Article
Chemistry, Multidisciplinary
Sooyeon Kim, Hanui Jo, Suyeon Lee, Manseok Yang, Hayoung Jun, Youngjong Lee, Gi-Wook Kim, Dongwon Lee
Summary: This study developed T-pBMA nanoparticles as nanotheranostic agents for renal IR injury, which showed targeting ability, H2O2 responsiveness, and the ability to monitor treatment progress through ultrasound imaging.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Anqi Lin, Quanyi Liu, Yihong Zhang, Quan Wang, Sirong Li, Bijun Zhu, Leiying Miao, Yan Du, Sheng Zhao, Hui Wei
Summary: This study develops a universal strategy to measure CAT and CAT-like activity, overcoming the limitations of current assays and facilitating insightful studies on applications of CAT and CAT-like nanozymes. The oxygen-sensitive and H2O2-inhibitory self-polymerization of dopamine is demonstrated as an activity indicator for CAT or CAT-like nanozymes. This assay shows allround advantages in sensitivity, specificity, and versatility.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Steve Huvelle, Thomas Le Saux, Ludovic Jullien, Frederic Schmidt
Summary: A self-immolative spacer based on dissymmetrical N,N '-bis-carbamate aniline is introduced to liberate a substrate from a precursor after dual activation. The proof of principle of its exclusive selectivity for substrate liberation has been conducted on a profluorophore.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Jingmei Guo, Yue Xu, Miaodeng Liu, Jian Yu, Hongye Yang, Wenlong Lei, Cui Huang
Summary: The study successfully developed a Fenton reaction-enhanced antimicrobial sonodynamic therapy platform for root canal disinfection, showcasing strong oxidative capabilities and good biocompatibility. The platform effectively eradicated biofilms and bacteria within root canals.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Xin Wang, Qi Ding, Ying Tian, Wei Wu, Feida Che, Ping Li, Wen Zhang, Wei Zhang, Bo Tang
Summary: This study developed two fluorescent probes to monitor H2O2 in mitochondria and lysosomes. The findings from fluorescence imaging demonstrated that mitochondrial H2O2 is involved in reduced GCase activity in lysosomes in depressed mice, providing a valuable tool for understanding the pathogenesis of depression.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Akalya Karunakaran, Katie J. Francis, Chris R. Bowen, Richard J. Ball, Yuanzhu Zhao, Lina Wang, Neil B. McKeown, Mariolino Carta, Philip J. Fletcher, Remi Castaing, Mark A. Isaacs, Laurence J. Hardwick, Gema Cabello, Igor V. Sazanovich, Frank Marken
Summary: A blue light mediated photochemical process using solid graphitic carbon nitride (g-C3N4) in ambient air/isopropanol vapour is suggested to produce nanophase water inclusions, which can generate approximately 50 μmol H2O2 per gram of g-C3N4. This H2O2 can be stored in the solid g-C3N4 for later release in applications such as disinfection or anti-bacterial surfaces.
CHEMICAL COMMUNICATIONS
(2023)
Article
Environmental Sciences
Faroza Nazir, Qazi Fariduddin, Anjuman Hussain, Tanveer Alam Khan
Summary: This study investigated the effects of brassinosteroids and hydrogen peroxide on tomato plants under copper stress. The results showed that EBL and H2O2 applied through distinct modes could enhance the resilience of tomato plants to copper stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Medicinal
Jun Liu, Jinhua Wang, Shuang Si, Jinyi Xu, Peng Xue
Summary: MIDA boronates in conjunction with naphthalene-based fluorophores are suitable compounds for tumor diagnosis due to their stability, controlled drug release, and potential for precision therapeutics.
