Article
Neurosciences
Shiheng Lu, Hui Wang, Jian Zhang
Summary: In this study, advanced machine learning methods were used to identify key functions and biological processes related to uveitis, providing a theoretical foundation for the clinical treatment of the disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Yusaku Tsugami, Sayaka Nakayama, Naoki Suzuki, Takahiro Nii, Naoki Isobe
Summary: This study found that the mammary glands of lactating goats contain ectopic tertiary lymphoid organs (TLOs) which contribute to local immunity by producing immunoglobulins.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amit Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Tertiary lymphoid organs (TLOs) are immune cell collections that form in non-lymphoid tissues in response to local chronic inflammation. They have complex structures and can generate strong immune responses at sites of tissue injury. Despite our improved understanding of TLO formation and function, their role in chronic inflammatory diseases remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Eva Korpos, Nadir Kadri, Sophie Loismann, Clais R. Findeisen, Frank Arfuso, George W. Burke, Sarah J. Richardson, Noel G. Morgan, Marika Bogdani, Alberto Pugliese, Lydia Sorokin
Summary: TLOs were found in the pancreas of individuals with type 1 diabetes, showing similarities with TLOs in NOD mouse pancreases. These TLOs may play a crucial role in autoimmune processes, especially in relation to insulin-containing islets, with their frequency decreasing as beta cell loss severity increases.
Review
Medicine, Research & Experimental
Sathish Paramasivan, Alkis J. Psaltis, Peter-John Wormald, Sarah Vreugde
Summary: This review outlines the role of tertiary lymphoid organs in ENT diseases, summarizing early findings in the areas of oral squamous cell carcinoma and chronic rhinosinusitis. While research suggests significant roles of TLOs in ENT diseases, they remain somewhat of a mystery among otolaryngologists. As research in this field progresses, a better understanding of how lymphoid neogenesis can impact disease outcomes and potential immunotherapeutic uses may be gained.
Article
Biochemical Research Methods
Erik Huckvale, Hunter N. B. Moseley
Summary: Researchers have developed a Python package called kegg_pull that provides improved access and utilization of the KEGG database. It includes both an API and a command line interface, allowing users to download and save an arbitrary number of KEGG entries. The package also offers efficient utilization of multiple CPU cores and provides recommendations for optimal usage based on network and computational circumstances.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Susanne Fleig, Tamar Kapanadze, Jeremiah Bernier-Latmani, Julia K. Lill, Tania Wyss, Jaba Gamrekelashvili, Dustin Kijas, Bin Liu, Anne M. Huesing, Esther Bovay, Adan Chari Jirmo, Stephan Halle, Melanie Ricke-Hoch, Ralf H. Adams, Daniel R. Engel, Sibylle von Vietinghoff, Reinhold Foerster, Denise Hilfiker-Kleiner, Hermann Haller, Tatiana Petrova, Florian P. Limbourg
Summary: Loss of endothelial Notch signaling in adult mice leads to spontaneous formation of bona fide TLS in non-lymphoid organs like the kidney, liver, and lung. These TLS form around parenchymal arteries and involve loss of arterial specification and acquisition of a high endothelial cell phenotype.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Ran Luo, Yichun Cheng, Dan Chang, Tingting Liu, Liu Liu, Guangchang Pei, Nanhui Zhang, Zufeng Wang, Kanglin Guo, Wei Chen, Ming Li, Li Fan, Chunxiu Zhang, Yueqiang Li, Wei Dai, Meiying Zuo, Yulin Xu, Ying Yao, Shuwang Ge, Gang Xu
Summary: Renal TLOs are associated with the severity of IgA nephropathy and serve as independent risk factors for disease progression. Inhibiting the formation of renal TLOs can reduce intrarenal inflammation and fibrosis, with early intervention being more effective. IL-17A plays a role in the formation of renal TLOs, and genetic depletion or treatment with anti-IL-17A antibody can reduce TLOs formation and alleviate renal inflammation and fibrosis.
