Impaired Pentose Phosphate Pathway in the Spinal Cord of the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2018) Tesfaye W Tefera et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

(2018) Kah Ni Tan et al.   JOURNAL OF NEUROCHEMISTRY

Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells

(2018) Tong Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Drug therapy: On the treatment trail for ALS

(2017) Andrew Scott   NATURE

Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments

(2017) Tesfaye W. Tefera et al.   Frontiers in Neuroscience

Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis

(2016) Tesfaye W. Tefera et al.   NEUROCHEMICAL RESEARCH

Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Tesfaye W. Tefera et al.   PLoS One

Disruption of TCA Cycle and Glutamate Metabolism Identified by Metabolomics in an In Vitro Model of Amyotrophic Lateral Sclerosis

(2015) Charlotte Veyrat-Durebex et al.   MOLECULAR NEUROBIOLOGY

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

A liquid chromatography–tandem mass spectrometry-based investigation of the lamellar interstitial metabolome in healthy horses and during experimental laminitis induction

(2015) C.E. Medina-Torres et al.   VETERINARY JOURNAL

Role of Energy Metabolic Deficits and Oxidative Stress in Excitotoxic Spinal Motor Neuron Degeneration in Vivo

(2014) Luz Diana Santa-Cruz et al.   ASN Neuro

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

(2014) Ernesto Miquel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model

(2014) Csilla Ari et al.   PLoS One

Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options

(2013) Sonja Körner et al.   BMC Neurology

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

(2013) J. C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

(2012) Wei Zhao et al.   PLoS One

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   BRAIN

Early and Progressive Impairment of Spinal Blood Flow—Glucose Metabolism Coupling in Motor Neuron Degeneration of ALS Model Mice

(2011) Kazunori Miyazaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

(2011) Giuseppina D'Alessandro et al.   NEUROBIOLOGY OF DISEASE

Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1G93A mice model

(2011) Marcelo R. Vargas et al.   NEUROBIOLOGY OF DISEASE

Transcriptional Profiling in the Lumbar Spinal Cord of a Mouse Model of Amyotrophic Lateral Sclerosis: A Role for Wild-Type Superoxide Dismutase 1 in Sporadic Disease?

(2010) Antonello D’Arrigo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Oxidative stress biomarkers in sporadic ALS

(2008) Hiroshi Mitsumoto et al.   Amyotrophic Lateral Sclerosis

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE