Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Article
Oncology
Wulin Shan, Chunyang Dai, Huanhuan Zhang, Dan Han, Qiyi Yi, Bairong Xia
Summary: This study found that downregulation of ACY1 could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating the Wnt/β-catenin signaling pathway. These findings suggest that ACY1 may serve as a potential radiotherapy target for cetuximab-resistant CRC.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Cell Biology
Xiaolong Tang, Yahang Liang, Guorui Sun, Qingsi He, Hui Qu, Peng Gao
Summary: UBQLN4, a key member of the ubiquitin-like protein family, is upregulated in CRC tissues and associated with tumor size, stage, and metastasis. Its overexpression promotes CRC cell proliferation, migration, and invasion through activation of the Wnt/beta-catenin pathway and C/EBP beta transcriptional activation. Targeting UBQLN4 may hold promise for the diagnosis and treatment of CRC patients.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhongxue Fu
Summary: This study found that Sestrin2 inhibits the progression of colorectal cancer by suppressing cell proliferation, migration, and colony formation. It also affects the cancer stemness properties. This is achieved through downregulation of the Wnt signaling pathway. The findings suggest that Sestrin2 could be a promising therapeutic target for colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Pharmacology & Pharmacy
Xingming Zhao, Zhuo Han, Jiahui Ma, Shiqing Jiang, Xia Li
Summary: The study investigated a novel N-sulfonylamidine derivative 26ag in suppressing CRC cell proliferation and migration, revealing its strong anti-cancer activity by inhibiting C-met and reducing expression of hallmarks associated with EMT, involving the β-catenin-dependent pathway. This research demonstrates the potential of 26ag as a promising drug candidate for the therapy of CRC by inhibiting the Wnt/β-catenin pathway.
Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu
Summary: The study shows that Scutellarin can suppress colitis-associated cancer in mice by inhibiting the Wnt/β-catenin signaling pathway, leading to alleviation of pathological symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongyu Zhou, Chaowei Shang, Min Wang, Tao Shen, Lingmei Kong, Chunlei Yu, Zhennan Ye, Yan Luo, Lei Liu, Yan Li, Shile Huang
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Oncology
Ling-Mei Kong, Tao Feng, Yuan-Yuan Wang, Xing-Yao Li, Zhen-Nan Ye, Tao An, Chen Qing, Xiao-Dong Luo, Yan Li
Article
Oncology
Xiaoli Dong, Jiaxiao Zhang, Zhilin Zhou, Zhennan Ye, Jiahao Chen, Jifan Yuan, Fengjun Cao, Xuanbin Wang, Wenchao Liu, Wenxuan Yu, Xiaohua Li
Article
Cell Biology
Zhennan Ye, Sonnhild Mittag, Martin Schmidt, Andreas Simm, Ruediger Horstkorte, Otmar Huber
Article
Biochemistry & Molecular Biology
Cai-Ling Qiu, Zhen-Nan Ye, Bing-Chao Yan, Kun Hu, Jin Yang, Xing-Zhi Yang, Hong-Mei Li, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno
Summary: Twelve new diterpenoids, together with twenty-eight known ones, have been isolated from the aerial parts of Isodon oresbius. Among them, compound 1 showed cytotoxicity against tumor cells and promoted lysosomal function.
BIOORGANIC CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Lijing Guo, Shihua Chen, Liping Ou, Shangmei Li, Zhen-Nan Ye, Hua-Feng Liu
Summary: Alpha-ketoglutarate (AKG) is a key intermediate in various metabolic pathways, participating in metabolism and signaling pathways. Kidney diseases are linked to metabolic disorders, and recent research focuses on the protective effects of AKG on healthy aging, which provides potential strategies for developing novel therapies.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Min Li, Jun-Hao Wen, Ze-Sen Feng, Yun-Shan Wu, Dong-Yi Li, Shan Liang, Dan Wu, Hong-Luan Wu, Shang-Mei Li, Zhen-Nan Ye, Chen Yang, Lin Sun, Ji-Xin Tang, Hua-Feng Liu
Summary: Transcription factors can affect autophagy activity by promoting or inhibiting the expression of autophagic and lysosomal genes. ZKSCAN3 has been reported as a transcriptional repressor of autophagy, but deficiency of ZKSCAN3 does not induce autophagy or increase lysosomal biogenesis in mice. In this study, ZKSCAN3 knockout cells were generated to investigate its role in the transcriptional regulation of autophagic genes in cancer and non-cancer cells, and it was found that ZKSCAN3 may be a cancer-related gene involved in cancer progression, but not an essential transcriptional repressor of autophagic or lysosomal genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Rong Chen, Li-Jing Guo, Xue-Dan Li, Xing-Ren Li, Kun Hu, Jian-Wei Tang, Zhen-Nan Ye, Bing-Chao Yan, Pema-Tenzin Puno
Summary: Phomopsischalins A (1) and B (2), two novel cytochalasins with unique fused tetracyclic ring systems, and phomopsischalin C (3), featuring a different fused tetracyclic ring system, were obtained from the endophytic fungus Phomopsis sp. shj2. Their structures were determined by various analytical techniques. Compound 2 was found to enhance lysosomal function without involving the transcriptional activity of transcription factor EB (TFEB).
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Medicinal
Zhen-Nan Ye, Mu-Yuan Yu, Ling-Mei Kong, Wei-Hua Wang, Yuan-Feng Yang, Jie-Qing Liu, Ming-Hua Qiu, Yan Li
NATURAL PRODUCTS AND BIOPROSPECTING
(2015)
Article
Chemistry, Medicinal
Jing Zhang, Ling-Mei Kong, Rui Zhan, Zhen-Nan Ye, Jian-Xin Pu, Han-Dong Sun, Yan Li
NATURAL PRODUCTS AND BIOPROSPECTING
(2014)
Article
Cell Biology
X. Li, B. Bai, L. Liu, P. Ma, L. Kong, J. Yan, J. Zhang, Z. Ye, H. Zhou, B. Mao, H. Zhu, Y. Li
CELL DEATH DISCOVERY
(2015)