Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme

Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells

(2017) Xuewen Liu et al.   ONCOLOGY REPORTS

MicroRNA-92b inhibits epithelial-mesenchymal transition-induced migration and invasion by targeting Smad3 in nasopharyngeal cancer

(2017) Chong Zhao et al.   Oncotarget

Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/Adriamycin cells

(2016) Fen Cai et al.   ONCOLOGY REPORTS

Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction

(2016) Guangwen Shu et al.   Oncotarget

HDAC1 controls CIP2A transcription in human colorectal cancer cells

(2016) Manjola Balliu et al.   Oncotarget

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines

(2015) AS Yar Saglam et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers

(2015) Anchit Khanna et al.   INTERNATIONAL JOURNAL OF CANCER

Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B

(2015) Fardous F. El-Senduny et al.   TUMOR BIOLOGY

Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer

(2015) Bo Zhang et al.   Oncotarget

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

(2015) Seth A. Brodie et al.   Oncotarget

PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

(2015) Raúl Rincón et al.   Oncotarget

Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells

(2015) Wei Cao et al.   Scientific Reports

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

(2015) Peng Lv et al.   Oncotarget

Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A

(2014) H-C Yu et al.   Cell Death & Disease

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

(2013) Zi Liu et al.   CARCINOGENESIS

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

International Myeloma Working Group recommendations for global myeloma care

(2013) H Ludwig et al.   LEUKEMIA

Expression and biological role of CIP2A in human astrocytoma

(2013) FUXIN YI et al.   Molecular Medicine Reports

Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells

(2013) YING LIU et al.   Oncology Letters

Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells

(2012) C.-Y. Liu et al.   HAEMATOLOGICA

AKT as locus of cancer multidrug resistance and fragility

(2012) Ziv Radisavljevic   JOURNAL OF CELLULAR PHYSIOLOGY

Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients’ survival

(2011) J Ren et al.   BRITISH JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells

(2010) Chu-Chung Chou et al.   ARCHIVES OF PHARMACAL RESEARCH

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

(2010) Kin Tak Chan et al.   CANCER LETTERS

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

CIP2A Is Associated with Human Breast Cancer Aggressivity

(2009) C. Come et al.   CLINICAL CANCER RESEARCH

CIP2A Is Overexpressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence, or Differentiation of Tumor Cells

(2008) W. Li et al.   CLINICAL CANCER RESEARCH