Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 8, Pages 4183-4187Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b00503
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Funding
- 973 Program [2012CB932600]
- National Natural Science Foundation of China [21327902, 21135003, 21305063]
- Natural Science Funds of Jiangsu Province [BK20130553]
- Fundamental Research Funds for Central Universities [20620140748]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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In this work, direct exciton-plasmon interactions (EPI) between CdS quantum dots (QDs) and Ag nanoparticles (NPs) were invoked ingeniously by catalytic Ag deposition on Au NPs for the stimulation of high efficient damping effect toward the excitonic responses in CdS QDs, on the basis of which a novel photo electrochemical (PEC) bioanalytical format was achieved for sensitive microRNA detection. Specifically, upon the configurational change from the hairpin probe DNA to the Y-shaped ternary conjugate consisting of the original probe DNA, assistant DNA, and the target microRNA, the alkaline phosphatase (ALP) catalytic chemistry would then trigger the transition of the interparticle interplay from the CdS QDs-Au NPs to the CdS QDs-Ag NPs systems for the microRNA detection due to the dependence of the photocurrent quenching on the target concentration. This work not only provided a unique method for EPI generation among the PEC nanosystems but also offered a versatile and general protocol for future PEC bioanalysis development.
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