Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species

Downregulation of HIF-1α inhibits the proliferation, migration and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression

(2018) Jingjing Zhang et al.   BIOSCIENCE REPORTS

WITHDRAWN:Mitochondrial targeting of HIF-1α inhibits hypoxia-induced apoptosis independently of its transcriptional activity

(2018) Hong-Sheng Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apatinib concurrent gemcitabine for controlling malignant ascites in advanced pancreatic cancer patient

(2017) Lijun Liang et al.   MEDICINE

Extraordinary response of metastatic pancreatic cancer to apatinib after failed chemotherapy: A case report and literature review

(2017) Cheng-Ming Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer

(2016) Giandomenico Roviello et al.   CANCER LETTERS

Apatinib in Advanced Gastric Cancer: A Doubtful Step Forward

(2016) Lorenzo Fornaro et al.   JOURNAL OF CLINICAL ONCOLOGY

Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline

(2016) Edward P. Balaban et al.   JOURNAL OF CLINICAL ONCOLOGY

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Apatinib — new third-line option for refractory gastric or GEJ cancer

(2016) Toru Aoyama et al.   Nature Reviews Clinical Oncology

Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

(2016) Pavan P. Adiseshaiah et al.   Nature Reviews Clinical Oncology

Apatinib for the treatment of gastric cancer

(2016) Giandomenico Roviello et al.   Expert Review of Gastroenterology & Hepatology

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Expression and significance of HIF-1α and HIF-2α in pancreatic cancer

(2015) Min Wang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Autophagy, a double-edged sword in anti-angiogenesis therapy

(2015) Jiatao Liu et al.   MEDICAL ONCOLOGY

The Regulation of the Autophagic Network and Its Implications for Human Disease

(2014) Jing Yang et al.   International Journal of Biological Sciences

GDNF increases cell motility in human colon cancer through VEGF–VEGFR1 interaction

(2013) Ssu-Ming Huang et al.   ENDOCRINE-RELATED CANCER

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

(2013) Sampurna Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

(2012) Juefang Ding et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo

(2011) Shu Tian et al.   CANCER SCIENCE

An Update on the Current and Emerging Targeted Agents in Metastatic Colorectal Cancer

(2011) Edward Chu   Clinical Colorectal Cancer

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies

(2010) Jin Li et al.   BMC CANCER

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE