Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters

Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weedAmaranthus palmeri

(2018) Dal-Hoe Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells

(2018) Teressa Paulsen et al.   TRENDS IN GENETICS

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

(2018) Henrik Devitt Møller et al.   Nature Communications

Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation

(2017) Pankaj Kumar et al.   MOLECULAR CANCER RESEARCH

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

(2017) Kristen M. Turner et al.   NATURE

Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens

(2017) Massa J. Shoura et al.   G3-Genes Genomes Genetics

Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines

(2017) Pamela Mehanna et al.   PLoS One

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

(2015) Laura W. Dillon et al.   Cell Reports

Derivation and characterization of Dicer- and microRNA-deficient human cells

(2014) H. P. Bogerd et al.   RNA

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

(2013) David A. Nathanson et al.   SCIENCE

Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function

(2012) Nathan A. Lemp et al.   NUCLEIC ACIDS RESEARCH

Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells

(2012) Christine I. Seidl et al.   NUCLEIC ACIDS RESEARCH

Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues

(2012) Y. Shibata et al.   SCIENCE

Bending the Rules of Transcriptional Repression: Tightly Looped DNA Directly Represses T7 RNA Polymerase

(2010) Troy A. Lionberger et al.   BIOPHYSICAL JOURNAL

Supercoiling Induces Denaturation Bubbles in Circular DNA

(2010) Jae-Hyung Jeon et al.   PHYSICAL REVIEW LETTERS

Intrinsically bent DNA in replication origins and gene promoters

(2009) F. Gimenes et al.   GENETICS AND MOLECULAR RESEARCH