Enzyme-based logic gates and circuits—analytical applications and interfacing with electronics

Multi-input and -output logic circuits based on bioelectrocatalysis with horseradish peroxidase and glucose oxidase immobilized in multi-responsive copolymer films on electrodes

(2016) Xue Yu et al.   BIOSENSORS & BIOELECTRONICS

An Enzyme-Based Half-Adder and Half-Subtractor with a Modular Design

(2016) Brian E. Fratto et al.   CHEMPHYSCHEM

Bioelectronic Interface Connecting Reversible Logic Gates Based on Enzyme and DNA Reactions

(2016) Nataliia Guz et al.   CHEMPHYSCHEM

Controlled Logic Gates-Switch Gate and Fredkin Gate Based on Enzyme-Biocatalyzed Reactions Realized in Flow Cells

(2016) Brian E. Fratto et al.   CHEMPHYSCHEM

Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate

(2016) Denise Molinnus et al.   SENSORS AND ACTUATORS B-CHEMICAL

Multienzyme Inkjet Printed 2D Arrays

(2015) Efrat Gdor et al.   ACS Applied Materials & Interfaces

Multiple-Stimuli Responsive Bioelectrocatalysis Based on Reduced Graphene Oxide/Poly(N-isopropylacrylamide) Composite Films and Its Application in the Fabrication of Logic Gates

(2015) Lei Wang et al.   ACS Applied Materials & Interfaces

Enzyme Induced Stiffening of Nanoparticle–Hydrogel Composites with Structural Color

(2015) Omar B. Ayyub et al.   ACS Nano

Enzyme-regulated the changes of pH values for assembling a colorimetric and multistage interconnection logic network with multiple readouts

(2015) Yanyan Huang et al.   ANALYTICA CHIMICA ACTA

Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems

(2015) Shay Mailloux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane

(2015) A. Poghossian et al.   CHEMICAL COMMUNICATIONS

Design of enzyme-interfaced DNA logic operations (AND, OR and INHIBIT) with an assaying application for single-base mismatch

(2015) Long Ma et al.   CHEMICAL COMMUNICATIONS

Reversible Logic Gates Based on Enzyme-Biocatalyzed Reactions and Realized in Flow Cells: A Modular Approach

(2015) Brian E. Fratto et al.   CHEMPHYSCHEM

Biocomputing — tools, aims, perspectives

(2015) Evgeny Katz   CURRENT OPINION IN BIOTECHNOLOGY

Substance Release Triggered by Biomolecular Signals in Bioelectronic Systems

(2015) Evgeny Katz et al.   Journal of Physical Chemistry Letters

Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids

(2015) Arshak Poghossian et al.   Nanoscale

Concept for a biomolecular logic chip with an integrated sensor and actuator function

(2015) Denise Molinnus et al.   PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE

Notes on stochastic (bio)-logic gates: computing with allosteric cooperativity

(2015) Elena Agliari et al.   Scientific Reports

An enzyme logic bioprotonic transducer

(2015) Takeo Miyake et al.   APL Materials

Exercises in Molecular Computing

(2014) Milan N. Stojanovic et al.   ACCOUNTS OF CHEMICAL RESEARCH

An enzyme-based reversible CNOT logic gate realized in a flow system

(2014) Fiona Moseley et al.   ANALYST

A biocatalytic cascade with several output signals—towards biosensors with different levels of confidence

(2014) Nataliia Guz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Logic Gate System with Three Outputs and Three Inputs Based on Switchable Electrocatalysis of Glucose by Glucose Oxidase Entrapped in Chitosan Films

(2014) Shuang Liu et al.   Chemistry-An Asian Journal

Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications

(2014) Vladimir Privman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Majority and Minority Gates Realized in Enzyme-Biocatalyzed Systems Integrated with Logic Networks and Interfaced with Bioelectronic Systems

(2014) Shay Mailloux et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein AND Enzyme Gated Supramolecular Disassembly

(2014) Jing Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel–enzyme hybrids

(2014) Masato Ikeda et al.   Nature Chemistry

Role of biomolecular logic systems in biosensors and bioactuators

(2014) Shay Mailloux et al.   OPTICAL ENGINEERING

Can bio-inspired information processing steps be realized as synthetic biochemical processes?

