Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 20, Pages 10275-10283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b03011
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Funding
- National Natural Science Foundation of China [31471693]
- Chinese Universities Scientific Fund for Graduate Students of the China Agricultural University [2016SP003]
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Owing to diverse functionalities and metal binding abilities, proteins have been proven to be promising ligands in the synthesis of gold nanoclusters (Au NCs). In this work, we explored beta-lactoglobnlin (beta-Lg), a protein byproduct generated during cheese processing, as a biotemplate for fabrication of Au NCs by a facile and green method for the first time. The as-prepared Au NCs are water soluble and highly fluorescent and exhibit high sensitivity and selectivity for Hg2+ detection in aqueous solution. Interestingly, we found that the fluorescence of these Au NCs is stable either in a variety of complex matrixes or over a broad pH range (5.0-13.9) and; therefore can be explored as a cell and animal imaging agent. More importantly, we demonstrated that the beta-lactoglobulin-stabilized Au NCs (beta-Lg-Au NCs) could serve as a sensor for the detection and quantification of Hg2+ in beverages, urine, and serum with high sensitivity.
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