Article
Integrative & Complementary Medicine
Shanshan Li, Meng Zheng, Zhentang Zhang, Hengying Peng, Wenling Dai, Jihua Liu
Summary: This study revealed that GGEC ethyl acetate extract (EAE) significantly strengthened intestinal barrier function by increasing tight junction protein levels and reducing expression of inflammatory mediators. EAE also showed accelerated wound healing and anti-inflammatory effects.
Article
Food Science & Technology
Nguyen Thi Nu Trinh, Nguyen Ngoc Tuan, Tran Dinh Thang, Ping-Chung Kuo, Nguyen Ba Thanh, Le Nhat Tam, Le Hong Tuoi, Trang H. D. Nguyen, Danh C. Vu, Thi L. Ho, Le Ngoc Anh, Nguyen Thi Thu Thuy
Summary: This article presents the chemical composition and antioxidant activity of coffee honey from Vietnam. The study found that coffee honey samples from Vietnam are characterized by high contents of total and reducing sugars, total phenolic contents, and total flavonoid contents. The phenolic acids composition analysis revealed the presence of gallic acid and ferulic acid in high concentrations in all studied honey samples. The data highlight the relevance of coffee honey as a healthy substance.
Article
Biochemistry & Molecular Biology
Huawei Yu, Panpan Zhang, Hongbing Liu, Xiaojuan Sun, Jichao Liang, Lijuan Sun, Yong Chen
Summary: The study demonstrated the strong hypoglycemic effect of Origanum vulgare leaf extract, which inhibited alpha-glucosidase activity, promoted glucose uptake, inhibited glycosylation, and relieved oxidative stress. Mechanistic analysis showed that the extract decreased the promoter activity and the mRNA and protein expression of PEPCK and SREBP-1c, while also inhibiting the expression of CPY2E1 and enhancing the expression of GLUT2. HPLC-ESI-QTOF-MS analysis identified the main phenolic compounds in the herb, supporting its traditional use as an antidiabetic herbal medicine or dietary supplement.
Article
Microbiology
Cun Chen, Jing Cai, Ying-hong Ren, Yue Xu, Hong-ling Liu, Yu-yang Zhao, Xing-fu Chen, Zhi-bin Liu
Summary: Chinese chive extracts from different parts were tested for antimicrobial activity at different pH levels. The scape extract showed the strongest activity at pH 5.0. The major active ingredient was identified as 2-amino-5-methylbenzoic acid. The mechanism of action may involve the disruption of cell membrane integrity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Susan Christina Braga Domingos, Victor Hugo Clebis, Gerson Nakazato, Admilton Goncalves de Oliveira, Renata Katsuko Takayama Kobayashi, Rui Carlos Peruquetti, Cynthia Dias Pereira, Myrna Tielly Santa Rosa, Luciana dos Santos Medeiros
Summary: The study shows that stingless bee honey has in vitro antimicrobial activity against pathogenic bacteria. Honey from Melipona flavolineata has a damaging effect on Staphylococcus aureus cells and inhibits cell division.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Plant Sciences
Fabiana Plescia, Fabio Venturella, Marianna Lauricella, Valentina Catania, Giulia Polito, Domenico Schillaci, Antonio Palumbo Piccionello, Daidone Giuseppe, Antonella D'Anneo, Demetrio Raffa
Summary: This study aimed to determine the phytochemical composition of Artemisia arborescens extracts and evaluate their effects on cancer cells, bacteria, and biofilm formation. The extracts showed potential anticancer and antibacterial activities, as well as inhibition of biofilm formation.
Article
Biochemistry & Molecular Biology
Emil Paluch, Piotr Okinczyc, Anna Zwyrzykowska-Wodzinska, Jakub Szperlik, Barbara Zarowska, Anna Duda-Madej, Przemyslaw Babelewski, Maciej Wlodarczyk, Wioleta Wojtasik, Robert Kupczynski, Antoni Szumny
Summary: Plants from the Ilex genus are known for their antimicrobial and anti-inflammatory properties, which can be useful in medicine. Research showed that species like I. aquifolium and its cultivar have strong antibacterial activity, making them suitable for the production of antimicrobial agents, preservatives, and cosmetics.
Article
Multidisciplinary Sciences
Sarunpron Khruengsai, Teerapong Sripahco, Narawadee Rujanapun, Rawiwan Charoensup, Patcharee Pripdeevech
Summary: Essential oil extracted from Peucedanum dhana A. Ham in Thailand contained compounds such as trans-piperitol and beta-pinene. The oil exhibited significant antimicrobial activity against pathogens, and demonstrated antibacterial action against Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes. Additionally, the oil showed antioxidant activity and cytotoxicity against cancer cells, suggesting its potential application in food and pharmaceutical industries.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Guillermo Schmeda-Hirschmann, Javier Antileo-Laurie, Cristina Theoduloz, Felipe Jimenez-Aspee, Felipe Avila, Alberto Burgos-Edwards, Veronica Olate-Olave
Summary: The study found that the phenolic-enriched extracts from Araucaria araucana kernels have positive effects on antioxidant capacity, inhibitory activity on metabolic syndrome-associated enzymes, and reduction of postprandial oxidative stress. Traditional processing increases the flavan-3-ol content, indicating potential health-promoting properties of this traditional food.
