Article
Chemistry, Multidisciplinary
Yumin Kang, Abhinav Goyal, Sangmun Hwang, Cheonho Park, Hyun U. Cho, Hojin Shin, Jinsick Park, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Dong Pyo Jang
Summary: FSCV is a technique for measuring neurotransmitter release with millisecond temporal resolution, capable of measuring concentrations down to the nanomolar scale. By optimizing the technique, the detection limit of FSCV can be further lowered.
Article
Chemistry, Multidisciplinary
Mimi Shin, B. Jill Venton
Summary: In this study, we developed fast-scan cyclic voltammetry (FSCV) to measure dopamine release in fruit flies during behavior. The results showed that sugar feeding induced longer dopamine release compared to acetylcholine stimulation in the mushroom body. In addition, administering dopamine transporter inhibitor or D2 receptor antagonist significantly increased sugar-evoked dopamine release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Romana Jarosova, Adam D. Douglass, Michael A. Johnson
Summary: In this study, a waveform for the measurement of oxytocin was optimized using carbon-fiber microelectrodes and flow injection analysis. The method achieved a low limit of quantitation and was successfully applied to measure oxytocin release in the brains of genetically engineered zebrafish.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Elisa Castagnola, Elaine M. Robbins, Bingchen Wu, May Yoon Pwint, Raghav Garg, Tzahi Cohen-Karni, Xinyan Tracy Cui
Summary: Dopamine plays a central role in various physiological brain functions. Current detection technologies for dopamine have limitations in spatial and temporal resolution, channel count, longitudinal stability, and ability to measure both phasic and tonic dynamics. This study presents an implantable glassy carbon multielectrode array for integrated multichannel measurements of dopamine concentrations.
Review
Cell Biology
Vladimir P. Grinevich, Amir N. Zakirov, Uliana V. Berseneva, Elena V. Gerasimova, Raul R. Gainetdinov, Evgeny A. Budygin
Summary: Fast-scan cyclic voltammetry (FSCV) is a technique used for real-time monitoring of neurotransmitter dynamics, which has significant implications in the study of neuropsychiatric disorders.
Article
Biochemical Research Methods
Noel Manring, Muzammil M. N. Ahmed, Jessica L. Smeltz, Pavithra Pathirathna
Summary: The etiology of neurodegenerative diseases is poorly understood and the heavy metal copper has been found to play a critical role in neurotoxicity, affecting the development of these diseases. Analyzing heavy metals in the brain is challenging due to the limitations of existing metal detection tools, resulting in inadequate data for developing efficient therapeutics. This study developed a surface-modified electrode using fast-scan cyclic voltammetry to detect ultra-low concentrations of copper in the brain accurately and in real time.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Electrochemistry
Favian A. Liu, Negar Ardabili, Izaiah Brown, Harmain Rafi, Clarice Cook, Rodanthi Nikopoulou, Arianna Lopez, Shouzhong Zou, Matthew R. Hartings, Alexander G. Zestos
Summary: Carbon fiber microelectrodes have been used to detect neurotransmitters and biomolecules. This study demonstrates the use of the Modified Sawhorse Waveform for measuring tyrosine and oxytocin, and shows that it can be used for real-time measurements of exogenously applied oxytocin on rat brain slices.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jaekyung Kim, Abhijeet S. Barath, Aaron E. Rusheen, Juan M. Rojas Cabrera, J. Blair Price, Hojin Shin, Abhinav Goyal, Jason W. Yuen, Danielle E. Jondal, Charles D. Blaha, Kendall H. Lee, Dong Pyo Jang, Yoonbae Oh
Summary: This study developed a computational technique using a statistical model for standardized, unbiased analysis of experimental MCSWV data for unbiased quantification of tonic DA. The technique showed reliable and improved estimation of tonic DA levels in vivo compared to conventional manual post-processing methods.
Article
Biochemistry & Molecular Biology
Rohan Bhimani, Ryan Yates, Caroline E. Bass, Jinwoo Park
Summary: The olfactory tubercle (OT) is an important brain region involved in the integration of reward-related information, with its subregions showing different roles in dopamine regulation. Studies have found that VTA-DA regulation in the medial OT is less dependent on dopamine transporters and has greater dopamine transmission than the lateral OT.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Michelle Hadad, Nadine Hadad, Alexander G. Zestos
Summary: In this study, a method for measuring cortisol using carbon fiber microelectrodes and fast-scan cyclic voltammetry was developed. This method showed high sensitivity, high spatiotemporal resolution, and biocompatibility, and it was able to detect cortisol stably. Its application will contribute to a better understanding of the physiological importance of cortisol.
