Article
Chemistry, Multidisciplinary
Decai Zhao, Yanze Wei, Quan Jin, Nailiang Yang, Yang Yang, Dan Wang
Summary: The construction of pH-responsive antimicrobial carriers with hierarchical shells using polyethylene glycol as a regulator is reported in this study. These carriers exhibit rapid release of molecules and controlled diffusion of antimicrobials, resulting in long-lasting mildew resistance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Keni Yang, Karolina Tran, Anna Salvati
Summary: Ideal drug carriers should maintain stability in biological environments and release drugs once inside targeted cells. However, balancing these two aspects can be challenging. This study combined kinetic studies, aging experiments, and chromatography to determine drug release profiles in biological environments and cells, using liposomes as model nanomedicines. The results demonstrated that liposome stability and intracellular release kinetics could be controlled by changing the lipid composition.
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Polymer Science
Mengyuan Tian, Fuhua Xin, Yanjing Gao, Jun Nie, Fang Sun
Summary: The NIR-triggered photo/thermal dual-responsive composite carrier UCNPs-NG-PDA exhibits excellent photothermal conversion capability, significantly enhanced drug release under NIR irradiation, and promising application prospects in drug delivery fields.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anna A. Efimova, Anton S. Popov, Alexey V. Kazantsev, Pavel I. Semenyuk, Irina M. Le-Deygen, Nikolay V. Lukashev, Alexander A. Yaroslavov
Summary: pH-sensitive liposomes with embedded AMS showed rapid cargo release when pH was altered, but the mechanism is not yet fully understood. This article presents the details of fast cargo release based on ATR-FTIR spectroscopy and molecular modeling. The findings are relevant to the potential use of AMS-containing pH-sensitive liposomes for drug delivery.
Article
Materials Science, Biomaterials
Hongtong Lu, Shasha He, Qingfei Zhang, Xiaoyuan Li, Zhigang Xie, Zigui Wang, Yanxin Qi, Yubin Huang
Summary: This study developed dual-sensitive dual-prodrug nanoparticles (DDNPs) for photoactivated platinum-based synergistic chemotherapy, releasing demethylcantharidin to enhance the effect of platinum-based chemotherapy. DDNPs demonstrated a powerful synergistic anti-cancer effect in vitro and in vivo.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Qingshan Xiong, Qunling Fang, Kezhu Xu, Guanghui Liu, Min Sang, Yunqi Xu, Lingyun Hao, Shouhu Xuan
Summary: The study synthesized non-spherical α-Fe2O3@Au/PDA core/shell nanoparticles with tunable shapes, showing excellent photothermal sterilization effects; by controlling the thickness and composition of the Au/PDA hybrid shell, the particles demonstrate unique controllable antibacterial effects; the high performance products for photothermal antibacterial therapy have great potential for synergistic antimicrobial treatment.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Meili Shen, Shunyu Yao, Shaojing Li, Xiaodong Wu, Shun Liu, Qingbiao Yang, Jianshi Du, Jingyuan Wang, Xiangyu Zheng, Yapeng Li
Summary: The study developed a dual-response drug delivery system for the treatment of atherosclerosis, which could release drugs in response to the special microenvironment of plaques and detach under shear stress stimulus. The system showed better therapeutic effects and excellent safety in vivo compared to free drugs, demonstrating its promising potential for atherosclerosis treatment.
Review
Chemistry, Medicinal
Yupeng Fu, Ying Ding, Litao Zhang, Yongmin Zhang, Jiang Liu, Peng Yu
Summary: Polyethylene glycol (PEG) is a promising material for drug delivery due to its unique features including hydrophilicity, biocompatibility, and biodegradability；PEG molecules can protect delivery systems, reduce immunogenicity, and avoid undesirable enzymolysis；PEG has been widely applied in various delivery systems such as micelles, vesicles, nanoparticles, and hydrogels.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Chemical
Ming Liu, Chenxu Yan, Jianwei Han, Zhiqian Guo, Wei-Hong Zhu, Zuobing Xiao, Yue Wu, Jian Huang
Summary: This study successfully developed a dual-controllable profragrance platform based on pH-activated polymer, ensuring specific pH-triggered fragrance release with high stability and controllability. The activated polymers demonstrated excellent pH-switchable property and the release performance fitting to First-Order kinetic model for all three profragrances.
Article
Pharmacology & Pharmacy
Khaled S. Allemailem, Abdullah M. Alnuqaydan, Ahmad Almatroudi, Faris Alrumaihi, Aseel Aljaghwani, Habibullah Khalilullah, Hina Younus, Arif Khan, Masood A. Khan
Summary: The study demonstrated that liposomal thymoquinone may be an effective treatment for drug-sensitive or drug-resistant Acinetobacter baumannii infections. In the experiment, Lip-TQ treatment significantly increased the survival rate of mice and reduced the bacterial load in the lung tissues of infected mice.
Article
Chemistry, Multidisciplinary
Ju Hyang Park, Kyung Eun Sung, Ki Hak Kim, Jong Ryeol Kim, Jongbok Kim, Geon Dae Moon, Dong Choon Hyun
Summary: This work presents the fabrication of AuNR@MSNs with independent sensitivities to pH and NIR light for reversible drug release. The inclusion of thermosensitive and pH-sensitive gatekeepers allows controlled drug release under specific conditions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Adam Juhasz, Ditta Ungor, Norbert Varga, Gabor Katona, Gyorgy T. Balogh, Edit Csapo
Summary: The encapsulation possibilities of neuroprotective drug KYNA using lipid-based nanocarriers to increase BBB permeability were studied. Preparation conditions and characterization of liposomes were optimized. The drug-loaded liposomes showed improved BBB penetration and lipid membrane retention compared to the unformatted drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
