Article
Biochemistry & Molecular Biology
Jinsoo Kim, Dohee Ahn, Sang J. Chung
Summary: This study identified chebulinic acid as a potential therapeutic agent for treating obesity by inhibiting PPP1CB activity and suppressing adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan
Summary: The study demonstrated that TSA inhibited adipogenesis in 3T3-L1 preadipocytes by activating the AMPK pathway, leading to decreased lipid accumulation. Furthermore, TSA was also able to reverse the weight gain and adipose tissue increase induced by a high-fat diet in obese mouse models.
Article
Biochemistry & Molecular Biology
Hee Jung Kim, Yoon Seo Jang, Ji Won Ha, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Kyunga Kim, Ki Hyun Kim, Sung Hee Um
Summary: The compounds isolated from Salix pseudolasiogyne twigs, oregonin and 2'-O-acetylsalicortin, were found to exhibit anti-adipogenic effects, with the latter significantly suppressing lipid accumulation at a concentration of 50 μM. These compounds have the potential to be used as therapeutic agents to effectively control adipocyte differentiation, a critical stage in the progression of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Francesca Molinari, Alessandra Feraco, Simone Mirabilii, Serena Saladini, Luigi Sansone, Enza Vernucci, Giada Tomaselli, Vincenzo Marzolla, Dante Rotili, Matteo A. Russo, Maria Rosaria Ricciardi, Agostino Tafuri, Antonello Mai, Massimiliano Caprio, Marco Tafani, Andrea Armani
Summary: The inhibition of SIRT5 stimulates brown adipogenesis in vitro, promoting the expression of brown adipocyte and mitochondrial markers and increasing lipolysis. This approach shows potential as a strategy to target obesity and type 2 diabetes by activating brown adipose tissue.
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Engineering, Environmental
Yaqiang Cao, Yuanyuan Chen, Ke Miao, Shuyi Zhang, Fuchang Deng, Mu Zhu, Chao Wang, Wen Gu, Yixuan Huang, Zijin Shao, Xiaoyan Dong, Yufeng Gong, Hui Peng, Hui Yang, Yi Wan, Xudong Jia, Song Tang
Summary: Mounting evidence shows the close association between ambient PM2.5 exposure and obesity development, with adipose tissue being an important target. This study employed a preadipocyte differentiation model to comprehensively explore the adipogenic potential of PM2.5. PM2.5 exposure significantly increased fatty acid uptake, lipid accumulation, and adipogenic differentiation in a concentration-dependent manner. Transcriptome and lipidome analyses revealed disruption of transcriptional and lipid profiling at 10 μg/mL PM2.5. Activation of the peroxisome proliferator-activated receptor (PPAR) pathway and metabolism of glycerophospholipids, glycerolipids, and sphingolipids were most affected during adipocyte differentiation. The study demonstrated that PM2.5 promoted adipogenesis by activating PPAR. through reporter gene assays. The findings provide insights into PM2.5-induced adipogenesis and potential biomolecular targets for preventing PM2.5-induced obesity and related metabolic diseases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mi-Jin Oh, Hye-Bin Lee, Guijae Yoo, Miri Park, Chang-Hyun Lee, Inwook Choi, Ho-Young Park
Summary: The study evaluated the anti-obesity effect of water-soluble red pepper leaf extract on adipocytes and HFD-fed mice. The findings showed that the extract reduced fat accumulation and improved intestinal health, suggesting its potential in preventing obesity.
Article
Biotechnology & Applied Microbiology
Chul Sang Lee, Mi Hyun Park, Sae Hun Kim
Summary: This study investigated the potential antiobesity characteristics of six lactic acid bacteria strains on mouse preadipocytes. Lactobacillus johnsonii 3121 and Lactobacillus rhamnosus 86 were found to be effective in reducing triglyceride and lipid accumulation, as well as inhibiting adipocyte differentiation by downregulating adipogenic transcription factors. These results suggest that L. johnsonii 3121 and L. rhamnosus 86 could act as probiotic bacteria to prevent fat accumulation by regulating adipogenesis-related markers.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Medicine, Research & Experimental
Jo Woon Seok, Jae Yeo Park, Hyun Ki Park, Hyangkyu Lee
Summary: Endrin is the most potent obesogen that enhances adipogenesis and promotes early-stage adipogenic differentiation through mTOR pathway activation.
Article
Biochemistry & Molecular Biology
Tae-Jun Park, Anna Park, Jaehoon Kim, Jeong-Yoon Kim, Baek Soo Han, Kyoung-Jin Oh, Eun Woo Lee, Sang Chul Lee, Kwang-Hee Bae, Won Kon Kim
Summary: Obesity is a major health problem linked to metabolic diseases, with adipogenesis being regulated by signals and potentially targeted for obesity prevention through substances like Myonectin.
