Article
Endocrinology & Metabolism
Jay Kumar, Ghulam Mohammad, Kumari Alka, Renu A. Kowluru
Summary: Mitochondrial dysfunction plays a critical role in the development of diabetic retinopathy. Hyperglycemia downregulates the mtDNA-encoded LncRNA cytochrome B (LncCytB) in retinal endothelial cells, leading to impaired mtDNA packaging and increased vulnerability to damage.
Article
Environmental Sciences
Songhee Lee, Sungjong Lee, Eun Hea Jho, Sooim Shin, Chang Min Park
Summary: This study reveals that FeAB may induce oxidative stress in Daphnia, inhibiting their antioxidant system. Exposure to low concentrations of FeAB results in higher ROS/RNS levels, indicating antioxidant mechanism failure, while exposure to relatively high concentrations leads to reduced ROS/RNS levels possibly due to decreased production from cell damage.
Article
Multidisciplinary Sciences
Rafiq Ahmed Bhat, Syed Maqbool, Syed Manzoor Ali, Akanksha Rathi, Wentao Xiao, You Zhang, Haixia Fu, Chuanyu Gao
Summary: The study compared the in vitro toxicity of cadmium on erythrocytes of camels and cows, finding that cadmium exposure led to greater impacts on bovine erythrocytes compared to camel erythrocytes. Cadmium exposure impaired the antioxidant system of bovine erythrocytes, increasing their susceptibility to hemolysis, while camel erythrocytes exhibited increased resistance to oxidative stress from cadmium exposure.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Muthuswamy Sathyabhama, Loganathan Chandramani Priya Dharshini, Adhimoolam Karthikeyan, Senthil Kalaiselvi, Taesun Min
Summary: Oxidative stress and mitochondrial dysfunction are closely linked to the development of various human diseases. Curcumin, a bioactive compound found in turmeric, has been shown to reduce oxidative stress and mitochondrial dysfunction, leading to potential therapeutic effects in these diseases.
Article
Plant Sciences
M. Nalina, S. Saroja, M. Chakravarthi, R. Rajkumar, B. Radhakrishnan, K. N. Chandrashekara
Summary: The study found that tolerant genotypes of tea plants maintained better water relations, higher photosynthetic pigments, and reduced membrane injury compared to susceptible cultivars under water deficit conditions. Additionally, the lower efficiency of antioxidative enzymes in susceptible cultivars made them more prone to oxidative damage, while the accumulation of osmolytes played a significant role in drought tolerance.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Pharmacology & Pharmacy
Ahmad Salimi, Zhaleh Jamali, Mohammad Shabani
Summary: Oxidative stress and mitochondrial dysfunction play crucial roles in the cardiac toxicity induced by aluminum phosphide. Myricetin, a flavonoid, shows potential in protecting cardiomyocytes and mitochondria from AlP-induced toxicity by reducing oxidative stress and cellular damage, suggesting its therapeutic potential in alleviating the adverse effects of AlP on the heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sylvia Maina, Da Hye Ryu, Jwa Yeong Cho, Da Seul Jung, Jai-Eok Park, Chu Won Nho, Gaymary Bakari, Gerald Misinzo, Je Hyeong Jung, Seung-Hoon Yang, Ho-Youn Kim
Summary: The study evaluated the effects of salt treatment and different light wavelengths on glucosinolates and phenolic compounds in Brassica carinata microgreens. The results showed that salt treatment and specific light conditions can enhance antioxidant activities, promote the accumulation of glucosinolates, and potentially treat and prevent oxidative stress and inflammatory disorders.
Article
Biochemistry & Molecular Biology
Maria Lopez-Pedrouso, Jose M. Lorenzo, Zulema Varela, J. Angel Fernandez, Daniel Franco
Summary: Aquaculture production is an important source of protein in our diet, but marine pollution poses serious challenges to the food safety of molluscs. The discovery of protein biomarkers through proteomic technologies can help monitor pollutants and improve protocols for seafood safety in the face of growing marine pollution.
Article
Biochemistry & Molecular Biology
Marta Budkowska, Elzbieta Cecerska-Heryc, Zuzanna Marcinowska, Aldona Siennicka, Barbara Dolegowska
Summary: This study aimed to investigate the activity of several enzymes related to oxidative stress and the concentration of glutathione in the circadian rhythm. The results showed that the activity of these enzymes and the concentration of glutathione peaked at 2 a.m. during sleep. This suggests that the processes maintaining the redox balance are intensified during sleep, thus reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Monica Garcia Silva, Paulo Nunes, Paula Oliveira, Rita Ferreira, Margarida Fardilha, Daniel Moreira-Goncalves, Jose Alberto Duarte, Maria Manuel Oliveira, Francisco Peixoto
Summary: This study demonstrates the lifelong benefits of aerobic exercise in preventing age-related consequences on liver function and antioxidant activity. The duration of the training protocol might be more critical for the adaptive response than exercise intensity. Regular aerobic exercise can prevent mitochondrial dysfunction and loss of antioxidant system efficacy in the liver associated with aging.
