Article
Chemistry, Multidisciplinary
Hari Kalathil Balakrishnan, Soo Min Lee, Ludovic F. Dumee, Egan H. Doeven, Richard Alexander, Dan Yuan, Rosanne M. Guijt
Summary: 3D printing is used to fabricate devices with micro-level features and through the use of nanoporous materials, porous membranes can be integrated into 3D printed devices. In this study, nanoporous membranes were fabricated using digital light projection (DLP) 3D printing and resin exchange. A functionally integrated device was then created through a simple, semi-automated manufacturing process.
Article
Chemistry, Multidisciplinary
Rui Wang, Yisa Zhou, Ya Zhang, Jian Xue, Jurgen Caro, Haihui Wang
Summary: This study presents a simple and efficient strategy for fabricating ionic COF membranes using electrophoretic deposition, resulting in ultrathin membranes with outstanding performance.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Zhihua Zhou, Yongtao Tan, Qian Yang, Achintya Bera, Zecheng Xiong, Mehmet Yagmurcukardes, Minsoo Kim, Yichao Zou, Guanghua Wang, Artem Mishchenko, Ivan Timokhin, Canbin Wang, Hao Wang, Chongyang Yang, Yizhen Lu, Radha Boya, Honggang Liao, Sarah Haigh, Huibiao Liu, Francois M. Peeters, Yuliang Li, Andre K. Geim, Sheng Hu
Summary: This study investigates nanoporous membranes made from multilayer graphdiyne and finds that they exhibit fast permeation of light gases while suppressing the flow of heavy gases. This phenomenon can be explained by the presence of straight-through holes, where heavy atoms adsorb on the walls, partially blocking the nanoscale permeation.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Zhe Yuan, Guangwei He, Sylvia Xin Li, Rahul Prasanna Misra, Michael S. Strano, Daniel Blankschtein
Summary: This article discusses recent modeling and experimental advances in nanoporous atomically thin membranes for gas separations. It highlights the advantages and challenges involved, as well as proposes future directions for development.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Raul Fernandez-Mateo, Victor Calero, Hywel Morgan, Antonio Ramos, Pablo Garcia-Sanchez
Summary: This paper investigates stationary electroosmotic flows of electrolytes around insulating constrictions induced by low frequency AC electric fields, introducing the concept of concentration-polarization electroosmosis. Experimental results are in qualitative agreement with the model predictions, but trapping of particles in shallow channels is also observed.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Chemical
Peipei Li, Roshni L. Thankamony, Xiang Li, Zhen Li, Xiaowei Liu, Zhiping Lai
Summary: Nanoporous polyethersulfone (PES) membranes with high surface porosity and uniform pore size distribution were prepared by combining phase separation and nonsolvent induced phase inversion, showing potential for molecular size exclusion and protein separation applications.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Engineering, Chemical
Roberto Castro-Munoz, Kumar Agrawal, Zhiping Lai, Joaquin Coronas
Summary: This article discusses the opportunities and challenges of using nanoporous materials for gas separation in emerging energy technologies, such as zeolites, metal-organic materials, and graphene derivatives. It emphasizes the need for improved porosity control of 2D materials and reduction in the selective membrane skin layer. The review also examines various membrane module configurations and process requirements, highlighting the promising future of scaled spiral wound and hollow fiber modules for CO2 and H2 separations. Lastly, the article provides valuable recommendations for researchers in the field.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Environmental
Junjie Deng, Zong Lu, Li Ding, Zhong-Kun Li, Yanying Wei, Jurgen Caro, Haihui Wang
Summary: 2D MXene membranes with large area can be prepared quickly by facile electrophoretic deposition (EPD), showing highly ordered structure and excellent ions rejection, outperforming the traditional vacuum filtration (VF) method in terms of performance and scalability.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Polymer Science
Zhang Wu, Joerg G. Werner, David A. Weitz
Summary: In this study, an asymmetric microcapsule shell architecture was designed to achieve a good combination of desired features, obtained from water-in-oil-in-water double emulsion drops with a graded macroporous shell and dense skin separation layer.
Article
Nanoscience & Nanotechnology
Chi Cheng, Sathvik Ajay Iyengar, Rohit Karnik
Summary: This study investigates molecular transport in various organic liquids under subnanometre confinement using a chemically robust nanoporous graphene membrane. The results demonstrate that the nature of the solvent can modulate solute diffusion across graphene nanopores, leading to breakdown of continuum flow when pore size approaches the solvent's smallest molecular cross-section. The research highlights the potential of nanoporous graphene as a rich materials system for controlling subcontinuum flow and enabling new membranes for challenging separation needs.
NATURE NANOTECHNOLOGY
(2021)
Review
Engineering, Environmental
Muhammad Bilal Asif, Sidra Iftekhar, Tahir Maqbool, Biplob Kumar Pramanik, Shamas Tabraiz, Mika Sillanpaa, Zhenghua Zhang
Summary: The application and research of two-dimensional (2D) membranes in water purification have made significant progress, especially in materials like graphene. However, challenges remain in industrial production, particularly in large-scale fabrication of nanoporous membranes and ensuring membrane stability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xu Zhang, Zhaowei Tong, Chao Liu, Lei Ye, Yuwei Zhou, Qin Meng, Guoliang Zhang, Congjie Gao
Summary: In this study, PDMS-functionalized MOF-derived nanoporous carbon was used as a compatible nanofiller to blend with the polymer on a PVDF substrate. The method simplified the operation steps, solved the problem of aggregation, and effectively eliminated the interface defect.
Article
Engineering, Chemical
Qing Wang, Nong Xu, Qiao Liu, Qiang Dong, Hiroki Nagasawa, Masakoto Kanezashi, Rongfei Zhou, Toshinori Tsuru
Summary: The physicochemical and pore structural variations of SiC-based membranes derived from different air-curing and pyrolysis temperatures were systematically investigated. The performance of these membranes in the separation of various organic mixtures was evaluated, with the most outstanding results achieved by SiC-based membranes with a pore size of 0.50 nm that were air-cured at 150 degrees C and pyrolyzed at 750 degrees C.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Analytical
Yangchang Cheng, Shaohua Zhang, Lili Qin, Junxiang Zhao, Hua Song, Yang Yuan, Jiashu Sun, Fei Tian, Chao Liu
Summary: In this study, a microfluidic method based on poly(ethylene oxide) (PEO) concentration gradient was developed for rapid, label-free, and highly efficient isolation of circulating tumor cells (CTCs) from whole blood samples. By co-injecting blood sample spiked with 0.025% PEO as the side fluid and 0.075% PEO solution as the center fluid, stable concentration gradients of PEO were formed within the microchannel. The competition between elastic lift force and inertial lift force enabled size-based separation of CTCs and blood cells, with a processing capacity of 1 mL of blood sample in 30 min, separation efficiency >90%, and enrichment ratio >700 for tumor cells. Immunofluorescence staining of the isolated CTCs allowed for accurate discrimination of breast cancer patients from healthy donors with an accuracy of 84.2%. The concentration gradient-based microfluidic separation provides a powerful tool for label-free isolation of CTCs for various clinical applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Sina Moharramzadeh, Say Kee Ong, James Alleman, Kristen S. Cetin
Summary: The combination of using peracetic acid as an oxidizing agent and the progressive freeze concentration process proved to be effective in inhibiting urea hydrolysis and recovering nitrogen in synthetic urine. The experimental results showed that this method can stabilize urea in concentrated synthetic urine and is suitable for urine concentration in source separation systems.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
Daisy Yang, Aliaa Shallan, Michael C. Breadmore, Christopher Greet, Craig Priest
Summary: This study successfully applied an open microfluidic chip for real-time continuous monitoring of EDTA extractable iron in mineral slurries, providing a convenient and efficient analysis method for depressing mineral flotation in mineral processing.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Xinpeng Ren, Sepideh Keshan Balavandy, Feng Li, Michael C. Breadmore, Fernando Maya
Summary: In this study, the effect of thickness and printing orientation on the fabrication of single-material cartridges with built-in porous frits for solid-phase extraction (SPE) using PolyJet 3D printing was investigated. The performance of the 3D printed cartridges was evaluated for the SPE of endocrine-disrupting phenols, and the best overall extraction performance was achieved using the Silica-C18 sorbent. The results demonstrate the suitability of PolyJet 3D printing for fabricating miniaturized cartridges with integrated frits for SPE applications.
