Article
Plant Sciences
Ruiting Han, Huihui Qiu, Jing Zhong, Ningning Zheng, Bingbing Li, Ying Hong, Junli Ma, Gaosong Wu, Linlin Chen, Lili Sheng, Houkai Li
Summary: Si Miao Formula (SMF) alleviated HFHS diet-induced NAFLD in mice by reducing hepatic steatosis, body weight gain, and improving insulin sensitivity and glucose tolerance. SMF downregulated fatty acid biosynthesis and stimulated the insulin secretion pathway in the liver, while also altering gut microbiota composition, particularly increasing the abundance of Akkermansia muciniphila. These findings indicate that SMF possesses potential anti-NAFLD effects through modulation of hepatic lipid metabolism pathways and gut microbiota composition.
Article
Biochemistry & Molecular Biology
Li Zhang, Youjie Wang, Fei Wu, Xu Wang, Yi Feng, Yuan Wang
Summary: MDG, derived from Ophiopogon japonicus, has a protective effect against obesity and nonalcoholic fatty liver disease (NAFLD). This study found that MDG supplementation improved lipid accumulation, liver steatosis, and chronic inflammation in NAFLD mice induced by a high-fat diet. It also increased the abundance and diversity of gut microbial communities. The results suggest that MDG treatment can inhibit obesity and the NAFLD process by modulating lipid-related pathways and altering the structure and diversity of gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Pei-Hsuan Chen, Yi-Huei Lai, Hsin-Yu Shih, Wen-Chih Huang, Hsin-Yi Yang
Summary: This study found that dietary dehulled adlay can prevent the progression of alcoholic liver disease by reducing hepatic oxidative stress and inflammation, and modulating gut dysbiosis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Moon Ho Do, Hyun Hee L. Lee, Yoonsook Kim, Hye-Bin Lee, Eunjung Lee, Jae Ho Park, Ho-Young Park
Summary: This study suggests that water-soluble extract from molokhia (WM) can alleviate alcohol-induced liver damage by improving gut microbial composition and gut barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Gastroenterology & Hepatology
Oliver Pabst, Mathias W. Hornef, Frank G. Schaap, Vuk Cerovic, Thomas Clavel, Tony Bruns
Summary: In this review, the gut-liver axis is discussed, focusing on the barriers formed by the enterohepatic tissues to restrict gut-derived microorganisms, microbial stimuli and dietary constituents. The establishment and regulation of structural and functional barriers, dynamics within the axis (immune responses and microbiome), and clinical implications are also highlighted.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Food Science & Technology
Namhee Kim, Jieun Lee, Hye Seon Song, Young Joon Oh, Min-Sung Kwon, Misun Yun, Seul Ki Lim, Hyo Kyeong Park, Young Seo Jang, Sulhee Lee, Sang-Pil Choi, Seong Woon Roh, Hak-Jong Choi
Summary: This study found that kimchi can suppress obesity-induced inflammation and exert its effects by changing gut microbiota composition and short-chain fatty acids production.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Qianqian Yao, Yanan Gao, Linlin Fan, Jiaqi Wang, Nan Zheng
Summary: This study aimed to investigate the alleviating effect of 2'-fucosyllactose (2'-FL) on colitis-induced liver injury and its mechanism of influencing metabolism by regulating gut microbiota. The results showed that 2'-FL could improve liver oxygen stress in colitis mice and regulate gut microbiota and metabolites, especially glycometabolism and lipid-metabolism-related metabolites, thereby alleviating liver oxygen stress.
Article
Food Science & Technology
Hailong Li, Ziyang Xie, Yao Zhang, Yue Liu, Aijing Niu, Yingying Liu, Linbo Zhang, Lili Guan
Summary: The study found that polysaccharide from Rosa rugosa (RRP) has a significant protective effect on acute alcoholic liver disease (ALD), by regulating liver function and balancing gut microbiota, providing theoretical basis for the development of natural liver-protecting drugs.
Article
Gastroenterology & Hepatology
Thomas Henry Tranah, Lindsey A. Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Summary: Cirrhotic portal hypertension is characterized by the development of serious complications such as ascites, encephalopathy, bleeding, and hepatorenal syndrome, which are often caused by cirrhosis-associated immune dysfunction. Bacterial infections are common complications of chronic liver disease and are closely linked to dysbiosis of the intestinal microbiota.
Review
Microbiology
Yiming Ni, Mengna Lu, Yuan Xu, Qixue Wang, Xinyi Gu, Ying Li, Tongxi Zhuang, Chenyi Xia, Ting Zhang, Xiao-jun Gou, Mingmei Zhou
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing global health problem with suboptimal treatments. Bile acids and gut microbiota play crucial roles in the pathogenesis of NAFLD, and investigating these factors may aid in the development of novel drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yong Rao, Zhiqi Kuang, Chan Li, Shiyao Guo, Yaohao Xu, Dandan Zhao, Yutao Hu, Bingbing Song, Zhi Jiang, Zhenhuang Ge, Xiyuan Liu, Chengdao Li, Shuobin Chen, Jiming Ye, Zhishu Huang, Yongjun Lu
Summary: Akkermansia muciniphila has therapeutic potential in treating metabolic disorders such as NAFLD, with mechanisms involving increased mitochondrial oxidation, bile acid metabolism, and reshaping of gut microbiota composition. Additionally, the regulation of L-aspartate metabolism contributes to the beneficial effects on MAFLD.