Article
Nuclear Science & Technology
Chenxi Hou, Mingjian He, Haofan Fang, Meng Zhang, Yang Gao, Caishan Jiao, Hui He
Summary: Ultrasound-assisted dissolution of U3O8 powder in carbonate solution was studied, and it was found that ultrasound can increase the solubility and dissolution rate of U3O8, accompanied by the crush of U3O8 particles and the reduction of activation energy. However, the distribution of uranyl species and hydrolysis of uranyl complexes were not affected by ultrasound.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Abu Raihan Sarkar, Suman Pal, Ankan Kumar Sarkar, Nikhil R. Jana
Summary: A colloidal nanoparticle form of hemin with intact catalytic performance and high cellular uptake properties is reported in this study. The designed nanoparticles can enter cells, generate oxidative stress, and induce autophagy.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Liangying Jia, Jing Xiao, Jiwei Cui, Jingcheng Hao, Xu Wang
Summary: In this study, a chemiluminescence-based strategy for self-reporting mechanical damage in underwater hierarchical ionic skins (HI-skins) was developed. The self-reporting system showed high mechanical and electronic restorability, excellent stretchability, impressive room-temperature ionic conductivity, and durable strain sensing performance. These self-reporting HI-skins hold great potential for underwater soft ionotronics.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Bingchen Yu, Ting Kang, Yuan Xu, Yiqing Liu, Yaru Ma, Bowen Ke
Summary: Persulfide prodrugs, such as hydrogen persulfide (H2S2), show increased pharmacological activities and reduced toxicity compared to hydrogen sulfide (H2S), indicating their potential as better therapeutic options.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Food Science & Technology
Kexin Xiong, Naihui Dong, Bo Yang, Yingxi Chen, Huipeng Liang, Xinping Lin, Sufang Zhang
Summary: In this study, the oxidation tolerance of 23 different Rhodotorula strains was screened, and a strong positive correlation between ergothioneine (EGT) yield and H2O2 tolerance was observed. The highest reported EGT yield in non-recombinant strains was achieved by a high EGT-producing strain R. mucilaginosa DL-X01. The results provide a potential method for screening high EGT-producing strains and advancing the production of EGT by microorganisms for various industries.
Article
Chemistry, Organic
Rui Chen, Rongchen Wang, Jie Sun, Xuemei Dong, Chengjun Dong, Lixin Sun, Xianfeng Gu, Chunchang Zhao
Summary: An H2O2-activated, endoplasmic reticulum-targeted theranostic probe was developed, which can be activated by H2O2, leading to increased NIR fluorescence and photothermal signals for specific recognition of H2O2 and further photothermal therapy in H2O2-overexpressing cancer cells in the endoplasmic reticulum.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Feiran Liu, Xiaoli Zhang, Jing Jing, Xiaoling Zhang
Summary: Golgi stress is a major stress response in the Golgi apparatus that may disrupt redox balance and be related to various diseases. Hydrogen peroxide (H2O2), an important reactive oxygen species, plays a crucial role in the Golgi apparatus and abnormal concentrations of H2O2 can cause oxidative damage. On the other hand, hydrogen sulfide (H2S) acts as a protective agent to alleviate Golgi stress. A Golgi-targeted fluorescent probe, Golnap-H2O2, has been developed as a specific imaging tool for detecting H2O2 in the Golgi apparatus and as a potential H2S donor for cytoprotection.
Article
Clinical Neurology
Jeong-Hwan Seo, Sung-Woon Baik, Myoung-Hwan Ko, Yu-Hui Won, Sung-Hee Park, Sang Wook Oh, Gi-Wook Kim
Summary: The study compared the pain relief effect of Medial branch nerve block (MBB), Facet joint injections (FJI), and combined treatment with MBB and FJI in patients with axial low back pain. Results showed that all three treatments significantly improved NRS and ODI scores, with no significant difference among the groups. Combined treatment did not have a pain relief effect superior to individual treatments.
PAIN RESEARCH & MANAGEMENT
(2021)
Article
Neurosciences
Dong-Ha Kang, Gi-Wook Kim
Article
Neurosciences
Jin-Kook Lee, Myoung-Hwan Ko, Sung-Hee Park, Gi-Wook Kim
Summary: This study classified aphasia severity using Western Aphasia Battery and identified optimal cut-off values for Language-Related White Matter fibers. Correlations were found between certain white matter tracts and Western Aphasia Battery subscores, indicating potential for predicting language impairment severity in post-stroke aphasia patients using diffusion tensor imaging-based analysis.
Review
Biochemistry & Molecular Biology
Berwin Singh Swami Vetha, Angela Guma Adam, Azeez Aileru
Summary: This paper discusses the application of Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers in the field of inflammation, focusing on their drug delivery capabilities and potential to target ROS. The authors introduce the concepts of oxylate smart polymer-based particles, discuss methods of incorporating small molecules into oxalate backbone for drug delivery, and present novel proof of concepts that have shown effectiveness in disease models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Nam-Gyu Jo, Myoung-Hwan Ko, Yu Hui Won, Sung-Hee Park, Gi-Wook Kim, Jeong-Hwan Seo
Summary: The study evaluated the diagnostic value of DSEPs in radiculopathy patients and found high sensitivity of DSEPs to radiculopathy symptoms. The IVF size was significantly related to dermatomal somatosensory pathway dysfunction, while spinal stenosis and IVF stenosis were not significantly related to DSEPs.