Article
Food Science & Technology
Theerawat Dobutr, Wirapong Kantamala, Suphaporn Phimwapi, Nisachon Jangpromma, Patcharaporn Tippayawat, Sophon Boonlue, Jureerut Daduang, Sompong Klaynongsruang, Saowanee Poopornchai, Sakda Daduang
Summary: This study investigated the immunomodulatory effect of edible bird's nest (EBN) in vitro and in vivo studies. The results showed that EBN specifically enhanced the expansion of CD3(+) T-cells and restored lymphocyte subpopulations under immunosuppressive drug influence. EBN treatments also increased the number of peripheral blood T-cells in rats and affected the numbers of lymphoid cells in specific areas. The elevation of serum interleukin-2 (IL-2) was correlated with T-cell proliferation. These findings are important for developing therapeutic strategies to improve immunity and T-cell homeostasis under immunosuppressive therapy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Man Yang, Yurou Che, Kezhen Li, Zengyi Fang, Simin Li, Mei Wang, Yiyao Zhang, Zhu Xu, Liping Luo, Chuan Wu, Xin Lai, Weidong Wang
Summary: Tumor-associated tertiary lymphoid structures (TLSs) are ectopic lymphoid formations within tumor tissue, which have a strong correlation with immunotherapy response and tumor prognosis. This study reviews the latest research progress on TLS detection and quantification, proposing new directions for assessment.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Immunology
Rafael S. Czepielewski, Emma C. Erlich, Emily J. Onufer, Shannon Young, Brian T. Saunders, Yong-Hyun Han, Mary Wohltmann, Peter L. Wang, Ki-Wook Kim, Shashi Kumar, Chyi-Song Hsieh, Joshua P. Scallan, Ying Yang, Bernd H. Zinselmeyer, Michael J. Davis, Gwendalyn J. Randolph
Summary: The formation of tertiary lymphoid organs (TLOs) in the mesentery is a feature of Crohn's disease, blocking cellular and molecular outflow from the gut and causing lymph leakage and backflow. TNF neutralization at early stages can restore lymph transport, but developed chronic TLOs resist regression and restoration of flow after TNF neutralization. TNF stimulation of lymphatic endothelial cells disrupts immune cell transport and valve-associated gene induction, contributing to Crohn's disease pathology.
Article
Medicine, General & Internal
Zu-feng Wang, Yi-chun Cheng, Yue-Qiang Li, Liu Liu, Shu-Wang Ge, Gang Xu
Summary: This study demonstrates the prevalence of TLOs in patients with MN and shows that patients with MN with TLOs have worse clinical manifestation and outcomes compared to patients without TLOs. Furthermore, the presence of TLOs is associated with specific clinical features and positive antibody status, highlighting their importance in MN.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Masayo Ukita, Junzo Hamanishi, Hiroyuki Yoshitomi, Koji Yamanoi, Shiro Takamatsu, Akihiko Ueda, Haruka Suzuki, Yuko Hosoe, Yoko Furutake, Mana Taki, Kaoru Abiko, Ken Yamaguchi, Hidekatsu Nakai, Tsukasa Baba, Noriomi Matsumura, Akihiko Yoshizawa, Hideki Ueno, Masaki Mandai
Summary: The formation of tertiary lymphoid structures (TLS) is associated with CXCL13-producing CD4+ T cells, and TLS facilitates the coordinated antitumor response of cellular and humoral immunity in ovarian cancer.
Article
Immunology
Yang Zhang, Yicong Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, Ran Tian, Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu, Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian, Shuyang Zhang
Summary: This study identified CCL17 chemokine as a contributor to age-related heart failure by regulating the plasticity and differentiation of T cells. The findings suggest CCL17 as a potential therapeutic target for age-related heart failure.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Motoki Nakamura, Tetsuya Magara, Shinji Kano, Akihiro Matsubara, Hiroshi Kato, Akimichi Morita
Summary: Tertiary lymphoid structures (TLSs) are potential prognostic markers in Merkel cell carcinoma (MCC), regardless of MCPyV status. CXCL13 and CCL5 expression levels may be useful prognostic markers and play a significant role in predicting prognosis in MCC patients.
FRONTIERS IN ONCOLOGY
(2022)