An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling

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Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

(2018) Lining Ju et al.   Nature Communications

Autoregulation of von Willebrand factor function by a disulfide bond switch

(2018) Diego Butera et al.   Science Advances

Microfluidic auto-alignment of protein patterns for dissecting multi-receptor crosstalk in platelets

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Autonomous conformational regulation of β3 integrin and the conformation-dependent property of HPA-1a alloantibodies

(2018) Aye Myat Myat Thinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy landscape differences among integrins establish the framework for understanding activation

(2017) Jing Li et al.   JOURNAL OF CELL BIOLOGY

Force regulated conformational change of integrin α V β 3

(2017) Yunfeng Chen et al.   MATRIX BIOLOGY

Receptor-mediated cell mechanosensing

(2017) Yunfeng Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular adhesion: Instant integrin mechanosensing

(2017) Ning Wang   NATURE MATERIALS

Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species

(2017) Lining Ju et al.   Scientific Reports

Three-Dimensional Structures of Full-Length, Membrane-Embedded Human αIIbβ3 Integrin Complexes

(2016) Xiao-Ping Xu et al.   BIOPHYSICAL JOURNAL

SnapShot: Mechanosensing Matrix

(2016) Jerome Irianto et al.   CELL

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

(2016) Xiaohong Ruby Xu et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

(2016) Wei Deng et al.   Nature Communications

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

(2016) Lining Ju et al.   eLife

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Mechanotransduction and extracellular matrix homeostasis

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Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

The N-terminal Flanking Region of the A1 Domain Regulates the Force-dependent Binding of von Willebrand Factor to Platelet Glycoprotein Ibα

(2013) Lining Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

Modulation of integrin activation and signaling by α1/α1′-helix unbending at the junction

(2013) Chuanmei Zhang et al.   JOURNAL OF CELL SCIENCE

A directional switch of integrin signalling and a new anti-thrombotic strategy

(2013) Bo Shen et al.   NATURE

Swing-Out of the β3 Hybrid Domain Is Required for αIIbβ3 Priming and Normal Cytoskeletal Reorganization, but Not Adhesion to Immobilized Fibrinogen

(2013) Ming Cheng et al.   PLoS One

An Investigation on Platelet Transport during Thrombus Formation at Micro-Scale Stenosis

(2013) Francisco Javier Tovar-Lopez et al.   PLoS One

Resolving Two-dimensional Kinetics of the Integrin αIIbβ3-Fibrinogen Interactions Using Binding-Unbinding Correlation Spectroscopy

(2012) Rustem I. Litvinov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Dissociation of Bimolecular αIIbβ3-Fibrinogen Complex under a Constant Tensile Force

(2011) Rustem I. Litvinov et al.   BIOPHYSICAL JOURNAL

Reconstruction of integrin activation

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Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Closed headpiece of integrin  IIb 3 and its complex with an  IIb 3-specific antagonist that does not induce opening

(2010) J. Zhu et al.   BLOOD

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of platelet thrombus formation

(2009) S. P. JACKSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The structure and function of platelet integrins

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A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

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