Cyclin D–CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB

Abemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2– advanced breast cancer

(2018) Silvia Paola Corona et al.   Drug Design Development and Therapy

How selective are pharmacological inhibitors of cell cycle-regulating cyclin-dependent kinases?

(2018) Radek Jorda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinoma

(2017) Angela B. Ortiz et al.   PLoS One

The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

(2017) Christina FS Mages et al.   eLife

Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family

(2016) Tyler J. Liban et al.   JOURNAL OF MOLECULAR BIOLOGY

A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy

(2016) James MacDonald et al.   MOLECULAR CANCER RESEARCH

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block

(2016) Nurshamimi Nor Rashid et al.   Virology Journal

Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters

(2016) Aimee H. Marceau et al.   Nature Communications

RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells

(2016) Sonja Hesbacher et al.   Oncotarget

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo

(2016) Junko Odajima et al.   PLoS Genetics

Structural mechanisms of DREAM complex assembly and regulation

(2015) Keelan Z. Guiley et al.   GENES & DEVELOPMENT

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer

(2015) Bo Tang et al.   Scientific Reports

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The CHR site: definition and genome-wide identification of a cell cycle transcriptional element

(2014) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

The DREAM Complex Mediates GIST Cell Quiescence and Is a Novel Therapeutic Target to Enhance Imatinib-Induced Apoptosis

(2013) S. Boichuk et al.   CANCER RESEARCH

Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain

(2013) Jason R. Burke et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

(2012) S. Sadasivam et al.   GENES & DEVELOPMENT

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Correction: Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7

(2012) Juliette Adjo Aka et al.   PLoS One

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

(2011) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner

(2009) Fabienne Schmit et al.   FEBS Journal

The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras

(2009) V M Ho et al.   ONCOGENE

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis

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