Article
Biochemistry & Molecular Biology
Barbara Pacholczyk-Sienicka, Grzegorz Ciepielowski, Jakub Modranka, Tomasz Bartosik, Lukasz Albrecht
Summary: The targeted quantitative NMR (qNMR) approach is a powerful tool for classifying and determining the authenticity of honey samples. In this study, the chemical profiles of different types of Polish honey samples were determined using qNMR, and pattern recognition was performed using principal component analysis (PCA). The results showed that qNMR combined with chemometric analysis can be used as a supplementary tool for specifying honeys.
Article
Plant Sciences
Soraia I. Pedro, Tiago A. Fernandes, Angelo Luis, Alexandra M. M. Antunes, Jose C. Goncalves, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: This study evaluated the potential industrial applications of various Acacia species by examining their chemical composition, antioxidant, and antimicrobial properties. Among the studied species, A. pycnantha exhibited a higher concentration of total phenolic compounds and displayed notable antibacterial activity. Vibrational spectroscopy was a reliable method for distinguishing between species.
Article
Food Science & Technology
Evelin Kivima, Kristel Tanilas, Kaie Martverk, Sirli Rosenvald, Loreida Timberg, Katrin Laos
Summary: This study investigated 30 honey samples from different regions of Estonia to determine their chemical compositions, physicochemical properties, bioactive compounds, and sensory characteristics. Estonian honey is typically characterized by floral, berry-like, sweet, and mild sensory attributes, with a light color.
Article
Biology
Mohammad Mahfuzur Rahman, Tyeaba Tasnim Dipti, M. Nazrul Islam, Abu Tareq Mohammad Abdullah, Sharmin Jahan, Md. Morshedul Alam, M. Rezaul Karim
Summary: This study examined the suitability of Piper chaba, a traditional medicinal herb and curry spice, as a natural preservative for beef products. The results showed significant antioxidant and antibacterial activities of Piper chaba extracts. Furthermore, the study demonstrated that Piper chaba extracts could effectively preserve the quality and stability of beef products during storage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yan-Zheng Zhang, Juan-Juan Si, Shan-Shan Li, Guo-Zhi Zhang, Shuai Wang, Huo-Qing Zheng, Fu-Liang Hu
Summary: Different Chinese monofloral honeys exhibit varying antimicrobial and antioxidant activities. Some honeys show excellent antimicrobial and antioxidant properties, with a significant positive correlation between total antioxidant capacity and total phenol content. The volatile components and unique compounds present in different honey varieties can be successfully detected and analyzed using HS-GC-IMS technology.
Article
Chemistry, Medicinal
Maria Antonia Nunes, Josman Dantas Palmeira, Diana Melo, Susana Machado, Joana Correia Lobo, Anabela Silvia Guedes Costa, Rita Carneiro Alves, Helena Ferreira, Maria Beatriz Prior Pinto Oliveira
Summary: A patented process was used to extract a functional ingredient from olive pomace, which is rich in phenolic and flavonoid compounds with antioxidant properties. The ingredient, containing high levels of hydroxytyrosol, showed significant antimicrobial activity against S. aureus and E. coli, making it a potential natural preservative or nutritional enhancer.
Article
Chemistry, Applied
Francisco Javier Leyva-Jimenez, Rodrigo Oliver-Simancas, Ines Castangia, Antonio M. Rodriguez-Garcia, M. Elena Alanon
Summary: The excessive use of plastic in food packaging is a global concern, and hydrogels are emerging as a sustainable alternative. Natural hydrogels can be functionalized with bioactive compounds to improve film properties and extend the shelf-life of food products.
FOOD HYDROCOLLOIDS
(2023)
Review
Nutrition & Dietetics
Alejandro Rojas-Garcia, Alvaro Fernandez-Ochoa, Maria de la Luz Cadiz-Gurrea, David Arraez-Roman, Antonio Segura-Carretero
Summary: Neurodegenerative diseases are characterized by cell damage, impaired nervous system connections, and neuronal death, leading to the loss of essential motor and cognitive functions. Bioactive compounds, particularly phenolic compounds found in plant by-products, have shown promising neuroprotective effects and could be an optimal strategy for valorizing agricultural residues. This review summarizes the triggers of neurodegeneration, examines the role of plant extracts in neuroprotection, and discusses the potential neuroprotective effects of phenolic compounds.
Article
Biochemistry & Molecular Biology
Gokhan Zengin, Alvaro Fernandez-Ochoa, Maria de la Luz Cadiz-Gurrea, Francisco Javier Leyva-Jimenez, Antonio Segura-Carretero, Fevzi Elbasan, Evren Yildiztugay, Sumira Malik, Asaad Khalid, Ashraf N. Abdalla, Mohamad Fawzi Mahomoodally
Summary: This study investigated the phytochemical profile and biological properties of Paliurus spina-christi Mill., a medicinal plant traditionally used for various human ailments. The methanol extract exhibited the strongest antioxidant and anti-tyrosinase activities. These findings contribute to the understanding of P. spina-christi as a potential source of naturally occurring bioactive compounds with biomedical applications.