Article
Plant Sciences
Asad Rehman, Jinyang Weng, Pengli Li, Jing Yu, Saeed Ur Rahman, Muhammad Khalid, Iftikhar Hussain Shah, Shazma Gulzar, Liying Chang, Qingliang Niu
Summary: The aim of this study was to investigate the response mechanisms of drought stress tolerance in two melon genotypes. Drought stress led to significant effects on the drought-sensitive genotype, while the drought-resistant genotype exhibited a robust response. Antioxidant enzyme genes and activities were upregulated in the drought-resistant genotype, resulting in decreased oxidative damage and improved growth and photosynthetic functions. The findings provide insights into coping strategies for drought stress tolerance and have implications for melon breeding and molecular studies.
JOURNAL OF PLANT BIOLOGY
(2023)
Article
Microbiology
Huirong Zhang, Jason P. Wong, Guoxin Ni, Patricio Cano, Dirk P. Dittmer, Blossom Damania
Summary: The study identified a cellular factor called TBRG4 that regulates the lytic reactivation of KSHV and EBV by controlling the production of reactive oxygen species (ROS). Knockdown of TBRG4 induced viral lytic gene transcription and replication in cells latently infected with KSHV or EBV. This research provides insights into the molecular mechanism of gammaherpesvirus reactivation and suggests TBRG4 as a potential therapeutic target for virus-associated malignancies.
Review
Pharmacology & Pharmacy
Chennan Wu, Zhen Zhang, Weidong Zhang, Xia Liu
Summary: Cardiovascular diseases, including heart failure, are leading causes of death globally. Despite advancements in therapies, life expectancy for heart failure remains poor. Targeting mitochondrial dysfunction, which is closely related to heart failure, may be an effective approach for treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jakub Rok, Zuzanna Rzepka, Mateusz Maszczyk, Artur Beberok, Dorota Wrzesniok
Summary: Minocycline, a semisynthetic tetracycline antibiotic, not only exhibits antibacterial activity but also shows antioxidative effects. Long-term use of minocycline may cause skin hyperpigmentation. Research indicates that minocycline induces oxidative stress in human melanocytes but can also increase cell viability and mitigate oxidative stress when exposed to hydrogen peroxide and UVA radiation. Additionally, the different impact of minocycline on CAT activity compared to other tetracyclines may be attributed to the binding site location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Shiva Ganjali, Reihaneh Keshavarz, Susan Hosseini, Atena Mansouri, Massimo R. Mannarino, Matteo Pirro, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study revealed significant differences in oxidant/antioxidant markers between FH patients and healthy individuals, as well as between HoFH and HeFH patients. These differences may be strongly associated with plasma LDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Liqian Zhu, Clinton Jones, Gaiping Zhang
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Virology
Liqian Zhu, Xinyi Jiang, Xiaotian Fu, Yanhua Qi, Guoqiang Zhu
Article
Cell Biology
Xiaotian Fu, Dongmei Chen, Yan Ma, Weifeng Yuan, Liqian Zhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Virology
Wencai Qiu, Long Chang, Yongming He, Liqian Zhu
Review
Biochemistry & Molecular Biology
Xiuyan Ding, Shitao Li, Liqian Zhu
Summary: Inflammatory responses play a crucial role in protecting the host against invading pathogens, but excessive production of proinflammatory cytokines can lead to severe tissue damage. HMGB1, as a potential host factor, is manipulated by distinct viruses through various mechanisms to regulate viral diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Wencai Qiu, Xiuyan Ding, Shitao Li, Yongming He, Liqian Zhu
Summary: The study demonstrates that BoHV-1 has oncolytic effects against human lung adenocarcinoma in vivo. BoHV-1 infection reduced HDAC protein levels in A549 cells and showed synergy with the HDAC inhibitor TSA. In the mouse xenograft model, BoHV-1 effectively infected tumors and suppressed tumor growth, potentially through interaction with HDACs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiuyan Ding, Weifeng Yuan, Hao Yang, Chang Liu, Shitao Li, Liqian Zhu
Summary: The study demonstrates that BoHV-1 infection disrupts DNA damage repair mediated by 53BP1 and suggests that β-catenin plays a role in restricting both virus replication and DNA damage in A549 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Xiuyan Ding, Donna M. Neumann, Liqian Zhu
Summary: HSV-1 is a neurotropic human pathogen that can establish lifelong latency in sensory neurons and cause recurrent disease. VP16, a component of HSV-1 virion, interacts with host factors to stimulate gene transcription and affect host immune responses.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Linke Tang, Weifeng Yuan, Shitao Li, Xiuyan Ding, Liqian Zhu
Summary: In this study, the interaction between UV-primed global DDR and BoHV-1 productive infection was demonstrated. UV-primed global DDR differentially modulated the transcription of virus genes and stabilization of virus protein. Vice versa, the virus infection may affect UV-primed DDR signaling.
Article
Microbiology
Chang Liu, Jiayu Lin, Hao Yang, Ningxi Li, Linke Tang, Donna Neumann, Xiuyan Ding, Liqian Zhu
Summary: This study demonstrates that TonEBP (NFAT5) is a potential host factor that restricts bovine herpesvirus 1 (BoHV-1) infection; virus infection controls NFAT5 signaling transduction by altering NFAT5 localization and downstream target expression. Furthermore, the presence of NFAT5 in mitochondria suggests its potential involvement in regulating mitochondrial functions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Long Chang, Liqian Zhu
JOURNAL OF VETERINARY SCIENCE
(2020)