Patterns and Mechanisms of Diminishing Returns from Beneficial Mutations

Multi-environment fitness landscapes of a tRNA gene

(2018) Chuan Li et al.   Nature Ecology & Evolution

Genetic variation in adaptability and pleiotropy in budding yeast

(2017) Elizabeth R Jerison et al.   eLife

Diminishing-returns epistasis decreases adaptability along an evolutionary trajectory

(2017) Andrea Wünsche et al.   Nature Ecology & Evolution

The Genomic Architecture of Interactions Between Natural Genetic Polymorphisms and Environments in Yeast Growth

(2016) Xinzhu Wei et al.   GENETICS

Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatedness

(2016) Yinhua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminishing-returns epistasis among random beneficial mutations in a multicellular fungus

(2016) Sijmen Schoustra et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The fitness landscape of a tRNA gene

(2016) C. Li et al.   SCIENCE

The Genomic Architecture of Interactions Between Natural Genetic Polymorphisms and Environments in Yeast Growth

(2016) Xinzhu Wei et al.   GENETICS

Genomic investigations of evolutionary dynamics and epistasis in microbial evolution experiments

(2015) Elizabeth R Jerison et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds

(2015) M. Filteau et al.   Molecular Systems Biology

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

(2015) Joshua S. Bloom et al.   Nature Communications

The rule of declining adaptability in microbial evolution experiments

(2015) Alejandro Couce et al.   Frontiers in Genetics

Properties of selected mutations and genotypic landscapes under Fisher's geometric model

(2014) François Blanquart et al.   EVOLUTION

Biased Estimates of Diminishing-Returns Epistasis? Empirical Evidence Revisited

(2014) David Berger et al.   GENETICS

The Impact of Macroscopic Epistasis on Long-Term Evolutionary Dynamics

(2014) B. H. Good et al.   GENETICS

The predictability of molecular evolution during functional innovation

(2014) D. Blank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

The Changing Geometry of a Fitness Landscape Along an Adaptive Walk

(2014) Devin Greene et al.   PLoS Computational Biology

Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

(2014) Hsin-Hung Chou et al.   PLoS Genetics

SELECTION BIASES THE PREVALENCE AND TYPE OF EPISTASIS ALONG ADAPTIVE TRAJECTORIES

(2013) Jeremy A. Draghi et al.   EVOLUTION

RATES OF FITNESS DECLINE AND REBOUND SUGGEST PERVASIVE EPISTASIS

(2013) L. Perfeito et al.   EVOLUTION

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens

(2013) Omar Wagih et al.   NUCLEIC ACIDS RESEARCH

Long-Term Dynamics of Adaptation in Asexual Populations

(2013) M. J. Wiser et al.   SCIENCE

Epistasis from functional dependence of fitness on underlying traits

(2012) H.-C. Chiu et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Molecular Diversity of Adaptive Convergence

(2012) O. Tenaillon et al.   SCIENCE

The Genomic Landscape and Evolutionary Resolution of Antagonistic Pleiotropy in Yeast

(2012) Wenfeng Qian et al.   Cell Reports

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa

(2010) R. C. MacLean et al.   GENETICS

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks

(2010) Xionglei He et al.   NATURE GENETICS

Environmental duress and epistasis: how does stress affect the strength of selection on new mutations?

(2010) Aneil F. Agrawal et al.   TRENDS IN ECOLOGY & EVOLUTION

Abundant Indispensable Redundancies in Cellular Metabolic Networks

(2009) Zhi Wang et al.   Genome Biology and Evolution

The dynamics of adaptation on correlated fitness landscapes

(2009) S. Kryazhimskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast Growth Increases the Selective Advantage of a Mutation Arising Recurrently during Evolution under Metal Limitation

(2009) Hsin-Hung Chou et al.   PLoS Genetics