Article
Biochemistry & Molecular Biology
Cheng Fang, Jinyan Cheng, Wei Jia, Yan Xu
Summary: This study investigated the impact of Akkermansia muciniphila on alcoholic liver disease (ALD) using a mouse model. The results showed that oral administration of A. muciniphila alleviated alcohol-induced liver injury, altered serum metabolomic profiles, and regulated gut microbiota composition. These findings provide a theoretical basis for the development of A. muciniphila as a potential therapeutic approach for preventing and managing ALD.
Article
Engineering, Environmental
Peng Zhang, Liyang Zheng, Yitao Duan, Yuting Gao, Huihui Gao, Daqing Mao, Yi Luo
Summary: The study revealed that TCS can cause liver injury by disturbing lipid metabolism and dysbiosis of gut microbiota. TCS also increases intestinal permeability, contributing to liver damage. The research provides new insights into the health impact of TCS on the human body.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Thananya Jinato, Maneerat Chayanupatkul, Thasinas Dissayabutra, Anuchit Chutaputti, Pisit Tangkijvanich, Natthaya Chuaypen
Summary: This study provides evidence that oligonol improves liver steatosis by modulating gut bacterial composition, suggesting its potential therapeutic role in treating non-alcoholic fatty liver disease (NAFLD).
Review
Biochemistry & Molecular Biology
Maria Del Barrio, Lucia Lavin, Alvaro Santos-Laso, Maria Teresa Arias-Loste, Aitor Odriozola, Juan Carlos Rodriguez-Duque, Coral Rivas, Paula Iruzubieta, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) currently. Lifestyle change is the only available therapeutic recommendation, but adherence to this approach is often challenging. Manipulation of the microbiota and improving intestinal permeability may offer promising therapeutic strategies for NAFLD. Faecal microbiota transplantation (FMT) is a potential method to achieve this. In this review, we summarize key aspects of FMT, discuss its current indications, and highlight recent advances in NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Sergio Maroto-Izquierdo, Kazunori Nosaka, Anthony J. Blazevich, Javier Gonzalez-Gallego, Jose A. de Paz
Summary: The study investigated the effects of three different unilateral isoinertial resistance training protocols with eccentric overload on changes in lean mass and muscle function of trained and contralateral non-trained legs. The results showed that all training groups in the trained legs experienced increases in strength, lean tissue mass, muscle power, and vertical jump height, while in the non-trained legs, significant increases in strength and lean mass were observed in the EM150 and FW groups. Overall, the eccentric-overload resistance training modalities induced strong cross-education effects in both trained and non-trained legs.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Review
Cell Biology
Beatriz San-Miguel, Paula Fernandez-Palanca, Jose L. Mauriz, Maria J. Tunon, Javier Gonzalez-Gallego
Summary: Melatonin has shown beneficial effects in liver fibrosis, by reducing profibrogenic markers, modulating cellular processes and molecular pathways, acting as an antioxidant and anti-inflammatory agent. It has the potential to ameliorate the development and progression of liver fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Maria Crespo-Masip, Aurora Perez-Gomez, Alicia Garcia-Carrasco, Ramiro Jover, Carla Guzman, Xavier Dolcet, Merce Ibarz, Cristina Martinez, Auria Eritja, Juan Miguel Diaz-Tocados, Jose Manuel Valdivielso
Summary: This study found that lack of vitamin D signaling increases mortality in a model of overactivation of the insulin receptor by impairing lipid metabolism. These findings highlight the importance of adequate vitamin D levels in patients with type 1 diabetes.
Article
Endocrinology & Metabolism
Maria Crespo-Masip, Aurora Perez-Gomez, Carla Guzman, Sandra Rayego, Nuria Dolade, Alicia Garcia-Carrasco, Ramiro Jover, Jose Manuel Valdivielso
Summary: In this study, we generated PTEN-KO mice to investigate the systemic effect of overactivation of the PI3K/AKT pathway on insulin signaling and glucose homeostasis. Our findings suggest that PTEN deficiency leads to abnormal glucose metabolism and insulin signaling, characterized by low glucose levels and impaired response to glucose and pyruvate administration. We also identified deregulation of glucose transporter expression in the proximal tubule and altered activation of hepatic gluconeogenesis-related genes in PTEN-KO mice. These results indicate that PTEN may play a crucial role in hypoinsulinemic hypoglycemia and could serve as a potential drug target.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Maria Juarez-Fernandez, Naroa Goikoetxea-Usandizaga, David Porras, Maria Victoria Garcia-Mediavilla, Miren Bravo, Marina Serrano-Macia, Jorge Simon, Teresa C. Delgado, Sofia Lachiondo-Ortega, Susana Martinez-Florez, Oscar Lorenzo, Mercedes Rincon, Marta Varela-Rey, Leticia Abecia, Hector Rodriguez, Juan Anguita, Esther Nistal, Maria Luz Martinez-Chantar, Sonia Sanchez-Campos
Summary: This study provides evidence for the relevance of the interaction between mitochondria and microbiota in NASH and identifies targeting this interaction as a valuable therapeutic approach.