(2014) Vladimir Privman et al.   PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE

Biocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American groups

(2013) Friederike Kramer et al.   ANALYST

Biocatalytic analysis of biomarkers for forensic identification of gender

(2013) Saira Bakshi et al.   ANALYST

Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices

(2013) A. Poghossian et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Graphene oxide-based fluorescent detection of DNA and enzymes using Hoechst 33258 and its use for dual-output fluorescent logic gates

(2013) Wenting Liu et al.   Analytical Methods

Dual enzyme responsive microcapsules simulating an “OR” logic gate for biologically triggered drug delivery applications

(2013) Krishna Radhakrishnan et al.   CHEMICAL COMMUNICATIONS

Modularity of Biochemical Filtering for Inducing Sigmoid Response in Both Inputs in an Enzymatic AND Gate

(2013) Saira Bakshi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output

(2013) Vladimir Privman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Electrochemical biocomputing: a new class of molecular-electronic logic devices

(2013) Yongmei Jia et al.   Soft Matter

Enzymatic filter for improved separation of output signals in enzyme logic systems towards ‘sense and treat’ medicine

(2013) Shay Mailloux et al.   Biomaterials Science

Redox Capacitor to Establish Bio-Device Redox-Connectivity

(2012) Eunkyoung Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Analysis of biomarkers characteristic of porcine liver injury—from biomolecular logic gates to an animal model

(2012) Lenka Halámková et al.   ANALYST

Multianalyte Digital Enzyme Biosensors with Built-in Boolean Logic

(2012) Evgeny Katz et al.   ANALYTICAL CHEMISTRY

A Self-Powered “Sense-Act-Treat” System that is Based on a Biofuel Cell and Controlled by Boolean Logic

(2012) Ming Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-amplified electronic logic gates based on split/intactaptamers

(2012) Junhua Chen et al.   BIOSENSORS & BIOELECTRONICS

Molecular AND logic gate based on bacterial anaerobic respiration

(2012) Mary Anitha Arugula et al.   CHEMICAL COMMUNICATIONS

Information Processing with Molecules-Quo Vadis?

(2012) Uwe Pischel et al.   CHEMPHYSCHEM

Biomolecular Computers

(2012) Inaki Sainz de Murieta et al.   Current Bioinformatics

Biofuel Cells for Self-Powered Electrochemical Biosensing and Logic Biosensing: A Review

(2012) Ming Zhou et al.   ELECTROANALYSIS

Electronic interfaces switchable by logically processed multiple biochemical and physiological signals

(2012) Evgeny Katz et al.   JOURNAL OF MATERIALS CHEMISTRY

Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid “Filter” Response

(2012) Jan Halámek et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response

(2012) Oleksandr Zavalov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications

(2012) Sergii Domanskyi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biomolecular computing systems: principles, progress and potential

(2012) Yaakov Benenson   NATURE REVIEWS GENETICS

Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling

(2012) Maryam H. Abouzar et al.   PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE

A mechanical Turing machine: blueprint for a biomolecular computer

(2012) E. Shapiro   Interface Focus

Electrochemically Controlled Drug-Mimicking Protein Release from Iron-Alginate Thin-Films Associated with an Electrode

(2011) Zhiyuan Jin et al.   ACS Applied Materials & Interfaces

Biomolecular Filters for Improved Separation of Output Signals in Enzyme Logic Systems Applied to Biomedical Analysis

(2011) Jan Halámek et al.   ANALYTICAL CHEMISTRY

Employing the Metabolic “Branch Point Effect” to Generate an All-or-None, Digital-like Response in Enzymatic Outputs and Enzyme-Based Sensors

(2011) Sandra Perez Rafael et al.   ANALYTICAL CHEMISTRY

Switchable electrode interfaces controlled by physical, chemical and biological signals

(2011) Vera Bocharova et al.   CHEMICAL RECORD

Enzyme Logic Gates Based on Enzyme-Coated Carbon Nanotubes

(2011) Kyung-Woo Kim et al.   ELECTROANALYSIS

Integration of biomolecular logic gates with field-effect transducers

(2011) A. Poghossian et al.   ELECTROCHIMICA ACTA

Boolean logic gates based on oxygen-controlled biofuel cell in “one pot”