Article
Biochemistry & Molecular Biology
Anna C. Everett, Ben E. Graul, Joakim W. Ronstrom, J. Kayden Robinson, Daniel B. Watts, Rodrigo A. Espana, Cody A. Siciliano, Jordan T. Yorgason
Summary: This study presents an alternative approach for measuring and distinguishing dopamine release from clearance using the first derivative of evoked dopamine signals. The maximal upward velocity predicts reductions in dopamine peak height, while the Michaelis-Menten maximal velocity measure predicts maximal downward velocity. Various measures can be used to assess dopamine release and clearance based on the experimental results.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Edoardo Cuniberto, Zhujun Huang, Michael D. Ward, Davood Shahrjerdi
Summary: Fast-scan cyclic voltammetry (FSCV) with micron-sized carbon sensors is a promising method for monitoring serotonin (5-HT) neuromodulatory signals in the brain. However, the complex chemical reactions associated with 5-HT can compromise sensor performance. This study used engineered graphitic sensors to characterize the electrochemistry of 5-HT and optimize the FSCV conditions for quantitative in vivo detection. The results revealed the significant role of water in driving side reactions and provided new insights for more reliable 5-HT detection.
Article
Chemistry, Physical
Rui Xia, Kangning Zhao, Jie Zheng, Tao Shen, Lei Zhang, Mark Huijben, Johan ten Elshof
Summary: Fast charging performance of electrode materials is crucial for batteries in portable devices and electric vehicles. This study proposes a new theoretical framework that can decouple the impacts of ohmic resistance, reaction rate, and ion diffusion on the fast charging properties of electrodes. The model is successfully validated using cyclic voltammetry data of four typical electrode materials. Surprisingly, it is found that the reaction rate is the limiting factor for the fast charging performance in all materials analyzed. The new model is believed to facilitate electrode design and accelerate the development of the next generations of fast-charging batteries.
ENERGY STORAGE MATERIALS
(2022)
Article
Biophysics
Elisa Castagnola, Raghav Garg, Sahil K. Rastogi, Tzahi Cohen-Karni, Xinyan Tracy Cui
Summary: The newly developed three-dimensional fuzzy graphene microelectrode arrays show high sensitivity and stability for dopamine detection, enabling multi-site detection in the brain and potentially improving treatments and understanding of neurological disorders.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Electrochemistry
Chase Stucky, Michael A. Johnson
Summary: In this study, it was found that three different SSRIs significantly decrease the oxidation current of serotonin when using the commonly used Jackson waveform. Coating carbon-fiber microelectrodes with Nafion further reduces the current and increases response times. To address fouling issues, an extended serotonin waveform was used, which alleviated the decrease in current, indicating reduced electrode fouling.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Clinical Neurology
Burcu Zeydan, Christopher G. Schwarz, Val J. Lowe, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Walter K. Kremers, Matthew L. Senjem, Jeffrey L. Gunter, Hoon-Ki Min, Prashanthi Vemuri, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Orhun H. Kantarci, Kejal Kantarci
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2019)
Article
Neurosciences
Jeyeon Lee, Hang Joon Jo, Lnyong Kim, Jihyun Lee, Hoon-Ki Min, Myung-Ho In, Emily J. Knight, Su-Youne Chang
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Clinical Neurology
Zeynep Idil Seckin, Jennifer L. Whitwell, Rene L. Utianski, Hugo Botha, Farwa Ali, Joseph R. Duffy, Heather M. Clark, Mary M. Machulda, Lennon G. Jordan, Hoon-Ki Min, Val J. Lowe, Keith A. Josephs
JOURNAL OF NEUROLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela D. Maltais, Lennon G. Jordan, Hoon-Ki Min, Toji Miyagawa, Scott A. Przybelski, Timothy G. Lesnick, Robert R. Reichard, Dennis W. Dickson, Melissa E. Murray, Kejal Kantarci, Bradley F. Boeve, Val J. Lowe
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Shinho Cho, Hoon-Ki Min, Myung-Ho In, Hang Joon Jo
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Julia P. Slopsema, Antonietta Canna, Michelle Uchenik, Lauri J. Lehto, Jordan Krieg, Lucius Wilmerding, Dee M. Koski, Naoharu Kobayashi, Joan Dao, Madeline Blumenfeld, Pavel Filip, Hoon-Ki Min, Silvia Mangia, Matthew D. Johnson, Shalom Michaeli
Summary: This study investigated the effects of direction and orientation of the electric field induced by VL-thalamus DBS on activity in the sensorimotor cortex using a swine animal model. Results showed that directional and orientation-selective stimulation could tune network-level modulation patterns in the sensorimotor cortex.