Review
Oncology
Paula Fernandez-Palanca, Tania Payo-Serafin, Flavia Fondevila, Carolina Mendez-Blanco, Beatriz San-Miguel, Marta R. Romero, Maria J. Tunon, Jose J. G. Marin, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: This study evaluated the prognostic, diagnostic and clinicopathological value of NRP1 in liver cancer and CRC patients, showing that NRP1 overexpression is significantly correlated with lower survival and tumor development, suggesting NRP1 may be a potential and useful biomarker in both types of cancer.
Review
Oncology
Jose J. G. Marin, Maria J. Monte, Rocio I. R. Macias, Marta R. Romero, Elisa Herraez, Maitane Asensio, Sara Ortiz-Rivero, Candela Cives-Losada, Silvia Di Giacomo, Javier Gonzalez-Gallego, Jose L. Mauriz, Thomas Efferth, Oscar Briz
Summary: Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the approximately 10 million cancer-related deaths worldwide each year. One primary reason for this high mortality is the lack of response of these cancers to pharmacological treatment. More than 100 genes have been identified as responsible for seven mechanisms of chemoresistance, but only a few play a critical role, including ABC proteins (mainly MDR1, MRP1-6, and BCRP), whose expression pattern greatly determines individual tumor sensitivity to pharmacotherapy.
Review
Nutrition & Dietetics
Brisamar Estebanez, Chun-Jung Huang, Marta Rivera-Viloria, Javier Gonzalez-Gallego, Maria J. Cuevas
Summary: Childhood obesity is a major public health issue that increases the risk for cardiometabolic diseases and related complications in adulthood. Inflammation and oxidative stress are identified as the primary mechanisms underlying obesity-related diseases. Physical activity has consistently been shown to improve obesity-mediated inflammation and oxidative stress status.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Paula Fernandez-Palanca, Tania Payo-Serafin, Beatriz San-Miguel, Carolina Mendez-Blanco, Maria J. Tunon, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: Despite pharmacological advances, therapeutic failure in hepatocellular carcinoma (HCC) remains a challenge due to its complex molecular mechanisms. This study investigates the interplay among neuropilin-1 (NRP1), autophagy, and hypoxia in the development of lenvatinib resistance in HCC cell lines. The results show that NRP1 is significantly increased in HCC samples and correlated with advanced tumor and metastasis stages. Additionally, NRP1 silencing enhances the anticancer effects of lenvatinib, and hypoxia-induced autophagy further enhances lenvatinib's effectiveness through HIF-1 alpha modulation.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Gastroenterology & Hepatology
Paula Fernandez-Palanca, Tania Payo-Serafin, Carolina Mendez-Blanco, Beatriz San-Miguel, Maria J. Tunon, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: This study systematically reviews the role of neuropilins (NRPs) NRP1 and NRP2 in hepatocellular carcinoma (HCC). The findings suggest that NRPs are potential biomarkers for diagnosis and prognosis in HCC patients, as they are involved in multiple cellular and molecular processes associated with tumor progression. NRPs mainly regulate angiogenesis, invasion, migration, immune response, tumor microenvironment, and interplay with hypoxia response and microRNAs in HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Brisamar Estebanez, Francisco J. Amaro-Gahete, Cristina Gil-Gonzalez, Javier Gonzalez-Gallego, Maria J. Cuevas, David Jimenez-Pavon
Summary: Exosome release is influenced by the physiological state of the cell and may play a significant role in obesity. Exercise-induced exosomes may contribute to the beneficial effects of physical activity on weight and cardiovascular parameters. This study investigated the impact of a 12-week concurrent training intervention on exosome cargo modifications in obese men and explored the relationship between changes in exosomes and cardiometabolic health parameters. Although no significant changes in exosomal markers and proteins were observed, there were associations between certain proteins (CD81, Flot-1, HSP70, CD14) and various health parameters. The findings suggest a potential relationship between exosome-carried proteins and obesity treatment.
Meeting Abstract
Gastroenterology & Hepatology
Maria Juarez-Fernandez, Naroa Goikoetxea, David Porras, Maria-Victoria Garcia-Mediavilla, Hector Rodriguez, Esther Nistal, Susana Martinez-Florez, Mercedes Rincon, Marta Varela-Rey, Javier Gonzalez-Gallego, Leticia Abecia, Juan Anguita, Maria Luz Martinez-Chantar, Sonia Sanchez-Campos
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Paula Fernandez-Palanca, Tania Payo-Serafin, Flavia Fondevila, Carolina Mendez-Blanco, Javier Gonzalez-Gallego, Jose Luis Mauriz
JOURNAL OF HEPATOLOGY
(2022)