Article
Biochemistry & Molecular Biology
Mariami Jasaszwili, Tatiana Wojciechowicz, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski
Summary: Neuronostatin activates AKT via GPR107 to promote proliferation of preadipocytes, while inhibiting their differentiation into mature adipocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Chemistry, Medicinal
Hyo-Geun Lee, Yu-An Lu, Jun-Geon Je, Thilina U. Jayawardena, Min-Cheol Kang, Seung-Hong Lee, Tae-Hee Kim, Dae-Sung Lee, Jeong-Min Lee, Mi-Jin Yim, Hyun-Soo Kim, You-Jin Jeon
Summary: The study revealed that ethanol extract from Grateloupia elliptica has a significant inhibitory effect on lipid accumulation, and a chlorophyll derivative with lipid accumulation inhibitory activity was successfully isolated.
Article
Medicine, Research & Experimental
Ji-Su Yoon, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Choe
Summary: This study investigated the role of CypB in 3T3-L1 adipocyte differentiation and found that CypB expression increased during differentiation. Knockdown of CypB delayed cell cycle progression and inhibited adipogenic transcription factors, while overexpression of CypB enhanced cell cycle progression and adipogenic transcription factors. CypB downregulated the expression of CHOP, suggesting an important physiological regulatory role in adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Chemistry, Applied
Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
Article
Food Science & Technology
Eugene Chang, Choon Young Kim
JOURNAL OF FOOD QUALITY
(2018)
Article
Biochemistry & Molecular Biology
Choon Young Kim, Kee-Hong Kim
Review
Immunology
Bonggi Lee, Kyoung Mi Moon, Choon Young Kim
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Chemistry, Applied
Kyoung Mi Moon, Choon Young Kim, Jin Yeul Ma, Bonggi Lee
Article
Integrative & Complementary Medicine
Choon Young Kim, Qi-Ming Yu, Hyun-Joo Kong, Joo-Yeon Lee, Kyung-Mi Yang, Jung-Sook Seo
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Kyoung Mi Moon, Eun-Bin Kwon, Bonggi Lee, Choon Young Kim
Review
Biochemistry & Molecular Biology
Min-Kyeong Lee, Bonggi Lee, Choon Young Kim
Summary: Progress has been made in understanding the developmental lineage and transcriptional factors regulating brown and beige adipocytes, but the role of environmental modifiers such as food components and natural extracts remains unclear. Synthetic drugs targeting adipose tissue browning and thermogenesis produce undesirable pleiotropic effects, highlighting the need for research into alternative natural sources to combat obesity and related metabolic disorders.
Editorial Material
Food Science & Technology
Bonggi Lee, Choon Young Kim
Review
Nutrition & Dietetics
Juhae Kim, Joo-Yeon Lee, Choon Young Kim
Summary: Sarcopenia is a recognized clinical disease characterized by loss of skeletal muscle mass and function associated with aging. Dietary modification, including botanical and marine extracts, phytochemicals, and probiotics, has been shown to be a feasible approach to combat sarcopenia. This review provides an overview of the definition, diagnosis, prevalence, and adverse effects of sarcopenia, explores possible pathological mechanisms, and highlights recent studies on potential biological functions against sarcopenia. The review highlights the importance of further research on dietary materials for healthier aging, particularly in terms of muscle health.
Article
Biochemistry & Molecular Biology
Na-Hyung Kim, Joo-Yeon Lee, Choon Young Kim
Summary: This study investigated the potential improvement effect of the ethanol extract of Cibotium Rhizome (ECR) on dexamethasone-induced muscle atrophy in an in vitro cell model. The study identified the phytochemicals in ECR and found that ECR increased the expression of myosin heavy chain, p-Akt, p-mTOR, p-p70S6K, and repressed the expression of REDD1, KLF15, muscle atrophy F-box, and muscle-specific RING finger protein-1. These findings suggest that further studies are needed to develop therapeutic agents using ECR to alleviate skeletal muscle atrophy or sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Na-Hyung Kim, Juhae Kim, Joo-Yeon Lee, Hyeon-A Bae, Choon Young Kim
Summary: Milk is a nutrient-rich food source, and exosomes derived from milk have shown potential in treating various diseases. However, there is limited research on milk exosomes in relation to geriatric health. This study aims to explore the therapeutic potential of milk exosomes in musculoskeletal diseases, focusing on their cargoes, isolation methods, and recent research in the field. Antioxidant and anti-inflammatory properties of milk exosomes are also discussed.
Article
Food Science & Technology
Juhae Kim, Na-Hyung Kim, Isoo Youn, Eun Kyoung Seo, Choon Young Kim
Summary: The study found that Allium macrostemon Bunge extract can alleviate adipose tissue inflammation and hepatic endoplasmic reticulum stress caused by simultaneous exposure to a high-fat diet and BPA. Further research is needed to determine the specific impact of AM extract supplementation.
Article
Health Care Sciences & Services
Na-Hyung Kim, Choon Young Kim
Summary: This study investigated the association between micronutrient intake and handgrip strength in the Korean older population. The study found that insufficient potassium intake was significantly associated with low handgrip strength, indicating the need for continuous monitoring to intervene or prevent dynapenia or sarcopenia.
