Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

(2017) Florian Wiede et al.   JOURNAL OF AUTOIMMUNITY

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza

(2016) Tara M. Strutt et al.   JOURNAL OF IMMUNOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis

(2015) Amy E Anderson et al.   ANNALS OF THE RHEUMATIC DISEASES

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

(2015) Kiyoshi Hirahara et al.   IMMUNITY

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

(2015) Gareth W. Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

(2015) Anneli Peters et al.   JOURNAL OF IMMUNOLOGY

Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter — Determining Validation Requirements

(2015) Frances Humby et al.   JOURNAL OF RHEUMATOLOGY

Super-enhancers delineate disease-associated regulatory nodes in T cells

(2015) Golnaz Vahedi et al.   NATURE

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation

(2015) Dan Lu et al.   NATURE IMMUNOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles

(2015) Anthony Mathelier et al.   NUCLEIC ACIDS RESEARCH

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease

(2015) Robert C. Sharp et al.   Frontiers in Cellular and Infection Microbiology

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells

(2014) E. M. Briso et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

(2014) M. A. Nowell et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

(2014) Claire J Greenhill et al.   ARTHRITIS RESEARCH & THERAPY

PTPN2 attenuates T-cell lymphopenia-induced proliferation

(2014) Florian Wiede et al.   Nature Communications

T cell-intrinsic role of IL-6 signaling in primary and memory responses

(2014) Simone A Nish et al.   eLife

Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

(2013) G W Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Interleukin-6 expands homeostatic space for peripheral T cells

(2013) Changwan Hong et al.   CYTOKINE

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

(2013) Christopher J. Haines et al.   Cell Reports

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease

(2012) Arthur G Pratt et al.   ANNALS OF THE RHEUMATIC DISEASES

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

(2010) Gareth W. Jones et al.   FASEB JOURNAL

Memory CD4 T cells: generation, reactivation and re-assignment

(2010) Megan K.L. MacLeod et al.   IMMUNOLOGY

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells

(2008) Maria Paula Longhi et al.   PLoS Pathogens