ANALYTICA CHIMICA ACTA
(2022)
Article
Multidisciplinary Sciences
Yi Heng Nai, Egan H. Doeven, Rosanne M. Guijt
Summary: This study addressed the complexity issue in the workflow of Nucleic Acid Sequence-Based Amplification (NASBA) by introducing three single-stranded binding proteins, and found that T4 gene gp32 protein showed potential in simplifying the workflow and improving the time-to-positivity.
Article
Materials Science, Multidisciplinary
Lubna Shahzadi, Fernando Maya, Michael C. Breadmore, Stuart C. Thickett
Summary: A new 3D printable resin formulation has been developed and optimized using commercially available thiol and alkyne monomers. The printed objects showed excellent dye removal efficiency, and the resin system has potential applications in water treatment for organic dye removal from wastewater.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Analytical
Hui Yin Tey, Michael C. Breadmore, Hong Heng See
Summary: A polymer inclusion membrane (PIM) based sampling probe was developed for efficient electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dipcoating a nonconductive glass capillary tube in a homogeneous solution consisting of cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2]. The developed technique demonstrated practicality and reliability in extracting doxorubicin from various biological samples, with a quantification limit of 0.2-2 ng/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Mostafa A. Atia, Ria Marni Amuno, Umme Kalsoom, Samantha Ollerton, Alan Rhoden, Paul R. Haddad, Michael C. Breadmore
Summary: This article introduces a fully automated portable capillary electrophoresis instrument for the detection of pharmaceutical residues on surfaces of manufacturing equipment. The instrument has integrated sample swab extraction and can analyze the extracted sample within 1 minute. The method is fast, sensitive, and simple, and provides the possibility for on-site rapid determination of equipment cleanliness in the pharmaceutical industry.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Multidisciplinary
Kolsoum Dalvand, Alireza Ghiasvand, Sepideh Keshan-Balavandy, Feng Li, Michael Breadmore
Summary: This article describes a rapid, simple, and sensitive 3D printed microfluidic device integrated with smartphone-based on-chip detection for POCT quantification of urinary uric acid. The device includes two circular inputs connected to microliter-scale chambers, separated by an integrated porous membrane. Under optimal conditions, the device showed a linear calibration curve in the concentration range of 30-600 mg L-1, with a limit of detection of 10.5 mg L-1. The device was successfully used for the recovery and quantification of uric acid in urine.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Ali Amini, Rosanne M. Guijt, Thomas Themelis, Jelle De Vos, Sebastiaan Eeltink
Summary: DLP 3D printing is an efficient additive manufacturing method for fabricating analytical microdevices. It utilizes a digital micromirror device to direct light and polymerize a liquid resin layer by layer. Advances in vat and lift design, projector technology, and resin composition enable the accurate fabrication of microchannel structures as small as 18 x 20 μm. This review presents the latest advances in DLP 3D printing technology, including instrument set-up and resin formulation, and highlights key efforts in fabricating microdevices for emerging (bio-)analytical chemistry applications such as colorimetric assays, extraction, and separation.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Suleman A. Naz, Van Thanh Huynh, Egan H. Doeven, Scott Adams, Abbas Kouzani, Rosanne M. Guijt
