Article
Biochemistry & Molecular Biology
Aisha Siddiqui, Syafiq Asnawi Zainal Abidin, Zahoor A. Shah, Iekhsan Othman, Yatinesh Kumari
Summary: Globally, around 24 million elderly individuals, mainly those with Alzheimer's disease (AD), are affected by dementia. Despite the availability of multiple treatment options, there is a need to enhance our understanding of the disease's pathogenesis in order to develop disease-modifying therapies. This study utilizes a zebrafish model to investigate the driving mechanisms behind AD development by inducing AD-like conditions using Okadaic acid (OKA). The findings demonstrate significant memory impairment and abnormal gene and protein expression in the zebrafish brain, highlighting the importance of this model for studying AD pathology and drug discovery.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Cell Biology
Francesco Bruno, Paolo Abondio, Rossella Bruno, Leognano Ceraudo, Ersilia Paparazzo, Luigi Citrigno, Donata Luiselli, Giuseppe Passarino, Rosanna Colao, Raffaele Maletta, Alberto Montesanto
Summary: This study summarizes and discusses the etiology of Alzheimer's disease and the hypothesis of viral infection. Viral infection may be an important factor in sporadic AD, including various herpes viruses, flaviviruses, and HIV.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim
Summary: Caffeic acid has the potential to be used as a therapeutic agent for Alzheimer's disease due to its antioxidant and cognitive-enhancing effects. It reduces oxidative stress, regulates the expression of related proteins, decreases inflammation markers, enhances synaptic markers, and reduces the expression of Alzheimer's disease-related proteins.
Article
Clinical Neurology
Bridget Teevan Burke, Caitlin Latimer, C. Dirk Keene, Joshua A. Sonnen, Wayne McCormick, James D. Bowen, Susan M. McCurry, Eric B. Larson, Paul K. Crane
Summary: The AT(N) research framework categorizes eight biomarker profiles using amyloid (A), tauopathy (T), and neurodegeneration (N). Clinical trials would incur substantial expense to characterize AT(N) profiles, with A+T+(N)+ being the most common profile.
ALZHEIMERS & DEMENTIA
(2021)
Review
Neurosciences
Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L. DeVos, Bradley Hyman, Gabriel Chiu, Ethan R. Roy, Wei Cao, Miranda Orr, Virginie Buggia-Prevot, William J. Ray, Bess Frost
Summary: The study reveals that transposable elements are activated in the context of brain aging and tauopathy in mice, with endogenous retrovirus (ERV) class of retrotransposons being particularly enriched. Protein encoded by Intracisternal A-particle is found to be elevated in tau transgenic mouse brains. The research also suggests increased DNA copy number of transposable elements in the brains of tau transgenic mice, indicating potential retrotransposition activity in the context of tauopathy.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Cell Biology
Alejandro R. Roda, Gabriel Serra-Mir, Laia Montoliu-Gaya, Lidia Tiessler, Sandra Villegas
Summary: Alzheimer's disease is a neurodegenerative disease characterized by abnormal accumulation of amyloid-beta and tau proteins. While amyloid-beta accumulation may initiate the pathology, tau protein impairment is likely the main mediator of neurodegeneration. Factors such as the immune system and specific genes are implicated in both amyloid-beta and tau pathologies, and combined therapies targeting both proteins have been proposed as a strategy to stop disease progression.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Byung Hee Han, Brooke Cofell, Emily Everhart, Courtney Humpal, Sam-Sik Kang, Sang Kook Lee, Jeong Sook Kim-Han
Summary: This study demonstrates that the natural polyphenol amentoflavone (AMF) can increase cellular uptake and clearance of amyloid beta-protein (Aβ), potentially offering a therapeutic approach for Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gajendra Choudhary, Manisha Prajapat, Gurjeet Kaur, Harvinder Singh, Saniya Mahendiratta, Ajay Prakash, Bikash Medhi
