Autophagy, a double-edged sword in anti-angiogenesis therapy

HIF1α Genetic Variants and Protein Expressions Determine the Response to Platinum Based Chemotherapy and Clinical Outcome in Patients with Advanced NSCLC

(2017) Fenglei Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia-induced autophagy promotes human prostate stromal cells survival and ER-stress

(2015) Nan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

(2015) Hui Xu et al.   Oncotarget

Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells

(2015) Hui-Mei Wu et al.   Scientific Reports

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Signaling unmasked

(2014) Morten Petersen et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis

(2014) Y Tian et al.   CELL DEATH AND DIFFERENTIATION

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic

(2014) E.M. Hammond et al.   CLINICAL ONCOLOGY

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells

(2013) M Santoni et al.   BRITISH JOURNAL OF CANCER

TFAP2A Regulates Nasopharyngeal Carcinoma Growth and Survival by Targeting HIF-1  Signaling Pathway

(2013) D. Shi et al.   Cancer Prevention Research

Prognostic and Predictive Value of Tumor Vascular Endothelial Growth Factor Gene Amplification in Metastatic Breast Cancer Treated with Paclitaxel with and without Bevacizumab; Results from ECOG 2100 Trial

(2013) B. P. Schneider et al.   CLINICAL CANCER RESEARCH

Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy

(2013) M. Selvakumaran et al.   CLINICAL CANCER RESEARCH

Lung cancer neovascularisation: Cellular and molecular interaction between endothelial and lung cancer cells

(2013) Sabine Kaessmeyer et al.   IMMUNOBIOLOGY

The Correlation of Expression Levels of HIF-1  and HIF-2  in Hepatocellular Carcinoma with Capsular Invasion, Portal Vein Tumor Thrombi and Patients' Clinical Outcome

(2013) S.-L. Yang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

HIF-1α activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts

(2013) Joseph Hartwich et al.   JOURNAL OF PEDIATRIC SURGERY

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer

(2013) Yuan-yuan Li et al.   LUNG CANCER

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells

(2013) W-T Tai et al.   Cell Death & Disease

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

(2013) Tom Donnem et al.   Cancer Medicine

Bevacizumab plus irinotecan in recurrent malignant glioma shows high overall survival in a multicenter retrospective pooled series of the Spanish Neuro-Oncology Research Group (GEINO)

(2012) Miguel J. Gil et al.   ANTI-CANCER DRUGS

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma

(2012) Xian-ling Guo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-Inducible Factor-1α and Excision Repair Cross-Complementing 1 in Patients with Small Cell Lung Cancer Who Received Front-Line Platinum-Based Chemotherapy: A Retrospective Study

(2012) Gyeong-Won Lee et al.   Journal of Thoracic Oncology

Nicotine Promotes Proliferation of Human Nasopharyngeal Carcinoma Cells by Regulating α7AChR, ERK, HIF-1α and VEGF/PEDF Signaling

(2012) Dingbo Shi et al.   PLoS One

Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer

(2012) Chi-Iou Lin et al.   SURGERY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells

(2011) M. Danielle Bareford et al.   Autophagy

Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis

(2011) Ying-Hong Shi et al.   Autophagy

Changes in blood vessel maturation in the fibrous cap of the tumor rim

(2011) Hisamichi Naito et al.   CANCER SCIENCE

Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

(2011) K. J. Gotink et al.   CLINICAL CANCER RESEARCH

Bevacizumab Has Differential and Dose-Dependent Effects on Glioma Blood Vessels and Tumor Cells

(2011) L. von Baumgarten et al.   CLINICAL CANCER RESEARCH

Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab

(2011) A K Koutras et al.   PHARMACOGENOMICS JOURNAL

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

Acquired Cisplatin Resistance in Human Lung Adenocarcinoma Cells Is Associated with Enhanced Autophagy

(2010) Jing-Hua Ren et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells

(2010) Yuqin Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HIF-1: a key mediator in hypoxia (Review)

(2009) J. Adams et al.   ACTA PHYSIOLOGICA HUNGARICA

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study

(2009) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell

(2009) Hai-yan Xiong et al.   CANCER LETTERS

Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1  Axis

(2009) E. Pencreach et al.   CLINICAL CANCER RESEARCH

Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

(2009) Y.-Q. Xiong et al.   CLINICAL CANCER RESEARCH

Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies

(2009) Annamaria Rapisarda et al.   DRUG RESISTANCE UPDATES

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma

(2009) Robert J. Motzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Resistance to targeted therapy in renal-cell carcinoma

(2009) Brian I Rini et al.   LANCET ONCOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition

(2009) A. Rapisarda et al.   MOLECULAR CANCER THERAPEUTICS

p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas

(2009) Timo Gaiser et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

(2009) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition

(2008) D. T. Dang et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Tumor Escape from Endogenous, Extracellular Matrix-Associated Angiogenesis Inhibitors by Up-Regulation of Multiple Proangiogenic Factors

(2008) N. T. Fernando et al.   CLINICAL CANCER RESEARCH

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

(2008) Leonard B. Saltz et al.   JOURNAL OF CLINICAL ONCOLOGY

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE

Angiogenesis as a strategic target for ovarian cancer therapy

(2008) Whitney A Spannuth et al.   Nature clinical practice. Oncology