PAIN RESEARCH & MANAGEMENT
(2021)
Article
Biotechnology & Applied Microbiology
Ju-Yul Yoon, Da-Sol Kim, Gi-Wook Kim, Myoung-Hwan Ko, Jeong-Hwan Seo, Yu Hui Won, Sung-Hee Park
Summary: This study investigated motor neuron organization in schizencephaly patients, finding that iMEP response rate is related to hand function involving strength, while the symmetricity of CST by DTI is linked to dexterity-related hand function. Additionally, the symmetry index of DTI was significantly correlated with the outcomes of the B&B test.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Rehabilitation
Choong-Hee Roh, Da-Sol Kim, Gi-Wook Kim, Yu-Hui Won, Sung-Hee Park, Jeong-Hwan Seo, Myoung-Hwan Ko
Summary: The integrated training device for strength and balance showed significant improvements in extremity muscle strength, postural balance, and cognition in older adults after 6 weeks of training. This device may be a safe and useful tool for improving physical and cognitive functions in the elderly.
ANNALS OF REHABILITATION MEDICINE-ARM
(2021)
Article
Medicine, Research & Experimental
Young-In Go, Gi-Wook Kim
Summary: Bilateral multifocal muscular hemorrhage following coronary intervention is rare, but can be effectively managed using medication adjustment, rehabilitation exercises, and treatment to alleviate pain.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Gi-Wook Kim, Nan-Hee Song, Mi-Ran Park, Tae-Eon Kim, Da-Sol Kim, Young-Bin Oh, Dong-Won Lee
Summary: The study aimed to verify the dual role of PVO nanoparticles as both contrast agents and therapeutic agents for musculoskeletal injuries by developing a new approach for ultrasound imaging and treatment.
Article
Neurosciences
Nam-Gyu Jo, Gi-Wook Kim, Yu Hui Won, Sung-Hee Park, Jeong-Hwan Seo, Myoung-Hwan Ko
Summary: The timing of tDCS stimulation is crucial for enhancing motor skill learning, with this study showing that tDCS treatment prior to finger tapping training significantly improves motor skill acquisition. Further research is needed to confirm these findings.
Article
Medicine, Research & Experimental
Yu Hui Won, Da-Sol Kim, Gi-Wook Kim, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo
Summary: Trabeculation grade can be used to classify suprasacral neurogenic bladder. Parameters such as disease duration, bladder capacity, and detrusor pressure show significant differences among different grades of trabeculation. Vesicoureteral reflux has a moderate correlation with trabeculation grade.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Berwin Singh Swami Vetha, Rachel Byrum, Kaisi Peele, Debra Diz, Azeez Aileru
Summary: The over-expression of Ren-2(d) gene in (mRen2)27 rats leads to development of hypertension mediated by the renin-angiotensin-system axis and exaggerated sympathetic nerve activity. Exogenously applied angiotensin II (AngII) on the superior cervical ganglion evokes ganglionic compound action potentials (gCAP) and ganglionic long-term potentiation (gLTP). The study found that postganglionic AngII Type 1 (AT(1)) receptors mediate the prolonged indices of ganglionic transmission in (mRen2)27 rats, while expression of Type 2 (AT(2)), Ang-(1-7)-MAS, and NOX4 proteins is lower, possibly contributing to altered ganglionic sensitivity to AngII.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Young-In Go, Gi-Wook Kim, Yu-Hui Won, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo, Da-Sol Kim
Summary: Dysphagia induced by anterior cervical osteophytes is a common problem in older individuals. Surgical resection is often considered when conservative treatment fails, but its effectiveness is controversial. This case report highlights the challenges and outcomes of surgery for this condition, with subsequent rehabilitation and improvement observed.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Health Care Sciences & Services
Seong-Yeol Kim, Minji Song, Yunju Jo, Youngjae Jung, Heecheon You, Myoung-Hwan Ko, Gi-Wook Kim
Summary: The aim of this study is to investigate the efficacy of home therapy on logopedic and phoniatric abilities in children with articulation disorder using the Smart Speech game interface. The results showed that home-based serious games can be considered an alternative treatment method to improve language function.
JMIR SERIOUS GAMES
(2023)
Article
Health Care Sciences & Services
Nam-Gyu Jo, Seung-Rok Kang, Myoung-Hwan Ko, Ju-Yul Yoon, Hye-Seong Kim, Kap-Soo Han, Gi-Wook Kim
Summary: WBVT training shows certain effectiveness in improving muscle strength and physical performance in older adults, with a greater increase in mean peak torque compared to conventional resistance exercise.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