(2011) Ming Zhou et al.   ELECTROCHIMICA ACTA

Building Logic into Peptide Networks: Bottom-Up and Top-Down

(2011) Gonen Ashkenasy et al.   ISRAEL JOURNAL OF CHEMISTRY

Digital Biosensors with Built-in Logic for Biomedical Applications

(2011) Joseph Wang et al.   ISRAEL JOURNAL OF CHEMISTRY

Chemistry at a Higher Level of Abstraction

(2011) Milan N. Stojanovic et al.   Journal of Computational and Theoretical Nanoscience

Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Enzyme Inhibition by a Substrate

(2011) Jan Halámek et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Towards biochemical filters with a sigmoidal response to pH changes: buffered biocatalytic signal transduction

(2011) Marcos Pita et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Alert-type biological dosimeter based on enzyme logic system

(2011) Vera Bocharova et al.   TALANTA

Multiplexing of injury codes for the parallel operation of enzyme logic gates

(2010) Jan Halámek et al.   ANALYST

Digital biosensors with built-in logic for biomedical applications—biosensors based on a biocomputing concept

(2010) Joseph Wang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Advanced Molecular Logic with Memory Function

(2010) Uwe Pischel   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-based logic systems for information processing

(2010) Evgeny Katz et al.   CHEMICAL SOCIETY REVIEWS

A Self-Powered and Reusable Biocomputing Security Keypad Lock System Based on Biofuel Cells

(2010) Ming Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic

(2010) Vladimir Privman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Signal Change

(2010) Vladimir Privman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biomoleküle ankoppeln

(2010) Lars A. Haller et al.   NACHRICHTEN AUS DER CHEMIE

Bio-logic analysis of injury biomarker patterns in human serum samples

(2010) Jian Zhou et al.   TALANTA

Stimuli-Responsive Hydrogel Membranes Coupled with Biocatalytic Processes

(2009) Ihor Tokarev et al.   ACS Applied Materials & Interfaces

Enzyme logic gates for the digital analysis of physiological level upon injury

(2009) Kalayil Manian Manesh et al.   BIOSENSORS & BIOELECTRONICS

Biofuel Cells Controlled by Logically Processed Biochemical Signals: Towards Physiologically Regulated Bioelectronic Devices

(2009) Evgeny Katz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Switchable Electrodes: How Can the System Complexity be Scaled up?

(2009) Marcos Pita et al.   ELECTROANALYSIS

Analog Noise Reduction in Enzymatic Logic Gates

(2009) Dmitriy Melnikov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzyme-BasedNANDandNORLogic Gates with Modular Design

(2009) Jian Zhou et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information

(2009) Melina Krämer et al.   Journal of Physical Chemistry C

Reversible “Closing” of an Electrode Interface Functionalized with a Polymer Brush by an Electrochemical Signal

(2009) Tsz Kin Tam et al.   LANGMUIR

Biocomputers: from test tubes to live cells

(2009) Yaakov Benenson   Molecular BioSystems

Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors

(2009) José R. Siqueira et al.   PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE

Boolean Logic Gates that Use Enzymes as Input Signals

(2008) Guinevere Strack et al.   CHEMBIOCHEM

Digital Information Processing in Molecular Systems

(2008) Konrad Szaciłowski   CHEMICAL REVIEWS

Optimization of Enzymatic Biochemical Logic for Noise Reduction and Scalability: How Many Biocomputing Gates Can Be Interconnected in a Circuit?

(2008) Vladimir Privman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Polymer Brush-Modified Electrode with Switchable and Tunable Redox Activity for Bioelectronic Applications

(2008) Tsz Kin Tam et al.   Journal of Physical Chemistry C

Biocomputing Security System:  Concatenated Enzyme-Based Logic Gates Operating as a Biomolecular Keypad Lock

(2008) Guinevere Strack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Switchable Electrode Controlled by Enzyme Logic Network System: Approaching Physiologically Regulated Bioelectronics

(2008) Marina Privman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards molecular computers that operate in a biological environment

(2008) Maya Kahan et al.   PHYSICA D-NONLINEAR PHENOMENA