Article
Clinical Neurology
Qin Chen, Val J. Lowe, Bradley F. Boeve, Scott A. Przybelski, Toji Miyagawa, Matthew L. Senjem, Clifford R. Jack, Timothy G. Lesnick, Walter K. Kremers, Julie A. Fields, Hoon-Ki Min, Christopher G. Schwarz, Jeffrey L. Gunter, Jonathan Graff-Radford, Rodolfo Savica, David S. Knopman, David Jones, Tanis J. Ferman, Neill R. Graff-Radford, Ronald C. Petersen, Kejal Kantarci
Summary: The majority of patients with MCI-LB are characterized by low beta-amyloid deposition and reduced dopaminergic activity, and beta-amyloid PET and 123I-FP-CIT SPECT are complementary in characterizing clinical phenotypes of patients with MCI-LB.
Article
Geriatrics & Gerontology
Toji Miyagawa, Scott A. Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G. Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica, David Knopman, Ronald Petersen, Walter K. Kremers, Leah K. Forsberg, Julie A. Fields, Tanis J. Ferman, Laura Allen, Joseph Parisi, R. Ross Reichard, Melissa Murray, Dennis Dickson, Bradley F. Boeve, Kejal Kantarci, Val J. Lowe
Summary: Multimodal imaging with I-123-FP-CIT SPECT helps differentiate DLBs and ADem, providing additional diagnostic value and detecting complex pathology in patients with DLBs and ADem.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
William S. Gibson, Aaron E. Rusheen, Yoonbae Oh, Myung-Ho In, Krzysztof R. Gorny, Joel P. Felmlee, Bryan T. Klassen, Sung Jun Jung, Hoon-Ki Min, Kendall H. Lee, Hang Joon Jo
Summary: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD) motor symptoms, but does not always yield optimal outcomes. Combining intraoperative functional MRI (fMRI) with DBS revealed activation patterns predictive of therapeutic and adverse effects, potentially guiding clinical stimulator optimization for patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Burcu Zeydan, Christopher G. Schwarz, Scott A. Przybelski, Timothy G. Lesnick, Walter K. Kremers, Matthew L. Senjem, Orhun H. Kantarci, Paul H. Min, Bradley J. Kemp, Clifford R. Jack, Kejal Kantarci, Val J. Lowe
Summary: This study investigates the use of PET imaging techniques for assessing white matter integrity and demyelination. The results show that both 11C-PiB and 18F-flutemetamol can effectively differentiate between white matter hyperintensities and normal-appearing white matter, and their uptake patterns are associated with age.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemical Research Methods
Jillissa C. Taubel, Nicholas R. Nelson, Aditya Bansal, Geoffrey L. Curran, Lushan Wang, Zengtao Wang, Heather M. Berg, Cynthia J. Vernon, Hoon-Ki Min, Nicholas B. Larson, Timothy R. DeGrado, Karunya K. Kandimalla, Val J. Lowe, Mukesh K. Pandey
Summary: Aberrant insulin signaling has been identified as a risk factor for Alzheimer's disease. A new positron emission tomography (PET) probe has been developed to study the role of insulin in Alzheimer's disease noninvasively. The PET probe showed higher uptake in the brains of Alzheimer's disease mice compared to normal mice. It also demonstrated differential uptake in different brain regions.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeyeon Lee, Brian J. Burkett, Hoon-Ki Min, Emily S. Lundt, Sabrina M. Albertson, Hugo Botha, Matthew L. Senjem, Jeffrey L. Gunter, Christopher G. Schwarz, David T. Jones, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Val J. Lowe
Summary: In tau PET scans, identifying voxels with stable activity over time can enhance detection of early tau accumulation. The overlap index (OI) method shows improved sensitivity to tau signal elevation in low-SUV regions and is associated with early clinical disease progression and cognitive scores.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neuroimaging
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Migayawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe
Summary: Patients with mild cognitive impairment (MCI) who progressed to probable dementia with Lewy bodies (DLB) show hypometabolism in the parieto-occipital cortex extending into temporal lobes, substantia nigra, and thalamus. In comparison to those who progressed to Alzheimer's disease (AD) dementia, MCI-DLB patients exhibit preserved medial temporal and posterior cingulate metabolism, along with greater hypometabolism in the substantia nigra. The CIS ratio and medial temporal to substantia nigra ratio are identified as useful in distinguishing prodromal DLB from AD.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Abhijeet S. Barath, Aaron E. Rusheen, Hoon-Ki Min, Jeyeon Lee, Erika Ross, Sooyoon Shin, Adam Loudermilk, Bambi Wessel, Val J. Lowe, Kendal H. Lee, Charles D. Blaha
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2020)
Meeting Abstract
Clinical Neurology
Zeynep Idil Seckin, Jennifer Whitwell, Rene Utianski, Hugo Botha, Farwa Ali, Joseph Duffy, Heather Clark, Mary Machulda, Lennon Jordan, Val Lowe, Keith Josephs