Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Tao Huang, Yang Gao, Yanwei Cao, Qinghai Wang, Zhen Dong
Summary: This study revealed the significant role of mmu_circ_0000943 in renal transplant by regulating miR-377-3p and Egr2, offering a novel insight into the treatment of AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Rajesh Kumar Goit, Andrew W. Taylor, Amy C. Y. Lo
Summary: Retinal ischemia/reperfusion (I/R) injury is a common cause of vision loss, particularly in diabetic retinopathy. Inflammation plays a major role in the pathogenesis of I/R injury. This study found that alpha-MSH, an anti-inflammatory peptide hormone, has protective effects against I/R-induced retinal damage in hyperglycemic conditions. Treatment with alpha-MSH improved retinal function, prevented histological alterations and retinal swelling, attenuated loss of retinal ganglion cells and oxidative stress, and increased the level of interleukin 10, which is linked to anti-inflammatory response. These findings suggest that alpha-MSH may have therapeutic potential for treating retinal I/R injury in diabetic patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Multidisciplinary
Banghua Zhang, Zhi-Yuan Chen, Zhengyu Jiang, Shiyu Huang, Xiu-Heng Liu, Lei Wang
Summary: Cardamonin (CAD) has been found to have antioxidant and anti-inflammatory properties, and can protect against kidney injury. In animal and cellular models, CAD was able to reduce kidney damage and improve renal function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Cell Biology
Yongmei Cao, Weifeng Huang, Fang Wu, Jiawei Shang, Feng Ping, Wei Wang, Yingchuan Li, Xuan Zhao, Xiaoping Zhang
Summary: ZFP36 plays a crucial role in lung injury induced by I/R, mediating inflammation-associated lung damage by interacting with the CREBBP/p53/p21/Bax pathway. The downregulation of ZFP36 increases the level of fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Kubra Koc, Fatime Geyikoglu, Ozge Cakmak, Aynur Koca, Zerrin Kutlu, Ferhunde Aysin, Asli Yilmaz, Hakan Askin
Summary: This study found that pretreatment with beta-sitosterol has a protective effect in renal ischemia/reperfusion injury, potentially mitigating inflammatory response and tissue damage by regulating oxidative stress.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Immunology
Ya-lin Zhu, Jie Huang, Xue-ying Chen, Jian Xie, Qing Yang, Jia-feng Wang, Xiao-ming Deng
Summary: SEI alleviates renal injury induced by ischemia reperfusion with anti-inflammatory, anti-endoplasmic reticulum stress, anti-oxidative, and anti-apoptotic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yun-Hai Luo, Zuo-Tian Huang, Ke-Zhen Zong, Zhen-Rui Cao, Da-Di Peng, Bao-Yong Zhou, Ai Shen, Ping Yan, Zhong-Jun Wu
Summary: The study identified miR-194- suppressed PHLDA1 as a critical intersection of dual inflammatory signals in hepatic IRI, showing that PHLDA1 upregulation could lead to liver pathological injury, apoptosis, and cytokine release. Overexpression of miR-194 decreased PHLDA1, alleviating the damage, and further enrichment of PHLDA1 reversed this effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yahong Fu, Junxian Gao, Yanqing Li, Xi Yang, Yun Zhang
Summary: This study demonstrates the significant role of tripartite motif-containing protein 21 (TRIM21) in cerebral ischemia/reperfusion injury. Inhibition of TRIM21 can alleviate the damage to neurons caused by oxygen-glucose deprivation/reoxygenation (OGD/R). This protective effect may be achieved by regulating the Keap1/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Zhi Zhao, Guoli Li, Yuxi Wang, Yinzheng Li, Huzi Xu, Wei Liu, Wenke Hao, Ying Yao, Rui Zeng
Summary: In this study, it was demonstrated that cytosolic HMGB1 induces ferroptosis by binding to ACSL4, exacerbating cellular injury in acute kidney injury (AKI). Inhibition of HMGB1 nucleocytoplasmic translocation and deletion of HMGB1 in tubular epithelial cells reduced AKI, tubular ferroptosis, and inflammation in mice. Co-immunoprecipitation and serial section staining confirmed the interaction between HMGB1 and ACSL4. These findings suggest that cytoplasmic HMGB1 is a regulator of ferroptosis and a promising therapeutic target for AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Bai, Xiong Wang, Cong Qin, Kang Yang, Zhiguo Duan, Zhixiu Cao, Jiaqian Liang, Lei Wang, Jingdong Yuan, Pengcheng Luo
Summary: This study found that Mindin plays a critical role in renal IR injury by regulating inflammatory responses and protecting the kidneys from damage caused by ischemia reperfusion. This protective effect may be mediated through the inhibition of TLR4/JNK/NF-κB signaling pathway activation.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Zhaohui Liu, Zhengping Wang, Guangwei Han, Lina Huang, Jihong Jiang, Shitong Li
JOURNAL OF SURGICAL RESEARCH
(2016)
Article
Nutrition & Dietetics
Yuanfeng Gong, Zhaohui Liu, Yadi Liao, Cong Mai, Tiejun Chen, Hui Tang, Yunqiang Tang
Article
Cell Biology
Zhaohui Liu, Junjie Zhang, Shitong Li, Jihong Jiang
Article
Cell Biology
Zhaohui Liu, Min Qu, Lili Yu, Panpan Song, Yulin Chang
Article
Surgery
Zhaohui Liu, Junjie Zhang, Xiaojing Huang, Lina Huang, Shitong Li, Zhengping Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Surgery
Zhaohui Liu, Yulin Chang, Junjie Zhang, Xiaojing Huang, Jihong Jiang, Shitong Li, Zhengping Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Surgery
Yulin Chang, Xiaojing Huang, Zhaohui Liu, Guangwei Han, Lina Huang, Yuan-Chang Xiong, Zhengping Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Genetics & Heredity
Qianjie Wei, Jinjuan Zhao, Xingguo Zhou, Lili Yu, Zhaohui Liu, Yulin Chang
Article
Engineering, Biomedical
Zhaohui Liu, Xiangge Liu, Qiang Yang, Lili Yu, Yulin Chang, Min Qu
ACTA BIOMATERIALIA
(2020)
Article
Biotechnology & Applied Microbiology
Peng Jiao, Weiming Li, Lin Shen, Yan Li, Lili Yu, Zhaohui Liu
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2020)
Article
Genetics & Heredity
Zhaohui Liu, Ji Zhang, Fang Zhang, Yulin Chang
Article
Cell Biology
Zhaohui Liu, Yan Li, Lili Yu, Yulin Chang, Jingui Yu
Article
Medicine, Research & Experimental
Qiang Yang, Zhaohui Liu, Yulin Chang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2016)