Aturki et al. ELECTROPHORESIS
- A Chiral Pool Strategy for the Synthesis of Enantiopure Hydroxymethyl-Substituted Pyridine Derivatives
- (2011) Christian Eidamshaus et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Novel cyclodextrin chiral stationary phases for high performance liquid chromatography enantioseparation: Effect of cyclodextrin type
- (2011) Xianghua Lai et al. JOURNAL OF CHROMATOGRAPHY A
- Simultaneous determination of selenomethionine enantiomers in biological fluids by stable isotope dilution gas chromatography–mass spectrometry
- (2011) Takehisa Matsukawa et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Enantiomeric Separation and Determination of the Enantiomeric Impurity of Armodafinil by Capillary Electrophoresis with Sulfobutyl Ether-β-cyclodextrin as Chiral Selector
- (2011) Wei Wang et al. MOLECULES
- Rapid Determination of Enantiomeric Excess of α-Chiral Cyclohexanones Using Circular Dichroism Spectroscopy
- (2011) Diana Leung et al. ORGANIC LETTERS
- Asymmetric Total Synthesis of the Antimalarial Drug (+)-Mefloquine Hydrochloride via ChiralN-Amino Cyclic Carbamate Hydrazones
- (2011) John D. Knight et al. ORGANIC LETTERS
- Three Point Chiral Recognition and Resolution of Amino Alcohols Through Well-Defined Interaction Inside a Metallocavity
- (2010) Subash C. Sahoo et al. CHEMISTRY-A EUROPEAN JOURNAL
- Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy
- (2010) Kyu Sung Heo et al. CHIRALITY
- An improved method for determining enantiomeric excess by 13C-NMR in chiral liquid crystal media
- (2010) Vasilios M. Marathias et al. CHIRALITY
- Racemic Compound, Conglomerate, or Solid Solution: Phase Diagram Screening of Chiral Compounds
- (2010) Sukanya Srisanga et al. CRYSTAL GROWTH & DESIGN
- Chiral Separation of Pharmaceuticals by High Performance Liquid Chromatography
- (2010) Yiwen Zhang et al. Current Pharmaceutical Analysis
- Tolerability and effectiveness of (S)-amlodipine compared with racemic amlodipine in hypertension: A systematic review and meta-analysis
- (2010) Fang Liu et al. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
- Complete Enantioseparation through Supramolecular Complex Formation between Tris(1,3-diaminopropane)cobalt(III) Phosphate and β-Cyclodextrin, [Co(tn)3]PO4·β-CDX
- (2010) Natsuki Ohta et al. INORGANIC CHEMISTRY
- A general HPLC–UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices
- (2010) Ravi Shankar Prasad Singh et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Bio- and chemo-catalytic preparations of chiral epoxides
- (2010) Seungha Hwang et al. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Enantiomeric 3-Chloromandelic Acid System: Binary Melting Point Phase Diagram, Ternary Solubility Phase Diagrams and Polymorphism
- (2010) Tam Le Minh et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched α-glucan
- (2010) Thomas J. Boltje et al. Nature Chemistry
- Ketorolac tromethamine: stereo-specific pharmacokinetics and single-dose use in postoperative infants aged 2-6 months
- (2010) Anne M. Lynn et al. PEDIATRIC ANESTHESIA
- Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
- (2010) Katsuhiko Ariga et al. SENSORS
- Dynamic Thermodynamic Resolution: Advantage by Separation of Equilibration and Resolution
- (2009) Won Koo Lee et al. ACCOUNTS OF CHEMICAL RESEARCH
- On circular dichroism and the separation between chromophore and chiral center: The near carbon K-edge X-ray absorption and circular dichroism spectra of noradrenaline and L-DOPA
- (2009) Sebastien Villaume et al. CHIRALITY
- Dextromethorphan-induced serotonin syndrome
- (2009) Anna R. Schwartz et al. CLINICAL TOXICOLOGY
- HPLC method for determination of enantiomeric purity of a novel respiratory fluoroquinolone: WCK 1152
- (2009) RD Yeole et al. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Lipase-mediated enantioselective kinetic resolution of racemic acidic drugs in non-standard organic solvents: Direct chiral liquid chromatography monitoring and accurate determination of the enantiomeric excesses
- (2009) Ashraf Ghanem et al. JOURNAL OF CHROMATOGRAPHY A
- The binary phase diagram of propranolol hydrochloride and crystallization‐based enantioseparation
- (2009) Daniel Polenske et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Simple, Rapid, Sensitive, and Versatile SWNT−Paper Sensor for Environmental Toxin Detection Competitive with ELISA
- (2009) Libing Wang et al. NANO LETTERS
- Impact of Entropic Effects in the Classical Resolution of a 2-Arylpyrrolidine†
- (2009) David M. Barnes et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Membranes and membrane processes for chiral resolution
- (2008) Rui Xie et al. CHEMICAL SOCIETY REVIEWS
- Potential of different techniques of preferential crystallization for enantioseparation of racemic compound forming systems
- (2008) Daniel Polenske et al. CHIRALITY
- Chiral recognition mechanisms with macrocyclic glycopeptide selectors
- (2008) Alain Berthod CHIRALITY
- Quantification of salsolinol enantiomers by stable isotope dilution liquid chromatography with tandem mass spectrometric detection
- (2008) Min Cai et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Determination of enantiomeric compositions of DOPA by tandem mass spectrometry using the kinetic method with fixed ligands
- (2008) Min-Kwon Lee et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Effect of mobile phase additive on chiral separation
- (2008) Li-Ming Yuan SEPARATION AND PURIFICATION TECHNOLOGY
- Lipase-catalyzed kinetic resolution of racemic 1-heteroarylethanols—experimental and QM/MM study
- (2008) Monica Toşa et al. TETRAHEDRON-ASYMMETRY
- Is the required therapeutic effect always achieved by racemic switch of proton-pump inhibitors?
- (2008) Quan Zhou et al. WORLD JOURNAL OF GASTROENTEROLOGY
- The use of X-ray crystallography to determine absolute configuration
- (2007) H. D. Flack et al. CHIRALITY
- Determination of enantiomeric impurity of linezolid by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin
- (2007) Katarzyna Michalska et al. JOURNAL OF CHROMATOGRAPHY A
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started