Review
Biochemistry & Molecular Biology
Carmen Duque-Soto, Alejandra Quintriqueo-Cid, Ascension Rueda-Robles, Paz Robert, Isabel Borras-Linares, Jesus Lozano-Sanchez
Summary: Given the incomplete understanding of the influence of digestion and gut microbiota on antioxidant behavior, and the limitations of in vivo studies, dynamic in vitro gastrointestinal models have been promoted for research on phenolic compounds. This systematic review assessed different models and protocols used in the study of phenolic compounds, focusing on bioaccesibility and interaction with colonic microbiota. The review identified similarities and high variability in experimental conditions, administered doses, and assays, and proposed considerations to enhance comparability in research on the digestion of phenolic compounds.
Article
Pharmacology & Pharmacy
Mohammad Firoznezhad, Rita Abi-Rached, Federica Fulgheri, Matteo Aroffu, Francisco-Javier Leyva-Jimenez, Maria de la Luz Cadiz Gurrea, Maria Cristina Meloni, Francesco Corrias, Elvira Escribano-Ferrer, Jose Esteban Peris, Maria Letizia Manca, Maria Manconi
Summary: In this study, an antioxidant phytocomplex was extracted from the flowers of E. amoenum and loaded into liposomes. The liposomes were enriched with different bioadhesive polymers individually or in combination. The physico-chemical properties of the prepared vesicles were measured, as well as their stability on storage. The biocompatibility and the ability of the formulations to protect keratinocytes and promote cell migration were evaluated in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Green & Sustainable Science & Technology
Matteo Perra, Francisco-Javier Leyva-Jimenez, Maria Letizia Manca, Maria Manconi, Hiba N. Rajha, Isabel Borras-Linares, Antonio Segura-Carretero, Jesus Lozano-Sanchez
Summary: The aim of this study was to optimize the recovery of phenolic compounds from Cannonau grape pomaces using Pressurized Liquid Extraction (PLE). Response Surface Methodology (RSM) based on a Central Composite Design 23 model was used to perform PLE experiments. The results showed that the optimum values for phenolics extraction were 130 degrees C, 55% ethanol, and 22 min. The proposed experimental model proved to be a valuable alternative method for the extraction of bioactive compounds from wine-making by-products.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Review
Food Science & Technology
Carmen Duque-Soto, Xavier Exposito-Almellon, Paula Garcia, Maria Elsa Pando, Isabel Borras-Linares, Jesus Lozano-Sanchez
Summary: Phenolic compounds have attracted research interest due to their potential health benefits, but their bioactivity may be limited by their instability or low concentration in foods. Different extraction systems have been used to obtain enriched phenolic extracts from vegetable sources. In vitro and in vivo studies have demonstrated their bioactivity, particularly in relation to obesity and related disorders. This review focuses on the extraction of phenolic compounds using experimental designs, the influence of extraction systems on the phytochemical composition, and the bioaccessibility and bioactivity of Hibiscus phenolic extracts. The results highlight the potential of Hibiscus as a source of bioactive compounds for functional food development, but further research is needed.
Review
Nutrition & Dietetics
Xavier Exposito-Almellon, Carmen Duque-Soto, Lucia Lopez-Salas, Rosa Quirantes-Pine, Cristiano Ragagnin de Menezes, Isabel Borras-Linares, Jesus Lozano-Sanchez
Summary: The waste produced by food industrial processing is an environmental problem that can be addressed by extracting nondigestible carbohydrates and other bioactive substances for microbiota modulation and health benefits.
Review
Food Science & Technology
Carmen Duque-Soto, Ana Ruiz-Vargas, Ascension Rueda-Robles, Rosa Quirantes-Pine, Isabel Borras-Linares, Jesus Lozano-Sanchez
Summary: Studies on the phenolic compounds of aromatic spices have shown their potential as food additives with bioactivity. However, research on their phenolic composition and application in food industry is limited. A systematic review revealed that these spices have a diverse phenolic profile and bioactivity, highlighting their potential as food additives, but further research is needed on their role in food matrices.
Article
Plant Sciences
Ricardo S. S. Aleman, Jhunior Marcia, Carmen Duque-Soto, Jesus Lozano-Sanchez, Ismael Montero-Fernandez, Juan A. A. Ruano, Roberta Targino Hoskin, Marvin Moncada
Summary: In this study, aqueous and ethanolic extracts of white willow bark were obtained using different extraction methods. The extracts were analyzed for their phytochemical content and biological properties. The results showed that microwave-assisted ethanolic extracts had the highest phenolic, tannin, and flavonoid contents, as well as strong antioxidant activity. The extracts also exhibited antibacterial and anti-inflammatory effects. Overall, microwave-assisted ethanolic extraction of white willow bark could be a valuable resource for multiple medicinal uses.