Summary: The adoption of mechatronic approaches has been driven by the demand for accurate control of the flowrate/pressure in chemical analytical systems. In the development of portable analytical devices, considering the instrument as a mechatronic system can help mitigate compromises made to decrease space, weight, or power consumption. Closed loop control systems have been effectively used to decrease the difference between desired and realized fluidic output. This review discusses the implementation of control systems for enhanced fluidic control, categorized by pump type, along with advanced control strategies and their implementation in portable analytical systems.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Azadeh Nilghaz, Soo Min Lee, Hongli Su, Dan Yuan, Junfei Tian, Rosanne M. Guijt, Xungai Wang
Summary: We have developed an acoustofluidic platform for efficient homogenization of food samples and subsequent filtration using micropillars and a porous yarn structure. This compact and reliable system showed high sensitivity in detecting Escherichia coli (E. coli) in different berry samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Hari Kalathil Balakrishnan, Soo Min Lee, Ludovic F. Dumee, Egan H. Doeven, Richard Alexander, Dan Yuan, Rosanne M. Guijt
Summary: 3D printing is used to fabricate devices with micro-level features and through the use of nanoporous materials, porous membranes can be integrated into 3D printed devices. In this study, nanoporous membranes were fabricated using digital light projection (DLP) 3D printing and resin exchange. A functionally integrated device was then created through a simple, semi-automated manufacturing process.
Article
Chemistry, Analytical
Hui Yin Tey, Michael C. Breadmore, Hong Heng See
Summary: A polymer inclusion membrane (PIM) based sampling probe was developed to electrokinetically extract drugs from biological fluids. The probe was fabricated using a dipcoating method with a homogeneous PIM solution. The electrokinetic extraction of doxorubicin from human plasma, human serum, and dried blood spot (DBS) was evaluated using LC-MS/MS for quantification. The developed technique offers a more efficient analytical workflow in the laboratory and was integrated into a portable battery-powered device for safe low-voltage electrokinetic extraction.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Hari Kalathil Balakrishnan, Ludovic F. Dumee, Andrea Merenda, Cyril Aubry, Dan Yuan, Egan H. Doeven, Rosanne M. Guijt
Summary: 3D printing is used to fabricate functionally graded porous materials in a single layer by grayscale digital light projection 3D printing of a polymerization-induced phase separation ink. The materials printed from a single ink can have tunable structural properties ranging from effectively dense to porous with interconnected pores. This technique allows for the concurrent formation of heterostructures and porous structures within a layer with high spatial resolution. The fabricated materials show wicking rates and are used for metal sensing in a proof-of-concept membrane-integrated fluidic device.
Article
Chemistry, Analytical
Chloe M. Taylor, Michael C. Breadmore, Nathan L. Kilah
Summary: In this study, we investigated the use of three porphyrin host molecules as visual sensors to detect different sizes of perfluorocarboxylates. By modifying the fluorinated chain lengths, we achieved subtle control over binding preferences and colorimetric responses. UV-visible spectroscopy and ImageJ software analysis were used to relate the RGB information with binding and perceived colors. The visual estimation of PFCA concentrations was formalized using the CIE76 formula, and color charts were produced from raw RGB information. The color responses were parameterized and calibrated using known concentrations, allowing for the estimation of total PFCA concentrations with less than 20% error across a wide range.
SENSORS & DIAGNOSTICS
(2023)
Review
Chemistry, Analytical
Soo Min Lee, Hari Kalathil Balakrishnan, Egan H. Doeven, Dan Yuan, Rosanne M. Guijt
Summary: Nucleic acid amplification testing is an effective method for disease detection and is suitable for point-of-need testing. Sample preparation techniques are crucial for maximizing the sensitivity and reliability of testing. This review focuses on the reagents used in sample preparation for nucleic acid testing and their suitability for use in a portable format.