Summary: This study found that Panobinostat can inhibit HDAC6, enhance NEP levels, and reduce Aβ accumulation in neuronal cells. These findings suggest the potential therapeutic role of Panobinostat in Alzheimer's disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Clinical Neurology
Silvia Ingala, Casper De Boer, Larissa A. Masselink, Ilaria Vergari, Luigi Lorenzini, Kaj Blennow, Gael Chetelat, Carol Di Perri, Michael Ewers, Wiesje M. van der Flier, Nick C. Fox, Juan Domingo Gispert, Sven Haller, Jose Luis Molinuevo, Graciela Muniz-Terrera, Henri J. M. M. Mutsaerts, Craig W. Ritchie, Karen Ritchie, Mark Schmidt, Adam J. Schwarz, Lisa Vermunt, Adam D. Waldman, Joanna Wardlaw, Alle Meije Wink, Robin Wolz, Viktor Wottschel, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof
Summary: The study classified non-demented EPAD participants and assessed their neuropsychological and imaging profiles. Age and cerebrovascular burden progressed with biomarker positivity, with p-tau driving cognitive dysfunction and memory and language domains affected in the earliest stages.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Md. Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan
Summary: Gallagic acid, a constituent of pomegranate extract, shows potential in treating Alzheimer's disease by inhibiting BACE1 and AChE, thereby reducing Aβ peptide accumulation and intracellular reactive oxygen species production.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Laura Schnoeder, Wenqiang Quan, Ye Yu, Inge Tomic, Qinghua Luo, Wenlin Hao, Guoping Peng, Dong Li, Klaus Fassbender, Yang Liu
Summary: In the brains of Alzheimer's disease (AD) mice, deficiency of IKK beta in neurons reduces levels of amyloid-beta-peptide (Aβ) and phosphorylated tau (p-tau), modifies inflammatory activation, and improves cognitive function. The deficiency also decreases BACE1 protein and activity, increases expression of PP2A isoform A, and enhances autophagy. However, the protective effects of IKK beta deficiency differ in APP and tau-transgenic mice. Further studies are needed to understand the interaction between Aβ and p-tau before targeting IKK beta/NF-kappa B for AD therapies.
Review
Chemistry, Multidisciplinary
Shima Tajahmadi, Hossein Molavi, Farhad Ahmadijokani, Amir Shamloo, Akbar Shojaei, Mohammad Sharifzadeh, Mashallah Rezakazemi, Ali Fatehizadeh, Tejraj M. Aminabhavi, Mohammad Arjmand
Summary: Beta-amyloid (Al3) peptide is a key biomarker of Alzheimer's disease (AD), and monitoring its levels is crucial for early diagnosis, prevention, and treatment. Recent attention has focused on the potential of metal-organic frameworks (MOFs) for AD diagnosis and treatment. This review discusses the latest advances in using MOFs for early detection of AD biomarkers, detection of metal ions in the brain, and imaging of Al3 plaques.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Neurosciences
Caleb Pitcairn, Willayat Yousuf Wani, Joseph R. Mazzulli
NEUROBIOLOGY OF DISEASE
(2019)
Article
Cell Biology
JaLessa N. Wright, Gloria A. Benavides, Michelle S. Johnson, Willayat Wani, Xiaosen Ouyang, Luyun Zou, Helen E. Collins, Jianhua Zhang, Victor Darley-Usmar, John C. Chatham
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Aatish Mahajan, Divika Sapehia, Shilpa Thakur, Palani Selvam Mohanraj, Rashmi Bagga, Jyotdeep Kaur
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Leah K. Cuddy, Willayat Y. Wani, Martino L. Morella, Caleb Pitcairn, Kotaro Tsutsumi, Kristina Fredriksen, Craig J. Justman, Tom N. Grammatopoulos, Nandkishore R. Belur, Friederike Zunke, Aarthi Subramanian, Amira Affaneh, Peter T. Lansbury, Joseph R. Mazzulli
Article
Medicine, Research & Experimental
Xiaosen Ouyang, Israr Ahmad, Michelle S. Johnson, Matthew Redmann, Jason Craver, Willayat Y. Wani, Gloria A. Benavides, Balu Chacko, Peng Li, Martin Young, Anil G. Jegga, Victor Darley-Usmar, Jianhua Zhang
