Evaluating the role of Tregs in the progression of multiple myeloma

Regulatory T-cells drive immune dysfunction in CLL

(2017) Deepesh Lad et al.   LEUKEMIA & LYMPHOMA

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

(2016) J. Krejcik et al.   BLOOD

The T Cell in Myeloma

(2016) Douglas Joshua et al.   Clinical Lymphoma Myeloma & Leukemia

The tumor microenvironment shapes hallmarks of mature B-cell malignancies

(2015) K H Shain et al.   ONCOGENE

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status

(2014) M. Foglietta et al.   HAEMATOLOGICA

International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

(2014) S Vincent Rajkumar et al.   LANCET ONCOLOGY

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

(2013) A. M. Pesenacker et al.   BLOOD

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

(2013) T. Guichelaar et al.   CLINICAL CANCER RESEARCH

IMWG consensus on risk stratification in multiple myeloma

(2013) W J Chng et al.   LEUKEMIA

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state

(2013) James Favaloro et al.   LEUKEMIA & LYMPHOMA

The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma

(2012) K Giannopoulos et al.   BRITISH JOURNAL OF CANCER

Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias

(2012) Deepesh P. Lad et al.   LEUKEMIA & LYMPHOMA

Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

(2012) Sylvia Feyler et al.   PLoS One

Increased T Regulatory Cells Are Associated with Adverse Clinical Features and Predict Progression in Multiple Myeloma

(2012) Karthick Raja Muthu Raja et al.   PLoS One

Both CD4+ FoxP3+ and CD4+ FoxP3− T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro

(2011) Camilla A. Lindqvist et al.   IMMUNOLOGY

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

(2010) K. Noonan et al.   BLOOD

Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

(2010) R. H. Prabhala et al.   BLOOD

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management

(2010) R A Kyle et al.   LEUKEMIA

Significantly reduced regulatory T cell population in patients with untreated multiple myeloma

(2010) Ritu Gupta et al.   LEUKEMIA RESEARCH

CD4+CD25+FoxP3+regulatory T cells are increased whilst CD3+CD4−CD8−αβTCR+Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden

(2009) Sylvia Feyler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Effector/Memory but Not Naive Regulatory T Cells Are Responsible for the Loss of Concomitant Tumor Immunity

(2009) Yung-Chang Lin et al.   JOURNAL OF IMMUNOLOGY