Article
Pharmacology & Pharmacy
Silvia Voci, Agnese Gagliardi, Nicola Ambrosio, Maria Cristina Salvatici, Massimo Fresta, Donato Cosco
Summary: Doxorubicin hydrochloride (DOX) is a widely used antitumor drug, but its off-target toxicity limits its administration. Nanoparticles made of wheat gliadin and polyoxyethylene (2) oleyl ether were investigated as carriers for DOX. These nanoparticles showed great stability, retained high amounts of drug, and exhibited prolonged and sustained release. The encapsulation of DOX modulated its cytotoxicity against breast cancer cells compared to the free form of the drug, demonstrating the potential use of these nanoparticles as carriers for hydrophilic antitumor compounds.
Article
Multidisciplinary Sciences
Shu-Hui Wu, Chia-Chu Hsieh, Szu-Chun Hsu, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Chih-Peng Lin, Dong-Ming Huang
Summary: The study demonstrates that Dox-gluRDVs exhibit superior anticancer activity compared to free Dox by efficiently delivering the majority of their conjugated Dox into lysosomes, resulting in mitochondrial ROS overproduction and activation of apoptotic signaling for enhanced anticancer activity.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Yannick Audet-Delage, Catherine St-Louis, Lucia Minarrieta, Shawn Mcguirk, Irwin Kurreal, Matthew G. Annis, Arvind Singh Mer, Peter M. Siegel, Julie St-Pierre
Summary: This study reveals an important priming phase that renders cancer cells resistant to escalating drug concentrations, and identifies specific solute carriers and associated metabolites involved in chemotherapy resistance. In breast tumors from patients, high expression of these solute carriers is associated with reduced survival.
Review
Chemistry, Applied
Jaya R. Lakkakula, Pratik Gujarathi, Prachi Pansare, Swastika Tripathi
Summary: Combining alginate with other materials as a drug delivery system can effectively enhance the targeted therapeutic effects of doxorubicin on cancer, showing great potential for widespread applications.
CARBOHYDRATE POLYMERS
(2021)
Review
Medicine, Research & Experimental
Mahshid Deldar Abad Paskeh, Hamidreza Saebfar, Mahmood Khaksary Mahabady, Sima Orouei, Kiavash Hushmandi, Maliheh Entezari, Mehrdad Hashemi, Amir Reza Aref, Michael R. Hamblin, Hui Li Ang, Alan Prem Kumar, Ali Zarrabi, Saeed Samarghandian
Summary: Gene therapy can be used as a cancer therapy by affecting signaling networks participating in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool employed to increase drug sensitivity and reduce drug resistance. By targeting oncogenic pathways and regulating drug transporter activity, siRNA can increase drug accumulation and enhance cytotoxicity. The use of nanoparticles as carriers and smart nanostructures with pH, redox, and light responsiveness can optimize siRNA and drug delivery for tumor treatment.
Article
Pharmacology & Pharmacy
Chih-Peng Lin, Shu-Hui Wu, Tzu-Yin Lin, Chia-Hui Chu, Leu-Wei Lo, Ching-Chuan Kuo, Jang-Yang Chang, Szu-Chun Hsu, Bor-Sheng Ko, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Dong-Ming Huang
Summary: This study develops a simple and versatile biological drug delivery system (bDDS) based on human red blood cell-derived vesicles (RDVs), which shows excellent biocompatibility for cancer chemotherapy. The bDDS, named Dox-gluRDVs, effectively suppress multidrug resistance in uterine sarcoma by inducing cell death through a lysosomal-mitochondrial axis-dependent mechanism.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ghazaleh Khalili-Tanha, Meysam Moghbeli
Summary: Resistance to conventional chemotherapeutic agents like DOX is a major challenge in cancer therapy, necessitating the exploration of new treatment modalities. Long non-coding RNAs play critical roles in drug resistance in tumors, with many associated with DOX resistance. This review lays the groundwork for introducing an lncRNA panel marker to predict DOX response and clinical outcomes in cancer patients.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Oncology
Isabella Giacomini, Margherita Cortini, Mattia Tinazzi, Nicola Baldini, Veronica Cocetta, Eugenio Ragazzi, Sofia Avnet, Monica Montopoli
Summary: Osteosarcoma, the most common bone tumor in children and young adults, is also the second most fatal cancer. Despite the clinical benefit of chemotherapy, patients with osteosarcoma still face a poor prognosis due to drug resistance and frequent growth and metastasis of the disease. This study reveals a different mitochondrial phenotype in doxorubicin-resistant cancer cells and suggests targeting the altered pathway to reverse drug resistance. These findings contribute to understanding mitochondrial metabolism changes and developing strategies to overcome doxorubicin resistance in osteosarcoma.
Article
Chemistry, Physical
Laxmikanta Khamari, Srikrishna Pramanik, Shashi Shekhar, Paritosh Mahato, Saptarshi Mukherjee
Summary: The study elucidated the binding mechanism of the anticancer drug EPR with DNA mismatched base pairs, demonstrating its stronger affinity towards thermodynamically unstable DNA and its potential use in drug sequestration through a mixed micellar system.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Shiori Nishiuchi, Kenta Yagi, Hiroumi Saito, Yoshito Zamami, Takahiro Niimura, Koji Miyata, Yoshika Sakamoto, Kimiko Fukunaga, Shunsuke Ishida, Hirofumi Hamano, Fuka Aizawa, Mitsuhiro Goda, Masayuki Chuma, Yuki Izawa-Ishizawa, Hideki Nawa, Hiroaki Yanagawa, Yasunari Kanda, Keisuke Ishizawa
Summary: In this study, databases were used to explore approved drugs with potential preventative effects against doxorubicin-induced cardiac events. Mosapride and sirolimus were identified as drugs that can suppress doxorubicin-induced cardiotoxicity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nuzhat Bano, Mohammad Imran Ansari, K. M. Kainat, Vipendra Kumar Singh, Pradeep Kumar Sharma
Summary: Chloroquine has been shown to enhance the anticancer efficacy of doxorubicin in cervical cancer cells. The combination of doxorubicin and chloroquine resulted in synergistic cytotoxicity by impairing autophagic flux and enhancing apoptosis. These findings suggest that chloroquine, as a repurposed drug, has the potential to synergize with doxorubicin in treating cervical cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Zi'an Wang, Yueqin Wang, Zeyun Li, Wenhua Xue, Shousen Hu, Xiangzhen Kong
Summary: Cancer is the leading cause of human death today and its treatment process is complex. Drug resistance is a significant issue in cancer treatment, and lipid metabolism has been found to be closely related to drug resistance. Combination therapy may reverse the development of drug resistance and enhance sensitivity to therapeutic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Blake R. Rushing, Sabrina Molina, Susan Sumner
Summary: This study investigated metabolic changes in doxorubicin-resistant triple-negative breast cancer cells. Two drug-resistant cell lines, DOX-RES-50 and DOX-RES-100, were generated through doxorubicin treatment. Metabolomics analysis revealed significant perturbations in several metabolic pathways in the drug-resistant cell lines. The study's findings provide insight into how metabolism is altered during the acquisition of resistance in TNBC cells and how the metabolic response to doxorubicin changes upon repeated treatment, which can potentially identify novel targets to prevent or reverse multi-drug resistance in TNBC.
Article
Chemistry, Multidisciplinary
Fatemeh Yaghoubi, Seyed Morteza Naghib, Najmeh Sadat Hosseini Motlagh, Fateme Haghiralsadat, Hossein Zarei Jaliani, Davood Tofighi, Ali Moradi
Summary: Graphene oxide has attracted attention as a novel drug delivery system, with a biocompatible APT-GO-COOH synthesized for the co-delivery of chemotherapeutics and herbal drugs. The co-delivery system showed a thermo- and pH-sensitive drug release behavior, reducing the expression of certain genes and proteins while enhancing others, and effectively targeting gastric cancer cells.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Kambiz Ghaseminasab, Nastaran Aletaha, Mohammad Hasanzadeh
Summary: This study aims to develop a portable tool for the colorimetric and spectrophotometric detection of Hyd using silver nanoparticles. The method shows both qualitative and quantitative measurement of Hyd with high sensitivity, low cost, and fast analysis time, and can potentially be industrialized for quick detection of Hyd in aquatic real samples.
Article
Multidisciplinary Sciences
Yalda Zare, Maral Maghsoudi-Salek, Zahra Golsanamlu, Abolghasem Jouyban, Jafar Soleymani, Hassan Bagherpour-Shamloo
Summary: Early-stage detection plays a crucial role in cancer treatment and prognosis. A newly developed folic acid-functionalized silica quantum dots (SiQDs)/KCC-NH2@SiO2 nanomaterials showed specificity towards MCF 7 cancer cells overexpressing folate receptor (FR). These nanoparticles exhibited biocompatibility and stability, making them promising for in vivo bio-imaging of FR-overexpressed circulating tumoral cancer cells (CTCs).
Article
Chemistry, Analytical
Milad Moradi, Abolghasem Jouyban, Afshin Gharakhani, Hamid Noshad, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Elaheh Rahimpour
Summary: A simple and sensitive Rayleigh light scattering method was developed for the quantification of p-cresol in exhaled breath condensate. The method is based on an aggregation of anthracene nanoparticles in acidic media after adding p-cresol, resulting in a marked enhancement in RLS intensity at 410 nm. The validated method was applied for the analysis of p-cresol in EBC samples taken from patients suffering chronic kidney disease.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Zahra Golsanamlu, Jafar Soleymani, Afshin Gharekhani, Abolghasem Jouyban
Summary: A novel ratiometric fluorescent sensor based on ZIF-8-AgNPs@NE was developed for the quantification of CsA in human plasma samples. It showed a quenching effect on the fluorescent emission intensity in the presence of CsA. The probe demonstrated a facile and fast platform with a low limit of detection for CsA.
Article
Chemistry, Analytical
Zahra Karimzadeh, Afshin Gharekhani, Elaheh Rahimpour, Abolghasem Jouyban
Summary: A synchronous fluorescence spectroscopy (SFS) sensor for pethidine detection was developed using UiO-66 metal-organic frameworks (MOFs) modified with N-doped carbon quantum dots (N-CQDs) embedded in hydrogel nanocomposites. N-CQDs were successfully deposited in the pores of the UiO-66 network and used as a sensitive segment. UiO-66 was employed for sensing the bonding interactions between N-CQDs and pethidine, resulting in quenching the SFS intensity of UiO-66. The nanocomposite hydrogel showed two well-resolved emission peaks corresponding to N-CQDs and UiO-66 and was used for ratiometric detection of pethidine with a low limit of detection.
Article
Chemistry, Multidisciplinary
Samira Radmand, Homa Rezaei, Hongkun Zhao, Elaheh Rahimpour, Abolghasem Jouyban
Summary: This study aims to determine the solubility, density, and thermodynamic parameters of deferiprone in propylene glycol and ethanol. The shake-flask technique and spectrophotometry method were used for solid-liquid equilibration and solubility measurement, respectively. The solubility and density of deferiprone in propylene glycol and ethanol mixtures were measured at temperatures ranging from 293.2 to 313.2 K. Various mathematical equations were employed for data modeling, and the apparent thermodynamic parameters of the deferiprone dissolution process were calculated and reported.
Article
Multidisciplinary Sciences
Homa Rezaei, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban
Summary: This investigation studied the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol. The solubility of deferiprone showed a positive correlation with temperature and propylene glycol mass fraction. Mathematical models were used to correlate the solid-liquid equilibrium data, and the computed data showed good agreement with the experimental data with low mean relative deviation values. The thermodynamic behavior of deferiprone dissolution was also investigated using van't Hoff and Gibbs equation.
Article
Thermodynamics
Cunliang Zhang, Yanmei Liu, Haotian Guo, Abolghasem Jouyban, Hongkun Zhao
Summary: This study investigated the solubility, solvation behavior, dissolution thermodynamics, and intermolecular interactions of 18 beta-glycyrrhetinic acid (GA) in different aqueous blends. The solubility of GA was found to be the lowest in water and highest in pure organic solvents. The solubility was influenced by the dipolarity-polarizability and solubility parameter of the solutions. The preferential solvation of GA by organic solvents was quantitatively examined, and it was found that GA acts as a Lewis acid with respect to the cosolvent molecules. Thermodynamic investigation revealed that the dissolution of GA is an endothermic process driven by enthalpy. The electrostatic properties of acidity/basicity of GA and the weak interactions between GA and solvent were also examined.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2023)
Article
Thermodynamics
Chaobin Ren, Abolghasem Jouyban, Hongkun Zhao
Summary: Quantitative analysis of molecular surface was used to highlight the electrostatic properties of bisacodyl, with the lowest global electrostatic potentials observed on the -C = O and -N = groups. The weak interactions between bisacodyl and solvents were examined using the Hirshfeld partition analysis-based independent gradient model. Solubility of bisacodyl in different solvent blends was evaluated using the isothermal shake-flask method, and the solubility variation was mainly attributed to solvent-solvent and solute-solvent interactions. Different models were used to analyze the connection between solubility and temperature, producing a largest relative average deviation of 9.41%. The preferred solvation of bisacodyl was observed in medium and rich concentrations of isopropanol, methanol, and ethanol. The dissolution of bisacodyl was found to be entropy-driven in all solvent mixtures.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2023)
Article
Chemistry, Physical
Abolghasem Jouyban, William E. Acree Jr
Summary: The experimental solubility data of glimepiride in different solvents and solvent mixtures were re-evaluated to meet the practical needs of the pharmaceutical industry. Trained models were used to predict the solubility data based on a minimum number of known data points. The accuracy of the prediction tools was satisfactory.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Parisa Jafari, Mohammad Barzegar-Jalali, Salar Hemmati, Abolghasem Jouyban
Summary: The equilibrium solubility of isophthalic acid (IPA) in various betaine-based deep eutectic solvents (DESs) was determined experimentally, and it was found that decreasing water content increased the solubility. The solubility was highest in the betaine/propylene glycol (PG) mixture, possibly due to the lower dipole moment and dielectric constant of PG compared to the other solvents. The H-bonding interactions between the components of the DESs disappeared when the water content exceeded 60%.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Multidisciplinary Sciences
Zahra Golsanamlu, Jafar Soleymani, Afshin Gharekhani, Abolghasem Jouyban
Summary: A colorimetric platform using silver nanoparticles has been developed for the determination of Tacrolimus concentration. The method is sensitive and selective, with a low limit of detection. It has been successfully applied for therapeutic drug monitoring of Tacrolimus in patient's plasma samples.
Review
Chemistry, Multidisciplinary
Raha Kaviani, Abolghasem Jouyban, Ali Shayanfar
Summary: This review outlines the crucial importance of pharmaceutical cocrystals in chiral resolution techniques of racemic compounds, discussing different cocrystallization methods.
Article
Chemistry, Multidisciplinary
Bita Azad, Zahra Karimzadeh, Amirreza Jabbaripour, Vahid Jouyban-Gharamaleki, Maryam Khoubnasabjafari, Abolghasem Jouyban, Elaheh Rahimpour
Summary: This article presents a method combining solid-phase extraction with spectrofluorometric analysis for the extraction and determination of metoprolol in exhaled breath condensate. The method is sensitive and has a wide linear range, and has been successfully applied to clinical sample testing.
Article
Chemistry, Multidisciplinary
Nafiseh Gholizadeh, Jalal Hanaee, Elaheh Rahimpour, Abolghasem Jouyban
Summary: This study determined the solubility of acetaminophen in a mixture of glycerol and ethanol using a shake-flask technique at different temperatures. Mathematical models were fitted to the data, and their accuracy was evaluated. The density of saturated mixtures and the thermodynamic parameters of acetaminophen dissolving were also investigated.
OVIDIUS UNIVERSITY ANNALS OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)