LABORATORY INVESTIGATION
(2020)
Review
Biochemistry & Molecular Biology
Jayalakshmi Vallamkondu, Albin John, Willayat Yousuf Wani, Suguru Pathinti Ramadevi, Kishore Kumar Jella, P. Hemachandra Reddy, Ramesh Kandimalla
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cell Biology
Renuka Sharma, Taqveema Ali, Jyotdeep Kaur
Summary: The study evaluated the impact of dietary folate modulations on the expression of tumor suppressor genes during hepatocellular carcinoma development, finding differential expression patterns and promoter methylation in folate deficiency and oversupplemented groups. The results suggest that TSGs play a role in HCC development, with potential contributions from promoter methylation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Taqveema Ali, Roli Saxena, Isha Rani, Renuka Sharma, Deepti More, Rajendra Ola, Stuti Agarwal, Yogesh Kumar Chawla, Jyotdeep Kaur
Summary: This study found the role of IL-18 genetic polymorphisms in the progression from HBV to HCC. Serum IL-18 levels were significantly increased during HCC development. The levels of activated signal transducers of IL-18 in PBMCs also increased during HBV to HCC progression, indicating IL-18 potential as a biomarker for disease progression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Aatish Mahajan, Divika Sapehia, Beenish Rahat, Jyotdeep Kaur
Summary: Maternal folic acid and B-12 status during pregnancy influence fetal growth. This study reveals that altered dietary ratio of folic acid and B-12 affects the regulation of the H19/IGF2 locus in mice.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Neurosciences
Iva Stojkovska, Willayat Y. Wani, Friederike Zunke, Nandkishore R. Belur, Egor A. Pavlenko, Nkatha Mwenda, Karan Sharma, Laetitia Francelle, Joseph R. Mazzulli
Summary: This study found that neurons in Parkinson's disease patients are unable to respond properly to protein misfolding, which is related to the fragmentation of the endoplasmic reticulum and the disruption of protein folding capacity caused by aggregated alpha-synuclein. Enhancing endoplasmic reticulum proteostasis and trafficking can improve lysosomal function and reduce protein aggregation, potentially benefiting the treatment of Parkinson's disease.
Article
Developmental Biology
Divika Sapehia, Aatish Mahajan, Radhika Srinivasan, Jyotdeep Kaur
Summary: This study explored the effects of low vitamin B12 combined with different levels of folic acid on fetal growth parameters and maternal reproductive performance. The results showed that vitamin B12 deficiency and excessive folic acid supplementation resulted in decreased placental and fetal weight in the first generation. Similar effects were also observed in the second generation with decreased placental weight, fetal weight, crown-rump length, and head circumference. Over-supplemented folic acid also affected ovarian follicles and placental pathology.
Article
Biochemistry & Molecular Biology
Divika Sapehia, Aatish Mahajan, Parampal Singh, Jyotdeep Kaur
Summary: This study investigates the effects of dietary vitamin B12 and folic acid on fetal and placental epigenetics. It finds that deficiency in vitamin B12 and high folate levels have a significant impact on the gene expression of MEST and PHLDA2. The study also reveals that DNA methylation changes occur in both generations, while altered histone modifications primarily regulate gene expression in the F1 generation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaosen Ouyang, Willayat Y. Wani, Gloria A. Benavides, Matthew J. Redmann, Hai Vo, Thomas van Groen, Victor M. Darley-Usmar, Jianhua Zhang
Summary: Lysosomes are crucial for protein and organelle degradation and homeostasis, with cathepsins playing a key role in protein quality control. Overexpression of CTSD can reduce the toxicity of protein aggregates and extend the lifespan of certain mutant mice.
ACTA PHARMACEUTICA SINICA B
(2023)